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Al-Saedi, H. F, Al-Notazy, M. R, Ramadhan, M. A, Khaled Younis Albahadly, W. (1401). Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model. سامانه مدیریت نشریات علمی, 77(5), 1945-1952. doi: 10.22092/ari.2022.359728.2463
H. F Al-Saedi; M. R Al-Notazy; M. A Ramadhan; W Khaled Younis Albahadly. "Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1945-1952. doi: 10.22092/ari.2022.359728.2463
Al-Saedi, H. F, Al-Notazy, M. R, Ramadhan, M. A, Khaled Younis Albahadly, W. (1401). 'Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model', سامانه مدیریت نشریات علمی, 77(5), pp. 1945-1952. doi: 10.22092/ari.2022.359728.2463
Al-Saedi, H. F, Al-Notazy, M. R, Ramadhan, M. A, Khaled Younis Albahadly, W. Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model. سامانه مدیریت نشریات علمی, 1401; 77(5): 1945-1952. doi: 10.22092/ari.2022.359728.2463

Pharmaceutical Characterization and in vivo Evaluation of the Possible Anti-Inflammatory Effect of Topical Allopurinol Gel in an Animal Model

Archives of Razi Institute
مقاله 54، دوره 77، شماره 5، آذر و دی 2022، صفحه 1945-1952    اصل مقاله (979.4 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.359728.2463
نویسندگان
H. F Al-Saedi* 1؛ M. R Al-Notazy2؛ M. A Ramadhan3؛ W Khaled Younis Albahadly1
1University of Al-Ameed, College of Pharmacy, Department of Pharmacology, Karbala, Iraq
2Al-Manara University College, Department of Pharmacology, Misan, Iraq
3University of Misan, College of Medicine, Department of Pathology, Misan, Iraq
چکیده
Dermatitis, like inflammation, is a group of common dermatological symptoms and may be associated with systemic and skin diseases. The objective of the current study is to evaluate the potential anti-inflammatory effect of the topical allopurinol against inflammation like skin dermatitis induced by1-isobutyl-1H-imidazo [4,5-c]quinolin-4-amine (IQA) in mice model. The current study allocated the thirty-two mice into four groups (n=8) as follows: i) control group, mice where a white petroleum jelly base applied topically on the dorsal of mice once daily; ii) induction group, mice were received IQA cream (62.5 mg) of (5%) on their back once daily; and iii) the treatment group, mice were treated with both (62.5 mg) of (5%) IQA and (5%) allopurinol gel topically; the betamethasone group, mice were treated with both (62.5 mg) of (5%) IQA and betamethasone ointment topically. All groups were treated daily for seven days period. The allopurinol-treated group exerted non-significant differences compared with the induction group in both visional and histopathological changes. The present study revealed that the allopurinolgel (5%) did not affect skin inflammation- induced by IQA in the laboratory mice.
کلیدواژه‌ها
Allopurinol؛ IQA؛ Inflammation؛ Dermatitis
مراجع
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