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آمار
| تعداد نشریات | 281 |
| تعداد نشریات سازمان | 80 |
| تعداد شماره‌ها | 2,395 |
| تعداد مقالات | 27,748 |
| تعداد مشاهده مقاله | 15,457,096 |
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The healing effect of biodegradable scaffolds treated with bone-marrow obtained mesenchymal stem cells on major tendon damage in the dog as a model | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 19 شهریور 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.359751.2470 | ||
| نویسندگان | ||
Abdulsatar Salman Hamza  ؛ Qayes Traef Ali؛ Rafid Hadi Farman
| ||
| Department of Surgery and Obstetrics, College of Veterinary Medicine, University of Al-Qadisiyah/ Iraq | ||
| چکیده | ||
| The present study planned to evaluate the implantation of decellularized small intestinal submucosa- SIS-ECM seeded with bone marrow mesenchymal stem cells (BM-MSCs) to repair full-thickness Achilles tendon defect. Twenty healthy adult 8-12 months old stray dogs (15±3kg of weight) were used in this study under an aseptic environment and general anesthesia. A 1. 5 cm segment long segmented-based resection was performed in the mid-substance of the Achilles tendon in the control group (n=10) left without treatment. While, in the treated group (n=10), the defect of the tendon was bridged the stumps with Decellularized- SIS seeded with BM-MSCs (5 ×106) cells implanted, then suture the stumps of the tendon using the modified Kessler technique (4-0) polypropylene thread. The biomechanical observations of the tendon defect showed an increase in the tensile strength with a significant (p≤0.05) difference in the combination group compared to the control animals. Histopathological observations of biopsies harvested after (the 4th, 8th, and 12th weeks) revealed that the implanted graft seeded with MSCs enhanced high-quality cellular infiltration and better host tissue healing. Similar to the normal tendon, a dense organized collagenous tissue with high cellularity and vascularity was seen due to the presence of the remodeled ECM. However, the arrangement of collagen-fiber-derived connective tissue appeared to be more dominant than that in the combination group, with less adhesion on the 12th week post-treatment. These findings suggest that the BM-MSCs inoculated with SIS can be employed to repair a damaged Achilles tendon due to the fact that this combination enhances the regeneration of the affected tendon. | ||
| کلیدواژه‌ها | ||
| Bone marrow؛ Mesenchymal stem cells-Small intestinal submucosa (SIS)؛ Dog؛ Implantation؛ Tendon-healing | ||
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آمار تعداد مشاهده مقاله: 9 |
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