Sabah, Tabarak, M.H. AL-Ghaban, Nada. (1401). Evaluation of the effects of Amoxicillin on tooth development in rats by histological and histomorphometric study. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.360194.2564
Tabarak Sabah; Nada M.H. AL-Ghaban. "Evaluation of the effects of Amoxicillin on tooth development in rats by histological and histomorphometric study". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.360194.2564
Sabah, Tabarak, M.H. AL-Ghaban, Nada. (1401). 'Evaluation of the effects of Amoxicillin on tooth development in rats by histological and histomorphometric study', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.360194.2564
Sabah, Tabarak, M.H. AL-Ghaban, Nada. Evaluation of the effects of Amoxicillin on tooth development in rats by histological and histomorphometric study. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.360194.2564
Evaluation of the effects of Amoxicillin on tooth development in rats by histological and histomorphometric study
1MSc student, Oral Diagnosis Department, College of Dentistry, University of Baghdad, Iraq
2Professor, Oral Diagnosis Department, College of Dentistry, University of Baghdad, Iraq
چکیده
Amoxicillin is one of the most commonly prescribed antibiotics in children. As a result, it is prescribed as the first line of defense against cutaneous, gastrointestinal, and respiratory infections.The objectives of this study was to evaluate the effects of amoxicillin on the formation of dentin and enamel during the secretory and early phases of mineralization.Materials and methods used to perform this study was sixteen pregnant adult Wistar rats were equally divided into two groups. The first group that do not received drug and prescribed with a saline solution (control group), the other group received 250 mg/kg/day amoxicillin (study group). From the 13th gestational day until delivery, the treatment were given every day by oral gavage. After birth, the newborn rats were also received the same treatment as their mothers from first day of birth until 7or 12 day after birth. The newborns will be sacrificed at 7 and 12 days postnatally, the jaws will be dissected, and taking the maxilla,were the samples fixed in 10% formaldehyde solution and the upper first molars were analyzed histologically by H & E stain and histomorphometrically by image J to examine the enamel, dentin, ameloblast and odontoblasts mean thichness in both groups and in each healing periods.The results of study was, the mean enamel, ameloblastic layer and odontoblastic layer thickness were significantly different in the amoxicillin 250 mg/kg groups when compared to the control group. Whereas, the result revealed non significant group difference in the dentin thickness in both duration , the p value at 7 days (P = 0.147) and the p value at 12 days is (P = 0.054). Vacuolization of the ameloblastic and odontoblastic layer were observed in amoxicillin-treated groups in both duration.