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Involvement of the orexin 1 and 2 receptors in nucleus incertus (NI) on modulation of spatial reference memory in the Morris water maze | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 16 آذر 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.360799.2607 | ||
| نویسندگان | ||
| Fatemeh Eslami1؛ Esmaeil Akbari* 2؛ Vahab Babapour3؛ Morteza Zendehdel3 | ||
| 1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran | ||
| 2Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran | ||
| 3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran | ||
| چکیده | ||
| The nucleus incertus (NI) is a distinct area within the brainstem near the posterior part of the tegmentum. This part of the brain consists of some heterogeneous neurons that play roles in different functions, including response to stress, arousal, learning, and modulating hippocampal theta rhythm. Orexin neuropeptides also have widespread distributions and overlapping actions within the NI. However, the actions of the orexin receptors in the NI are not well characterized. In the present study, the effect of post-training and pre-probe of trial intra-NI administration of SB-33486-A (OX1R antagonist) (12 μg/0.5μl) and TCS-OX2-29 (OX2R antagonist) (10 μg/0.5 μl) on consolidation and retrieval in Morris Water Maze (MWM) task was examined. In the experiment 1, rats were trained in MWM and immediately after every training received injections of Dimethyl sulfoxide (DMSO) (control group), SB-334867-A, and TCS-OX2-29 into NI. Experiment 2 was similar to experiment 1 except rats received DMSO, SB-33486-A, and TCS-OX2-29, 15 minutes before the probe test. In subsequent experiments, probe and visible tests were performed after the last training and distance moved, escape latency, and velocity were recorded. In experiment 3, rats trained in experiments 1 and 2 immediately after the probe test were given trials for visuomotor coordination assessment on the visible platform. The results showed that the spatial reference memory consolidation phase was significantly impaired by SB-334867-A or TCS-OX2-29 (P < 0.05), while the retrieval phase was not affected (P > 0.05). Therefore, it can be concluded that the orexinergic system in the NI has a key role in consolidation in rats through both OX1 and OX2 receptors. | ||
| کلیدواژه‌ها | ||
| Orexin receptors؛ Nucleus incertus؛ Morris water maze؛ Memory | ||
| عنوان مقاله [English] | ||
| درگیری گیرنده های ارکسینی 1 و 2 در هسته اینسرتوس بر تعدیل حافظه فضایی در موریس واتر میز | ||
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