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W. Mahde, Basam, Abbas Hussein, Ahmed, S. Sahib, Ameer. (1401). Preparation and in vitro evaluation of rasagiline mesylate hybrid nanoparticles. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.360193.2563
Basam W. Mahde; Ahmed Abbas Hussein; Ameer S. Sahib. "Preparation and in vitro evaluation of rasagiline mesylate hybrid nanoparticles". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.360193.2563
W. Mahde, Basam, Abbas Hussein, Ahmed, S. Sahib, Ameer. (1401). 'Preparation and in vitro evaluation of rasagiline mesylate hybrid nanoparticles', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.360193.2563
W. Mahde, Basam, Abbas Hussein, Ahmed, S. Sahib, Ameer. Preparation and in vitro evaluation of rasagiline mesylate hybrid nanoparticles. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.360193.2563

Preparation and in vitro evaluation of rasagiline mesylate hybrid nanoparticles

Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 03 آذر 1401  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360193.2563
نویسندگان
Basam W. Mahde email 1؛ Ahmed Abbas Hussein2؛ Ameer S. Sahib3
1University of al-qadisiyah/ college of pharmacy/Iraq College of Pharmacy, University of Baghdad/Iraq
2Baghdad College of Medical Sciences/Iraq
3Al-Mustaqbal University College, Babylon, Iraq
چکیده
Rasagiline is a selective and irreversible inhibitor of MAO-B effective for the treatment of Parkinson disease (PD), and in experimental models, they had antioxidant and anti-apoptotic activity. It has low permeability and has low permeability and oral bioavailability is weak and highly variable due to extensive first-pass hepatic metabolism (35%). The aim if study is to formulate rasagilinemesylate (RM) as lipid- polymer hybrid nanoparticle in order to enhance its permeation, increase its chance to be absorbed by lymphatic circulation to avoid metabolisim and control its release. Successful formulation (PCL-2) was reached by nanoprecipitation method using in organic phase poly caprolactone with RM and lecithine in aqueous phase DSPE-PEG, lipid /polymer ratio 24% and DSPE/lecithine 50% that resulted in a stable nanoparticels having: Particle size 132±4.58 nm, Polydispersity index 0.273±0.02, zeta potential-25.6±3.3, entrapment efficiency 46±3.9% and drug loading 51.93±6.5. The result of study showed that the diffusion was more effective on the release profile than degradation and resulted in a Fickian diffusion mechanism.
کلیدواژه‌ها
Preparation؛ and in vitro evaluation؛ of rasagiline mesylate hybrid nanoparticles
آمار
تعداد مشاهده مقاله: 4


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