اخبار و اعلانات

 آمار

تعداد نشریات283
تعداد نشریات سازمان81
تعداد شماره‌ها2,722
تعداد مقالات31,009
تعداد مشاهده مقاله27,165,126
تعداد دریافت فایل اصل مقاله16,166,010
Ali Hasan, S, Al-Rikaby, A. A. (1402). Evaluating the Influence of Rosemary Leaves Extract on Hormonal and Histopathological Alterations in Male Rabbits Exposed to Cypermethrin. سامانه مدیریت نشریات علمی, 78(3), 797-805. doi: 10.22092/ari.2022.359859.2487
S Ali Hasan; A. A Al-Rikaby. "Evaluating the Influence of Rosemary Leaves Extract on Hormonal and Histopathological Alterations in Male Rabbits Exposed to Cypermethrin". سامانه مدیریت نشریات علمی, 78, 3, 1402, 797-805. doi: 10.22092/ari.2022.359859.2487
Ali Hasan, S, Al-Rikaby, A. A. (1402). 'Evaluating the Influence of Rosemary Leaves Extract on Hormonal and Histopathological Alterations in Male Rabbits Exposed to Cypermethrin', سامانه مدیریت نشریات علمی, 78(3), pp. 797-805. doi: 10.22092/ari.2022.359859.2487
Ali Hasan, S, Al-Rikaby, A. A. Evaluating the Influence of Rosemary Leaves Extract on Hormonal and Histopathological Alterations in Male Rabbits Exposed to Cypermethrin. سامانه مدیریت نشریات علمی, 1402; 78(3): 797-805. doi: 10.22092/ari.2022.359859.2487

Evaluating the Influence of Rosemary Leaves Extract on Hormonal and Histopathological Alterations in Male Rabbits Exposed to Cypermethrin

Archives of Razi Institute
مقاله 4، دوره 78، شماره 3، مرداد و شهریور 2023، صفحه 797-805    اصل مقاله (931.03 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359859.2487
نویسندگان
S Ali Hasan؛ A. A Al-Rikaby
Department of Physiology, Pharmacology and Biochemistry, College of Veterinary Medicine, University of Basrah, Basrah, Iraq
چکیده
Rosemary Leaves (Rosmarinus officinalis) gained importance as natural antioxidants which strengthen the endogenous antioxidant defenses through die. The present experience was designed to assess the protective effect of ethanolic extract of rosemary leaves on the adrenal gland and testicular toxicity in male rabbits exposed to Cypermethrin. Forty healthy male rabbits were distributed into four groups of 10 animals each; the animals were administered cypermethrin 66.5 mg/kg alone or concurrent with Rosemary extract in both dosages (100 and 200 mg/kg) for 45 days, and the blood samples were taken from all animals for estimation hormones indices, the Anaesthetized animals were euthanized and adrenal gland and testes were separated for histopathological analysis. Results revealed that the exposure to Cypermethrin induced stress and infertility as evidenced by elevation in the level of cortisol concurrently with a lowering in ACTH level. Also, recording elevation in FSH and LH levels and a significant decline in estradiol level related to a reduction in testosterone levels observed noticeable compared to healthy control. While Concurrent exposure to Cypermethrin and Rosemary extract significantly improved hormone criteria compared to rabbits exposed to Cypermethrin alone. Histological lesions in this study include: the adrenal gland appeared thick fibrous capsule surrounding the adrenal tissue, destruction of adrenal cortex and vacuolation of three layers of the cortex, while in testes marked inhibition of spermatogenesis and degeneration of Sertoli cells with few numbers of Leydig cells were shown. These alterations were brought about by cypermethrin toxicity, while the treatment of Rosemary leaves extract with Cypermethrin alleviated the deleterious effect of Cypermethrin on the adrenal gland and testes and also restored spermatogenesis. The results showed that the extract of rosemary leaves possesses anti-infertility and strong antioxidant activities and can be used as a fertility-increasing drug to control sexual hormones also spermatogenesis, preventing toxicity and its pathophysiological consequences.
کلیدواژه‌ها
Rosemary leaves؛ ACTH؛ Cortisol؛ testosterone؛ E2؛ Adrenal gland
سایر فایل های مرتبط با مقاله
مراجع
  1. Ye X, Liu J. Effects of pyrethroid insecticides on hypothalamic-pituitary-gonadal axis: a reproductive health perspective. Environ Pollut. 2019;245:590-9.
  2. Patrick SM, Bornman MS, Joubert AM, Pitts N, Naidoo V, De Jager C. Effects of environmental endocrine disruptors, including insecticides used for malaria vector control on reproductive parameters of male rats. Reprod Toxicol. 2016;61:19-27.
  3. Mostafa HES, Abd El‐Baset SA, Kattaia AA, Zidan RA, Al Sadek MM. Efficacy of naringenin against permethrin‐induced testicular toxicity in rats. Int J Exp Pathol. 2016;97(1):37-49.
  4. Sharma P, Khan IA, Singh R. Curcumin and quercetin ameliorated cypermethrin and deltamethrin-induced reproductive system impairment in male wistar rats by upregulating the activity of pituitary-gonadal hormones and steroidogenic enzymes. Int J Fertil Steril. 2018;12(1):72.
  5. Alaa-Eldin EA, El-Shafei DA, Abouhashem NS. Individual and combined effect of chlorpyrifos and cypermethrin on reproductive system of adult male albino rats. Environ Sci Pollut Res. 2017;24(2):1532-43.
  6. Mwaheb MA, Sayed O, Mohamed S. Protective effect of rosemary (Rosmarinus officinalis) extract on Lithium induced renal and testis toxicity in albino rats. J Drug Metab Toxicol. 2016;7(216):2.
  7. Kamal A, Gabr S, Taha M. Prophylactic effect of Rosemary extract on hormonal disturbances in male Albino rats. Isot Radiat Res. 2010;42.
  8. El-sherif NM, Issa NM. Protective effect of rosemary (Rosmarinus officinalis) extract on naphthalene induced nephrotoxicity in adult male albino rat. J Interdiscip Histopathol. 2015;3(1):24-32.
  9. Lo AH, Liang YC, Lin-Shiau SY, Ho CT, Lin JK. Carnosol antioxidant in Rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-KB in mouse macrophages. Carcinogenesis. 2002;23(6):983-91.
  10. Sakr SA, Lamfon HA. Protective effect of rosemary (Rosmarinus officinalis) leaves extract on carbon tetrachloride-induced nephrotoxicity in albino rats. Life Sci J. 2012;9(1):779-85.
  11. Akela M, El Atrash A, El Kilany M, Tousson E. Qualitative and quantitative characterization of biologically active compounds of Rosemary (Rosmarinus officinalis) Leaf Extract. Journal of Advanced Trends in Basic and Appl Sci. 2018;2(1):59-64.
  12. Abbasi Oshaghi E, Khodadadi I, Saidijam M, Yadegarazari R, Shabab N, Tavilani H, et al. Lipid lowering effects of hydroalcoholic extract of Anethum graveolens L. and dill tablet in high cholesterol fed hamsters. Cholesterol. 2015;2015.
  13. Sharma P, Huq AU, Singh R. Cypermethrin induced reproductive toxicity in male Wistar rats: Protective role of Tribulus terrestris. J Environ Biol. 2013;34(5):857.
  14. Hontela A. Adrenal toxicology: environmental pollutants and the HPI axis. Biochemistry and molecular biology of fishes. 6: Elsevier; 2005. p. 331-63.
  15. Raff H, Findling J. A new immunoradiometric assay for corticotropin evaluated in normal subjects and patients with Cushing's syndrome. Clin Chem. 1989;35(4):596-600.
  16. Zhang J, Zhang J, Liu R, Gan J, Liu J, Liu W. Endocrine-disrupting effects of pesticides through interference with human glucocorticoid receptor. Environ Sci Technol. 2016;50(1):435-43.
  17. Jin Y, Wang L, Ruan M, Liu J, Yang Y, Zhou C, et al. Cypermethrin exposure during puberty induces oxidative stress and endocrine disruption in male mice. Chemosphere. 2011;84(1):124-30.
  18. Ji C, Song Q, Chen Y, Zhou Z, Wang P, Liu J, et al. The potential endocrine disruption of pesticide transformation products (TPs): The blind spot of pesticide risk assessment. Environ Int. 2020;137:105490.
  19. Marentette JR, Tong S, Balshine S. The cortisol stress response in male round goby (Neogobius melanostomus): effects of living in polluted environments? Environ Biol Fishes. 2013;96(6):723-33.
  20. Kim K-H, Kabir E, Jahan SA. Exposure to pesticides and the associated human health effects. Sci Total Environ. 2017;575:525-35.
  21. Khan IT, Nadeem M, Imran M, Ullah R, Ajmal M, Jaspal MH. Antioxidant properties of Milk and dairy products: A comprehensive review of the current knowledge. Lipids Health Dis. 2019;18(1):1-13.
  22. Labban L, Mustafa UE-S, Ibrahim YM. The effects of rosemary (Rosmarinus officinalis) leaves powder on glucose level, lipid profile and lipid perodoxation. Int J Clin Med. 2014;2014.
  23. Mostafalou S, Abdollahi M. Pesticides: an update of human exposure and toxicity. Arch Toxicol. 2017;91(2):549-99.
  24. Solati J, Hajikhani R, Toodeh Zaeim R. Effects of cypermethrin on sexual behaviour and plasma concentrations of pituitary-gonadal hormones. Int J Fertil Steril. 2010;4(1):23-8.
  25. Ye X, Li F, Zhang J, Ma H, Ji D, Huang X, et al. Pyrethroid insecticide cypermethrin accelerates pubertal onset in male mice via disrupting hypothalamic–pituitary–gonadal axis. Environ Sci Technol. 2017;51(17):10212-21.
  26. Brander SM, Gabler MK, Fowler NL, Connon RE, Schlenk D. Pyrethroid pesticides as endocrine disruptors: molecular mechanisms in vertebrates with a focus on fishes. Environ Sci Technol. 2016;50(17):8977-92.
  27. Santos R, Piccoli C, Cremonese C, Freire C. Thyroid and reproductive hormones in relation to pesticide use in an agricultural population in Southern Brazil. Environ Res. 2019;173:221-31.
  1. Modaresi M, Emadi M. The effects of rosemary extract on spermatogenesis and sexual hormones of mice under heat stress. Trends J Sci Res. 2018;3(2):69-74.
  2. Hamza FZ, Al-Sharafi NM, Kasim SF. Effect of aqueous rosemary extract on some sexual hormones in male rats with high thyroxine level. Iraqi J Vet Sci. 2021;35(2):369-73.
  3. Ghassabian A, Trasande L. Disruption in thyroid signaling pathway: a mechanism for the effect of endocrine-disrupting chemicals on child neurodevelopment. Front Endocrinol. 2018;9:204.
  4. Settar A, Oularbi K, Tarzaali D, Mekhaldi F. Ameliorative effect of vitamins a, e, d & c on ampligo a synthetic insecticide inducing toxicity on rabbit adrenal gland.
  5. Abass MA, Elkhateeb SA, Abd EL-Baset SA, Kattaia AA, Mohamed EM, Atteia HH. Lycopene ameliorates atrazine-induced oxidative damage in adrenal cortex of male rats by activation of the Nrf2/HO-1 pathway. Environ Sci Pollut Res. 2016;23(15):15262-74.
  6. Babazadeh M, Najafi G. Effect of chlorpyrifos on sperm characteristics and testicular tissue changes in adult male rats. Vet Res Forum. 2017;8(4):319.
  7. Ngoula F, Watcho P, Kenfack A, Manga JNz, Defang HF, Pierre K, et al. Effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of adult male rat. Am J Pharmacol Toxicol. 2014;9(1):75.
  8. Habtemariam S. The therapeutic potential of rosemary (Rosmarinus officinalis) diterpenes for Alzheimer’s disease. Evid-Based Complement Altern Med. 2016;2016.
  9. Ghozlan SA, El-Far A, Sadek KM, Abourawash AA, Abdel-Latif MA. Effect of rosemary (Rosmarinus officinalis) dietary supplementation in broiler chickens concerning immunity, antioxidant status, and performance. Alex J Vet Sci. 2017;55(1):152-61.
آمار
تعداد مشاهده مقاله: 1,294
تعداد دریافت فایل اصل مقاله: 418


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب