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Al-Humairi, R. M. A, Hashim Mohammad, T, Thanoon Ahmed, S, Ad’hiah, A. H. (1401). Systemic Interleukin-6 Response after Intravesical Instillation of Bacillus Calmette-Guérin and Mitomycin C in Superficial Bladder Cancer. سامانه مدیریت نشریات علمی, 78(1), 353-360. doi: 10.22092/ari.2022.358957.2344
R. M. A Al-Humairi; T Hashim Mohammad; S Thanoon Ahmed; A. H Ad’hiah. "Systemic Interleukin-6 Response after Intravesical Instillation of Bacillus Calmette-Guérin and Mitomycin C in Superficial Bladder Cancer". سامانه مدیریت نشریات علمی, 78, 1, 1401, 353-360. doi: 10.22092/ari.2022.358957.2344
Al-Humairi, R. M. A, Hashim Mohammad, T, Thanoon Ahmed, S, Ad’hiah, A. H. (1401). 'Systemic Interleukin-6 Response after Intravesical Instillation of Bacillus Calmette-Guérin and Mitomycin C in Superficial Bladder Cancer', سامانه مدیریت نشریات علمی, 78(1), pp. 353-360. doi: 10.22092/ari.2022.358957.2344
Al-Humairi, R. M. A, Hashim Mohammad, T, Thanoon Ahmed, S, Ad’hiah, A. H. Systemic Interleukin-6 Response after Intravesical Instillation of Bacillus Calmette-Guérin and Mitomycin C in Superficial Bladder Cancer. سامانه مدیریت نشریات علمی, 1401; 78(1): 353-360. doi: 10.22092/ari.2022.358957.2344

Systemic Interleukin-6 Response after Intravesical Instillation of Bacillus Calmette-Guérin and Mitomycin C in Superficial Bladder Cancer

Archives of Razi Institute
مقاله 44، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 353-360    اصل مقاله (576.54 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358957.2344
نویسندگان
R. M. A Al-Humairi1؛ T Hashim Mohammad1؛ S Thanoon Ahmed1؛ A. H Ad’hiah2
1Department of Biology, College of Science for Women, University of Baghdad, Baghdad, Iraq
2Tropical-Biological Research Unit, College of Science, University of Baghdad, Baghdad, Iraq
چکیده
Interleukin-6 (IL-6) is proposed to play a significant role in pathogenesis of urinary bladder cancer (UBC). This role may be influenced by chemotherapy (mitomycin C; MMC) or immunotherapy (Bacillus Calmette-Guérin; BCG). A case-control study was conducted to determine IL-6 levels in serum of newly diagnosed cases (NDC) of superficial UBC, as well as in patients treated with MMC or BCG intravesical instillation. A total sample of 111 patients (36 NDC, 45 MMC and 30 BCG) was included, as well as a control group of 107 healthy controls (HC). IL-6 was detected by enzyme-linked immunosorbent assay. Results revealed that median levels of IL-6 were significantly elevated in NDC group (15.8 pg/mL; P<0.001) compared to MMC and BCG groups (7.5 and 5.3 pg/mL, respectively) or HC (4.4 pg/mL); while, there were no significant differences between the latter three groups (MMC, BCG and HC). Receiver operating characteristic curve analysis revealed that IL-6 is a very good predictor of UBC in NDC group versus HC (area under the curve=0.885; 95% confidence interval=0.828-0.942; P<0.001; cut-off value=10.5 pg/mL; Youden index=0.62; sensitivity=80.6%; specificity=81.3%). Logistic regression analysis confirmed this significance and IL-6 was associated with a higher risk of UBC (odds ratio=1.18; 95% confidence interval=1.11-1.26; P<0.001). In conclusion, this study indicated that IL-6 level was upregulated in serum of NDC of UBC. Further, IL-6 level was restored to normal levels after intravesical instillation of MMC or BCG.
کلیدواژه‌ها
Urinary bladder cancer؛ Interleukin-6؛ Mitomycin C؛ Bacillus Calmette-Guérin
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