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Al-Ani, F. W, Fahad, H. M. (1402). Detection of the Level of Interleukin-8 in the Serum of Burn Patients by ELISA Technique. سامانه مدیریت نشریات علمی, 78(3), 1087-1093. doi: 10.22092/ari.2022.359993.2529
F. W Al-Ani; H. M Fahad. "Detection of the Level of Interleukin-8 in the Serum of Burn Patients by ELISA Technique". سامانه مدیریت نشریات علمی, 78, 3, 1402, 1087-1093. doi: 10.22092/ari.2022.359993.2529
Al-Ani, F. W, Fahad, H. M. (1402). 'Detection of the Level of Interleukin-8 in the Serum of Burn Patients by ELISA Technique', سامانه مدیریت نشریات علمی, 78(3), pp. 1087-1093. doi: 10.22092/ari.2022.359993.2529
Al-Ani, F. W, Fahad, H. M. Detection of the Level of Interleukin-8 in the Serum of Burn Patients by ELISA Technique. سامانه مدیریت نشریات علمی, 1402; 78(3): 1087-1093. doi: 10.22092/ari.2022.359993.2529

Detection of the Level of Interleukin-8 in the Serum of Burn Patients by ELISA Technique

Archives of Razi Institute
مقاله 39، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 1087-1093    اصل مقاله (486.34 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359993.2529
نویسندگان
F. W Al-Ani* 1؛ H. M Fahad2
1Specialized Burns Hospital, Medical City, Baghdad, Iraq
2College of Medicine, AL-Iraqia University, Baghdad, Iraq
چکیده
Burn injuries are the most frequent injuries in the world, with a death rate of 2.3-3.6%. Children and people of working age constitute 85-90% of the burn cases. Burn injury results in metabolic problems, a generalized inflammatory response, inefficient energy use, and other physiological alternations that may cause organ and system dysfunction and sepsis. Sepsis is mostly caused by multiple organ failures and has unique characteristics in burn injuries, which make it the most dangerous complication of burn injuries. This study aimed to investigate the correlation between sepsis in burn patients and the level of interleukin 8 (IL-8) in their serum. In total, 60 patients with burn injuries were included in this study. Blood samples were obtained from 60 burn patients and 30 healthy individuals as controls. The BacT/Alert and Vitek2 systems were used to identify the bacteria and determine their susceptibility to these bacteria. Moreover, enzyme-linked immunosorbent assay (ELISA) was used to determine IL-8 serum levels. Based on the results, elevated levels of IL-8 were observed in the serum of burn patients, compared to healthy individuals. Concentration of IL-8 was significantly higher in patients with sepsis, compared to healthy individuals without sepsis.
کلیدواژه‌ها
Detection؛ Interleukin-8؛ Serum of Burn Patients؛ ELISA Technique
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مراجع
  1. Baserisalehi N, Emami A, Pirbonyeh N, Javanmardi F. Bacterial infection pattern in ventilated burn patients in the southwest of Iran. Int J Mol Clin Microbiol. 2021;11(1):1410-5.
  2. James SL, Lucchesi LR, Bisignano C, Castle CD, Dingels ZV, Fox JT, et al. Epidemiology of injuries from fire, heat and hot substances: global, regional and national morbidity and mortality estimates from the Global Burden of Disease 2017 study. Inj Prev. 2020;26(Suppl 2):i36-i45.
  3. Chaudhary NA, Munawar MD, Khan MT, Rehan K, Sadiq A, Tameez-ud-din A, et al. Epidemiology, Bacteriological Profile, and Antibiotic Sensitivity Pattern of Burn Wounds in the Burn Unit of a Tertiary Care Hospital. Cureus. 2019;11(6):e4794.
  4. Trzeciak A, Pietropaoli AP, Kim M. Biomarkers and Associated Immune Mechanisms for Early Detection and Therapeutic Management of Sepsis. Immune Netw. 2020;20(3):e23.
  5. Raziyeva K, Kim Y, Zharkinbekov Z, Kassymbek K, Jimi S, Saparov A. Immunology of Acute and Chronic Wound Healing. Biomolecules. 2021;11(5).
  6. Zheng M, Ambesi A, McKeown-Longo PJ. Role of TLR4 Receptor Complex in the Regulation of the Innate Immune Response by Fibronectin. Cells. 2020;9(1).
  7. Corcione S, Lupia T, De Rosa FG. Microbiome in the setting of burn patients: implications for infections and clinical outcomes. Burns Trauma. 2020;8:033.
  8. Torres MJM, Peterson JM, Wolf SE. Detection of Infection and Sepsis in Burns. Surg Infect (Larchmt). 2021;22(1):20-7.
  9. Xanthe LS, Allison JC. The Role of the Inflammatory Response in Burn Injury. In: Selda Pelin K, Dilek B, editors. Hot Topics in Burn Injuries. Rijeka: IntechOpen; 2017. p. Ch. 3.
  10. Bergquist M, Hastbacka J, Glaumann C, Freden F, Huss F, Lipcsey M. The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome. Burns. 2019;45(2):354-63.
  11. El Ayadi A, Herndon DN, Finnerty CC. Biomarkers in burn patient care. Total burn care: Elsevier; 2018. p. 232-5. e2.
  12. Jo SJ, Park KG, Han K, Park DJ, Park YJ. Direct Identification and Antimicrobial Susceptibility Testing of Bacteria From Positive Blood Culture Bottles by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and the Vitek 2 System. Ann Lab Med. 2016;36(2):117-23.
  13. Gulhan B, Kanik Yuksek S, Hayran M, Ozkaya Parlakay A, Guney D, Akin Kagizmanli G, et al. Infections in Pediatric Burn Patients: An Analysis of One Hundred Eighty-One Patients. Surg Infect (Larchmt). 2020;21(4):357-62.
  14. Abood R, M. Laboratory assessment of C-reactive protein (CRP), procalcitonin (PCT) and serum amyloid A-2 protein (SAA2) as biomarkers of pediatric bacterial blood stream infection. 2021.
  15. Devrim I, Kara A, Duzgol M, Karkiner A, Bayram N, Temir G, et al. Burn-associated bloodstream infections in pediatric burn patients: Time distribution of etiologic agents. Burns. 2017;43(1):144-8.
  16. Kraft R, Herndon DN, Finnerty CC, Cox RA, Song J, Jeschke MG. Predictive Value of IL-8 for Sepsis and Severe Infections After Burn Injury: A Clinical Study. Shock. 2015;43(3):222-7.
  17. Al-Dahhan NAA, Hussein BJ, Issa IH. Assessment of Liver Enzymes and Cytokines in Typhoid Fever. Sys Rev Pharm. 2020;11(3).
  18. Rayhaan S, Hameed RM, Hnewa RA-A. The Dynamic Alteration in Levels of Serum Amyloid a As an Indicator of Prediction Severity Of COVID-19 Infection in Iraqi Population. Rev Int Geogr Educ Online. 2021;11(12).
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