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Auni Kamal, D, Fisal Shakir Agha, N, Housein, Z. (1402). Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma. سامانه مدیریت نشریات علمی, 78(3), 989-995. doi: 10.22092/ari.2022.360240.2567
D Auni Kamal; N Fisal Shakir Agha; Z Housein. "Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma". سامانه مدیریت نشریات علمی, 78, 3, 1402, 989-995. doi: 10.22092/ari.2022.360240.2567
Auni Kamal, D, Fisal Shakir Agha, N, Housein, Z. (1402). 'Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma', سامانه مدیریت نشریات علمی, 78(3), pp. 989-995. doi: 10.22092/ari.2022.360240.2567
Auni Kamal, D, Fisal Shakir Agha, N, Housein, Z. Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma. سامانه مدیریت نشریات علمی, 1402; 78(3): 989-995. doi: 10.22092/ari.2022.360240.2567

Upregulation of XRCC1 DNA Repair Gene, Interleukin-8, and Bcl-2 Antiapoptotic Gene Levels in Kurdish Patients with Gastric Adenocarcinoma

Archives of Razi Institute
مقاله 26، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 989-995    اصل مقاله (523.5 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360240.2567
نویسندگان
D Auni Kamal1؛ N Fisal Shakir Agha2؛ Z Housein* 1
1Department of Medical Laboratory Technology, Erbil Health and Medical Technical College, Erbil Polytechnic University, Erbil 44001, Kurdistan Region, Iraq
2Department of Anesthesia, Erbil Medical Technical Institute, Erbil Polytechnic University, Erbil 44001, Kurdistan Region, Iraq
چکیده
Gastric cancer (GC) is one of the deadliest tumors due to its competence to invade and metastasize. The DNA repair gene (XRCC1), interleukin-8 (IL-8) gene, and B-cell lymphoma 2 (Bcl-2) gene play a crucial role in the development and progression of GC. This study aimed to evaluate the expression of these target genes in GC patients in the Kurdistan region of Iraq. Gastric cancer tissues were collected from 29 patients diagnosed with gastric adenocarcinoma that underwent gastric resection, and 21 tissue samples were obtained from healthy patients that underwent gastroscopy. The gastric tissues were collected in different hospitals in Erbil and Sulaymaniyah cities in the Kurdistan region of Iraq. Moreover, the data regarding Helicobacter pylori, age, gender, and stage of the disease were recorded and analyzed using GraphPad Prism. The gene expression levels of XRCC1, IL-8, and Bcl-2 from gastric tissue were studied by real-time quantitative polymerase chain reaction. The results showed that H. pylori infection was equally distributed among males and females in the tissues of gastric patients, while most of the H. pylori-negative patients were females. It is also found that gastric patients aged 30-60 years old are more commonly tested for the H. pylori test. Accordingly, in this study, patients diagnosed with gastric inflammation more often tested positive for H. pylori, while patients diagnosed with gastric cancer tested negative for this infection. Additionally, it was found that the target genes (XRCC1, IL-8, and Bcl-2) were significantly upregulated in GC patients, compared to the healthy group. Finally, the result revealed that XRCC1, IL-8, and Bcl-2 were upregulated in the Kurdish patients with GC, compared to the healthy control group. Targeting XRCC1, IL-8, and Bcl-2 genes can be an interesting field and promising strategy for cancer treatment.
کلیدواژه‌ها
Gastric cancer؛ XRCC1؛ IL-8؛ Bcl-2؛ Gene expression
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