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Khosravi-Nezhad, Sh, Hassanpour, Sh, Hesaraki, S. (1401). L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice. سامانه مدیریت نشریات علمی, 78(1), 195-203. doi: 10.22092/ari.2022.360066.2544
Sh Khosravi-Nezhad; Sh Hassanpour; S Hesaraki. "L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice". سامانه مدیریت نشریات علمی, 78, 1, 1401, 195-203. doi: 10.22092/ari.2022.360066.2544
Khosravi-Nezhad, Sh, Hassanpour, Sh, Hesaraki, S. (1401). 'L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice', سامانه مدیریت نشریات علمی, 78(1), pp. 195-203. doi: 10.22092/ari.2022.360066.2544
Khosravi-Nezhad, Sh, Hassanpour, Sh, Hesaraki, S. L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice. سامانه مدیریت نشریات علمی, 1401; 78(1): 195-203. doi: 10.22092/ari.2022.360066.2544

L-Theanine Improves Locomotor Function in a Model of Multiple Sclerosis Mice

Archives of Razi Institute
مقاله 26، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 195-203    اصل مقاله (759.54 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.360066.2544
نویسندگان
Sh Khosravi-Nezhad1؛ Sh Hassanpour* 2؛ S Hesaraki1
1Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
This study designed to investigate the protective effects of L-theanine on experimental Multiple sclerosis in mice. Frothy Male C57BL/6 mice were allocated into 4 experimental groups: control no treatment received a regular chew pellet, and the cuprizone (CPZ) group received a standard chew pellet containing 0.2% (w/w) CPZ. In group 3, mice were fed a regular diet and administered p.o. with L-theanine (50 mg/kg). In group 4, mice received a diet containing CPZ and were administered p.o. with L-theanine (50mg/kg). Finally, reflexive motor behavior and serum antioxidant levels were determined. Based on findings, CPZ significantly decreased ambulation score, hind-limb suspension, front limb suspension, and grip strength (P<0.05). The CPZ+L-theanine reduced the adverse effect of the CPZ on ambulation score, hind-limb foot angle, surface righting, and negative geotaxis (P<0.05). The CPZ+L-theanine increased front and hind-limb suspension, grip strength, number of the cross, and duration of a stay on the rotarod compared to the control animal (P<0.05). CPZ administration significantly elevated serum malondialdehyde (MDA) while superoxide dismutase (SOD) and glutathione peroxidase (GPx) and total antioxidant status (TAS) levels decreased compared to control mice (P<0.05). The CPZ+L-theanine leads to the cessation of MDA production while increasing SOD, GPx, and TAS levels (P<0.05). These results suggested L-theanine has a protective effect against CPZ-induced MS in mice.
کلیدواژه‌ها
Antioxidant؛ L-theanine؛ Multiple sclerosis؛ Mice
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مراجع
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