Evaluation of the coenzyme Q10 and some biochemical parameters in patients with ischemic heart disease

M. Ayob Alsaiegh, Othman; Lateef Husein, Ammar; Harith Mohammad, Mohammad; Dhafer Abdulnafa, Zaid

doi:10.22092/ari.2022.359889.2500

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	Evaluation of the coenzyme Q10 and some biochemical parameters in patients with ischemic heart disease
Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 مهر 1401
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359889.2500
نویسندگان
Othman M. Ayob Alsaiegh ¹؛ Ammar Lateef Husein¹؛ Mohammad Harith Mohammad²؛ Zaid dhafer abdulnafa²
¹Department of Biochemistry, College of Medicine University of Tikrit, Tikrit, Iraq;
²College of medicine, university of Mosul, Iraq
چکیده
Ischemic heart disease is a common diagnosis and a leading cause of death in both men and women. It accounts for 30% of deaths worldwide, including 40% in high-income countries and approximately 28% in developing nations. Several cardiac markers have been used to diagnose and manage cardiovascular diseases. The Coenzyme Q10 has a potential role in preventing and treating cardiovascular diseases by improving cellular bioenergetics. The aim of the study was to evaluate the role of coenzyme Q10 and other biochemical parameters in ischemic heart disease (angina pectoris and myocardial infarction). A case-control study was conducted at the Intensive Care Unit of Ibn-Sina Teaching Hospital and Al-Salam General Hospital in Nineveh Province, Iraq, for two months, from 1st April to 1st June 2022. It included 90 adult participants divided into two groups: Case group included 60 patients admitted to the Intensive Care Unit and diagnosed with ischemic heart diseases (Myocardial infarction or angina pectoris), and the control group included 30 healthy participants matched in age and gender with the case group. Subsequent assay of CRP, CPK, troponin level, and serum coenzyme Q10. In this study, 81.7% of patients in the case group were diagnosed with myocardial infarction. Means of S. LDH, CRP, CPK, and troponin were significantly higher, while means of coenzyme Q10 were significantly lower in the case group than in the controls. Statistically, a significant moderate negative correlation was detected between coenzyme Q10 level and age; significant weak correlations were seen between coenzyme Q10 level and all of S. LDH, CRP, and troponin levels. Patients with ischemic heart diseases had considerably low serum levels of coenzyme Q10 compared with the control group. The highest mean of lipid profile except TG in patients with IHD compared with the control group explains the role of cholesterol compounds in the progression of IHD. No significant correlations between coenzyme Q10 with BMI and CPK. Negative correlation between coenzyme Q10 with age, s. LDH, CRP, and troponin.
کلیدواژه‌ها
Coenzyme Q10؛ cardiovascular diseases؛ biomarkers؛ ischemia؛ Iraq

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Evaluation of the coenzyme Q10 and some biochemical parameters in patients with ischemic heart disease