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Tuama, M. Q, Ibrahim, W. N, Sharief, M. (1402). Correlation of Estrogen Receptor Alpha Serum Level with Gene Polymorphism and Its Effect on Women with Unexplained Infertility, Basra, Iraq. سامانه مدیریت نشریات علمی, 78(2), 775-783. doi: 10.22092/ari.2022.359863.2490
M. Q Tuama; W. N Ibrahim; M Sharief. "Correlation of Estrogen Receptor Alpha Serum Level with Gene Polymorphism and Its Effect on Women with Unexplained Infertility, Basra, Iraq". سامانه مدیریت نشریات علمی, 78, 2, 1402, 775-783. doi: 10.22092/ari.2022.359863.2490
Tuama, M. Q, Ibrahim, W. N, Sharief, M. (1402). 'Correlation of Estrogen Receptor Alpha Serum Level with Gene Polymorphism and Its Effect on Women with Unexplained Infertility, Basra, Iraq', سامانه مدیریت نشریات علمی, 78(2), pp. 775-783. doi: 10.22092/ari.2022.359863.2490
Tuama, M. Q, Ibrahim, W. N, Sharief, M. Correlation of Estrogen Receptor Alpha Serum Level with Gene Polymorphism and Its Effect on Women with Unexplained Infertility, Basra, Iraq. سامانه مدیریت نشریات علمی, 1402; 78(2): 775-783. doi: 10.22092/ari.2022.359863.2490

Correlation of Estrogen Receptor Alpha Serum Level with Gene Polymorphism and Its Effect on Women with Unexplained Infertility, Basra, Iraq

Archives of Razi Institute
مقاله 35، دوره 78، شماره 2، خرداد و تیر 2023، صفحه 775-783    اصل مقاله (916.86 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359863.2490
نویسندگان
M. Q Tuama* ؛ W. N Ibrahim؛ M Sharief
Department of Microbiology, College of Medicine, University of Basrah, Basrah, Iraq
چکیده
Infertility of unknown etiology is considered a significant medical and health problem. This study focused on the role of the estrogen receptor alpha (ESRα) gene polymorphism, PvuII (rs2234693), and its effect on the amount of ESRα in the blood of women who cannot get pregnant for unknown reasons. A total of 184 females were evaluated, including 102 with unexplained infertility (UI) and 82 age-matched control females (with at least one living child and no history of infertility). Blood samples were collected, genomic DNA was isolated from blood samples, and the genotyping of the ESRα gene was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). ESRα expression levels were assessed by the ELISA. The study revealed that the mean serum level of ESRα was significantly higher in the case group than in the control group (P<0.05). Furthermore, the genotypes (TT, TC, and CC) and alleles (T and C) significantly influenced the plasma level of ESRα in the study population. Moreover, the presence of the C allele was considered a risk factor, and the polymorphism had a significant effect on ESRα expression level in women with UI.
کلیدواژه‌ها
Estrogen receptor alpha؛ Female infertility؛ Gene polymorphism؛ Genotyping؛ RFLP
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مراجع
  1. Cakmak H, Taylor HS. Implantation failure: molecular mechanisms and clinical treatment. Hum Reprod Update. 2011;17(2):242-53.
  2. Haouzi D, Mahmoud K, Fourar M, Bendhaou K, Dechaud H, De Vos J, et al. Identification of new biomarkers of human endometrial receptivity in the natural cycle. Hum Reprod. 2009;24(1):198-205.
  3. Simon C, Dominguez F, Valbuena D, Pellicer A. The role of estrogen in uterine receptivity and blastocyst implantation. Trends Endocrinol Metab. 2003;14(5):197-9.
  4. Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, et al. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology. 2006;147(3):1097-121.
  5. Vermeirsch H, Van den Broeck W, Simoens P. Immunolocalization of sex steroid hormone receptors in canine vaginal and vulvar tissue and their relation to sex steroid hormone concentrations. Reprod Fertil Dev. 2002;14(3-4):251-8.
  6. Dorostghoal M, Ghaffari HO, Marmazi F, Keikhah N. Overexpression of Endometrial Estrogen Receptor-Alpha in The Window of Implantation in Women with Unexplained Infertility. Int J Fertil Steril. 2018;12(1):37-42.
  7. Liaqat S, Hasnain S, Muzammil S, Hayat S. Polymorphism analysisinestrogenreceptorsalphaandbetagenesandtheirassociationwithinfertilepopulation in Pakistan. EXCLI J. 2015;14:1085-94.
  8. Hsieh Y-Y, Wang Y-K, Chang C-C, Lin C-S. Estrogen receptor α-351 Xba I* G and-397 Pvu II* C-related genotypes and alleles are associated with higher susceptibilities of endometriosis and leiomyoma. Mol Hum Reprod. 2007;13(2):117-22.
  9. Olegovich Bokov D, Jalil AT, Alsultany FH, Mahmoud MZ, Suksatan W, Chupradit S, et al. Ir-decorated gallium nitride nanotubes as a chemical sensor for recognition of mesalamine drug: a DFT study. Mol Simul. 2022;48(5):438-47.
  10. Zadeh FA, Bokov DO, Salahdin OD, Abdelbasset WK, Jawad MA, Kadhim MM, et al. Cytotoxicity evaluation of environmentally friendly synthesis Copper/Zinc bimetallic nanoparticles on MCF-7 cancer cells. Rend Lincei Sci Fis Nat. 2022;33(2):441-7.
  1. Qasim M, Fenjan M, Thijail H. Molecular Identification of Cystoisospora Belli in Patients Infected With The Virus Human Immunodeficiency. Int J Drug Deliv Technol. 2022;12(2):701-4.
  2. Qasim M, Mahdi Mohammed Alakkam E, Mahdi Mohammed M, Hachim, S. ,, Sabah Jabr H, Emad Izzat S, Mohammed K, et al. Ovine Pasteurellosis Vaccine: Assessment of the Protective Antibody Titer and Recognition of the Prevailing Serotypes. Arch Razi Inst. 2022;77(3):1207-10.
  3. Tang ZR, Zhang R, Lian ZX, Deng SL, Yu K. Estrogen-Receptor Expression and Function in Female Reproductive Disease. Cells. 2019;8(10).
  4. Abdelazim IA, Purohit P, Farag RH, Zhurabekova G. Unexplained infertility: prevalence, possible causes and treatment options. A review of the literature. J Obstet Gynaecol Investigat. 2018;1(1):17-22.
  5. Swaminathan M, Ganesh V, Koshy T, Venugopal P, Paul S, Venkatesan V. A Study on the Role of Estrogen Receptor Gene Polymorphisms in Female Infertility. Genet Test Mol Biomark. 2016;20(11):692-5.
  1. Kukuvitis A, Georgiou I, Bouba I, Tsirka A, Giannouli CH, Yapijakis C, et al. Association of oestrogen receptor alpha polymorphisms and androgen receptor CAG trinucleotide repeats with male infertility: a study in 109 Greek infertile men. Int J Androl. 2002;25(3):149-52.
  2. Khulood Abdulrazaq K, Wijdan Nazar I, Qussay Nfawa Thaqab  A. INF-γ Plasma Level and Polymorphism Significance in Autastic Spectrum Disorder, A Controlled Study in Basrah. J Biotechnol Bioinform Res. 2020;2(3):1-5.
  3. Ba ZA, AL-Moosawi WN, Ali SK. Vascular Endothelial Growth Factor-A Plasma Level and-460 VEGF Gene Single Nucleotide Polymorphism Significance in Childhood Acute Lymphoblastic Leukemia in Basrah, Iraq. Eur J Mol Clin Med. 2020;8(2):1212-20.
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