Estimation of interleukin 32 and interleukin 37 serum levels in Iraqi patients with Rheumatoid arthritis

Mohammed Jasim, Esraa; Khudhur Jameel, Sanaa; Ihsan Awadh, Nabaa

doi:10.22092/ari.2022.359861.2489

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	Estimation of interleukin 32 and interleukin 37 serum levels in Iraqi patients with Rheumatoid arthritis
Archives of Razi Institute
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 شهریور 1401
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359861.2489
نویسندگان
Esraa Mohammed Jasim ¹؛ Sanaa Khudhur Jameel²؛ Nabaa Ihsan Awadh³
¹Esraa Mohammed Jasim. Al-Iraqia university /Medical College/Medical Microbiology Department. esraa.m.jasim@students.aliraqia.edu.iq
²Assistant professor Dr Sanaa Khudhur Jameel. Al-Iraqia university /Medical College/Medical Microbiology Department. dr.sanaa.khudhur@gmail.com
³Senior rheumatologist Nabaa Ihsan Awadh. Rheumatology Unit/Internal Medicine Department/ Baghdad Teaching Hospital/Medical City Complex. dr.nabaaihsan@yahoo.com
چکیده
Rheumatoid arthritis (RA) is an autoimmune condition characterized by persistent inflammation in the synovial joints. In Rheumatoid Arthritis, Interleukine-32 (IL32) is known to have significant pro-inflammatory effects, and IL37 is an anti-inflammatory cytokine that reduces immune response and inflammation. This study aimed to investigate the interleukin (IL) - 32 and IL-73 levels of serum in patients with rheumatoid arthritis (RA). The samples included 50 (46 females and four males) patients with RA and 40 healthy controls. ELISA detected serum IL-32 and IL37 levels. CDAI measured the disease parameters' activity, and ESR was measured by the Westergren method. CRP, RF, and ACPA were measured by using ELISA. The results showed elevated serum IL-32 and IL 37 levels in patients with RA (p<0.05). The mean duration of rheumatoid arthritis in most patients was < 12 years. The level of disease activity among the cases group was mainly moderate (70%). The means of interleukin-32 and interleukin-37 in patients with rheumatoid arthritis had No significant differences. This study showed that given that IL32 and IL37 play an essential role in RA pathogenesis, there was no correlation between serum levels of IL32 and IL37 with disease duration or activity.
کلیدواژه‌ها
Rheumatoid arthritis؛ IL32؛ IL37؛ Cytokines

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Estimation of interleukin 32 and interleukin 37 serum levels in Iraqi patients with Rheumatoid arthritis