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| تعداد نشریات | 281 |
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Transdermal microneedle-mediated delivery of rasagiline nanoparticles | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 03 آذر 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.360192.2562 | ||
| نویسندگان | ||
Basam W. Mahde  1؛ Ahmed Abbas Hussein2؛ Khulood M. Alsaraf3؛ Hussein Abdelamir Mohammad1
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| 1University of al-qadisiyah/ college of pharmacy/Iraq | ||
| 2Baghdad College of Medical Sciences/Iraq | ||
| 3Al-Esraa University College, Iraq | ||
| چکیده | ||
| The goal of this study is to formulate rasagiline mesylate (RM) as a transdermal microneedle. RM is an antiparkinson drug, acoording to BCS it can be classified as class lll with low permeability and subjected to extensive first pass metabolism. At first it was formulated as nanoparticles by the use of chitosan (CS) polymer and ion gelation method, then the prepared nanoparticles were incorporated into transdermal microneedle (MN) that formulated by a polydimetThe transdermal drug delivery system is administered by the skin and attains a systemic effect. It is a kind of drug dosage that includes drug transport to the epidermis and potentially dermal tissue of the skin for locally therapeutic effect, while an exceptionally significant drug division is transported in systemic blood circulation. This study aimed to formulate rasagiline mesylate (RM) as a transdermal microneedle delivery. RM is an antiparkinson drug; it can be classified as class III with low permeability and subjected to extensive first-pass metabolism. At first, it was formulated as nanoparticles using the chitosan (CS) polymer and ion gelation method; then, the prepared nanoparticles were incorporated into a transdermal microneedle (MN) formulated by a polydimethylsiloxane template. The two-step casting process uses two polymer concentrations of PVA and mixes with other polymers in a 3:1 ratio (PVP and chitosan) and glycerin as a plasticizer. The selected MN formula was MN4 which had a promising shape, was free of bubbles, had fine and well-formed sharp needles passed the folding endurance test with 130 folding times before broken, had a drug content of 97±10.02%, and the Ex-Vivo Permeation. The results of this study showed a significant (p > 0.05) permeability enhancement and increase of flux (160%) compared with the transdermal patch. RS polymeric nanoparticles were successfully prepared and loaded within dissolving microneedles of sufficient mechanical strength to penetrate the stratum corneum and enhance the amount permeated through it to induce systemic effect transdermally. | ||
| کلیدواژه‌ها | ||
| Transdermal؛ Microneedle - Mediated؛ Delivery of Rasagiline Nanoparticles | ||
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آمار تعداد مشاهده مقاله: 4 |
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