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Eslami, Fatemeh, Akbari, Esmaeil, Babapour, Vahab, Zendehdel, Morteza. (1401). Involvement of the orexin 1 and 2 receptors in nucleus incertus (NI) on modulation of spatial reference memory in the Morris water maze. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.360799.2607
Fatemeh Eslami; Esmaeil Akbari; Vahab Babapour; Morteza Zendehdel. "Involvement of the orexin 1 and 2 receptors in nucleus incertus (NI) on modulation of spatial reference memory in the Morris water maze". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.360799.2607
Eslami, Fatemeh, Akbari, Esmaeil, Babapour, Vahab, Zendehdel, Morteza. (1401). 'Involvement of the orexin 1 and 2 receptors in nucleus incertus (NI) on modulation of spatial reference memory in the Morris water maze', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.360799.2607
Eslami, Fatemeh, Akbari, Esmaeil, Babapour, Vahab, Zendehdel, Morteza. Involvement of the orexin 1 and 2 receptors in nucleus incertus (NI) on modulation of spatial reference memory in the Morris water maze. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.360799.2607

Involvement of the orexin 1 and 2 receptors in nucleus incertus (NI) on modulation of spatial reference memory in the Morris water maze

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 16 آذر 1401
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360799.2607
نویسندگان
Fatemeh Eslami1؛ Esmaeil Akbari* 2؛ Vahab Babapour3؛ Morteza Zendehdel3
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Physiology and Pharmacology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
چکیده
The nucleus incertus (NI) is a distinct area within the brainstem near the posterior part of the tegmentum. This part of the brain consists of some heterogeneous neurons that play roles in different functions, including response to stress, arousal, learning, and modulating hippocampal theta rhythm. Orexin neuropeptides also have widespread distributions and overlapping actions within the NI. However, the actions of the orexin receptors in the NI are not well characterized. In the present study, the effect of post-training and pre-probe of trial intra-NI administration of SB-33486-A (OX1R antagonist) (12 μg/0.5μl) and TCS-OX2-29 (OX2R antagonist) (10 μg/0.5 μl) on consolidation and retrieval in Morris Water Maze (MWM) task was examined. In the experiment 1, rats were trained in MWM and immediately after every training received injections of Dimethyl sulfoxide (DMSO) (control group), SB-334867-A, and TCS-OX2-29 into NI. Experiment 2 was similar to experiment 1 except rats received DMSO, SB-33486-A, and TCS-OX2-29, 15 minutes before the probe test. In subsequent experiments, probe and visible tests were performed after the last training and distance moved, escape latency, and velocity were recorded. In experiment 3, rats trained in experiments 1 and 2 immediately after the probe test were given trials for visuomotor coordination assessment on the visible platform. The results showed that the spatial reference memory consolidation phase was significantly impaired by SB-334867-A or TCS-OX2-29 (P < 0.05), while the retrieval phase was not affected (P > 0.05). Therefore, it can be concluded that the orexinergic system in the NI has a key role in consolidation in rats through both OX1 and OX2 receptors.
کلیدواژه‌ها
Orexin receptors؛ Nucleus incertus؛ Morris water maze؛ Memory
عنوان مقاله [English]
درگیری گیرنده های ارکسینی 1 و 2 در هسته اینسرتوس بر تعدیل حافظه فضایی در موریس واتر میز
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