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Dahash, S. A, Kusrat Hussein, L. (1402). Interleukin-1β rs1143634 Polymorphism and Susceptibility to Periodontitis in the Iraqi Population. سامانه مدیریت نشریات علمی, 78(2), 751-756. doi: 10.22092/ari.2022.359864.2491
S. A Dahash; L Kusrat Hussein. "Interleukin-1β rs1143634 Polymorphism and Susceptibility to Periodontitis in the Iraqi Population". سامانه مدیریت نشریات علمی, 78, 2, 1402, 751-756. doi: 10.22092/ari.2022.359864.2491
Dahash, S. A, Kusrat Hussein, L. (1402). 'Interleukin-1β rs1143634 Polymorphism and Susceptibility to Periodontitis in the Iraqi Population', سامانه مدیریت نشریات علمی, 78(2), pp. 751-756. doi: 10.22092/ari.2022.359864.2491
Dahash, S. A, Kusrat Hussein, L. Interleukin-1β rs1143634 Polymorphism and Susceptibility to Periodontitis in the Iraqi Population. سامانه مدیریت نشریات علمی, 1402; 78(2): 751-756. doi: 10.22092/ari.2022.359864.2491

Interleukin-1β rs1143634 Polymorphism and Susceptibility to Periodontitis in the Iraqi Population

Archives of Razi Institute
مقاله 32، دوره 78، شماره 2، خرداد و تیر 2023، صفحه 751-756    اصل مقاله (517.3 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359864.2491
نویسندگان
S. A Dahash* 1؛ L Kusrat Hussein2
1Department of Periodontics, College of Dentistry, University of Tikrit, Tikrit, Iraq
2Department of Periodontics, College of Dentistry, University of Anbar, Anbar, Iraq
چکیده
Periodontitis is a complex multifactorial inflammatory disease, and its genetic basis has been studied. The Interleukin-1 beta (IL-1β) is a crucial proinflammatory mediator in the pathogenesis of periodontitis with high polymorphism. This study aimed to investigate whether the rs1143634 genetic variant of the IL-1β gene is associated with an increased risk for periodontitis. For this purpose, genotyping of the IL-1β rs1143634 polymorphism was performed using the polymerase chain reaction-restriction fragment length polymorphism method on 90 patients within the age range of 35-60 years old. They were divided into two groups: 64 periodontitis cases (stage 3 and 4 periodontitis according to 2017 classification) and 26 racially matched healthy cases as the control group. Fisher's exact test showed a significant decrease in TT homozygous genotype in periodontitis cases, compared to the control group (P=0.018), suggesting that this genotype is a protective factor in the test population. Allele frequency showed an elevated odd ratio (1.24) and increased risk for periodontitis in subjects with allele C and reduced odd ratio (0.81) and reduced risk for periodontitis in subjects with allele T. Allele T of IL-1β rs1143634 polymorphism could be a protective factor, while Allele C of this polymorphism could be a risk factor for periodontitis in the studied Iraqi population.
کلیدواژه‌ها
Association؛ Interleukin-1β rs1143634 polymorphism؛ Periodontitis
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مراجع
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