اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,846
تعداد مقالات32,300
تعداد مشاهده مقاله41,387,161
تعداد دریافت فایل اصل مقاله18,562,192
Shamki Fayyad, N, Risan Al-Rikabi, H. (1401). Angiotensin-Converting Enzyme 2 (ACE2) Gene Polymorphism in Patients with Type 2 Diabetes (T2DM) in Thi-Qar, Iraq. سامانه مدیریت نشریات علمی, 77(6), 2365-2370. doi: 10.22092/ari.2022.358736.2294
N Shamki Fayyad; H Risan Al-Rikabi. "Angiotensin-Converting Enzyme 2 (ACE2) Gene Polymorphism in Patients with Type 2 Diabetes (T2DM) in Thi-Qar, Iraq". سامانه مدیریت نشریات علمی, 77, 6, 1401, 2365-2370. doi: 10.22092/ari.2022.358736.2294
Shamki Fayyad, N, Risan Al-Rikabi, H. (1401). 'Angiotensin-Converting Enzyme 2 (ACE2) Gene Polymorphism in Patients with Type 2 Diabetes (T2DM) in Thi-Qar, Iraq', سامانه مدیریت نشریات علمی, 77(6), pp. 2365-2370. doi: 10.22092/ari.2022.358736.2294
Shamki Fayyad, N, Risan Al-Rikabi, H. Angiotensin-Converting Enzyme 2 (ACE2) Gene Polymorphism in Patients with Type 2 Diabetes (T2DM) in Thi-Qar, Iraq. سامانه مدیریت نشریات علمی, 1401; 77(6): 2365-2370. doi: 10.22092/ari.2022.358736.2294

Angiotensin-Converting Enzyme 2 (ACE2) Gene Polymorphism in Patients with Type 2 Diabetes (T2DM) in Thi-Qar, Iraq

Archives of Razi Institute
مقاله 43، دوره 77، شماره 6، بهمن و اسفند 2022، صفحه 2365-2370    اصل مقاله (369.41 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358736.2294
نویسندگان
N Shamki Fayyad؛ H Risan Al-Rikabi*
Biology Department. College of Education for Pure Science, University of Thi-Qar University, Thi-Qar, Iraq
چکیده
The increased levels of blood glucose associated with genetic and/or environmental risk factors have been known as Type 2 diabetes mellitus (T2D). T2D is categorized as a dangerous clinical syndrome for global public health. It has been well-documented that several candidate genes are functionally associated with T2D. One of the candidate genes linked to T2D is named Angiotensin-converting enzyme 2 (ACE2). Therefore, this study aimed to evaluate the relationship between ACE2 gene polymorphism and the development of T2D in Iraq. This study includes 150 participants (100) T2D patients and 50 healthy participants as a control group. Through the analysis of the recorded data, 78% were nonsmokers, while the rest were smokers. The current study found 61% of T2D patients suffer from hypertension (P-value=0.028). In this study, 80% of patients have the GG genotype. However, 26% have the GA genotype without a significant difference between patients and the control group (OR=0.78). Mutations in the ACE2 gene were recorded in the gene bank with accession numbers LC656363, LC656364, LC656365, LC656366, LC656367 and LC656368. The current study showed a relationship between mutations and polymorphisms in the ACE2 gene and type 2 diabetes mellitus. The polymorphisms, deletion and insertion mutations had an important role in the pathophysiology of type 2 diabetes mellitus. The study recorded some mutations in the Clinical Variation website at NCBI's National Center for Biotechnology Information. The current study showed a relationship between smoking and the risk of developing type 2 diabetes. The current study's findings indicated that mutations affecting the three encoded genes could directly cause impaired insulin production in people with type 2 diabetes.
کلیدواژه‌ها
ACE2؛ PCR؛ Type 2 diabetes mellitus؛ Thi Qar population
سایر فایل های مرتبط با مقاله
مراجع
  1. Danaei G, Singh GM, Paciorek CJ, Lin JK, Cowan MJ, Finucane MM, et al. The global cardiovascular risk transition: associations of four metabolic risk factors with national income, urbanization, and Western diet in 1980 and 2008. Circulation. 2013;127(14):1493-502.
  2. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103(2):137-49.
  3. Huldani H, Jasim SA, Bokov DO, Abdelbasset WK, Shalaby MN, Thangavelu L, et al. Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases. Int Immunopharmacol. 2022;106:108634.
  4. Karki R, Pandya D, Elston RC, Ferlini C. Defining “mutation” and “polymorphism” in the era of personal genomics. BMC Med Genom. 2015;8(1):1-7.
  5. Teama S. DNA polymorphisms: DNA-based molecular markers and their application in medicine. Genetic Diversity and Disease Susceptibility. 2018;25.
  6. Cho N, Shaw J, Karuranga S, Huang Y, da Rocha Fernandes J, Ohlrogge A, et al. IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018;138:271-81.
  7. Leslie RD, Palmer J, Schloot NC, Lernmark A. Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia. 2016;59(1):13-20.
  8. Yang M, Zhao J, Xing L, Shi L. The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients. J Renin Angiotensin Aldosterone Syst. 2015;16(4):1240-4.
  9. Benjafield AV, Wang WY, Morris BJ. No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. Am J Hypertens. 2004;17(7):624-8.
  10. Huang W, Yang W, Wang Y, Zhao Q, Gu D, Chen R. Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese. J Hum Hypertens. 2006;20(12):968-71.
  11. Doris PA. Hypertension genetics, single nucleotide polymorphisms, and the common disease: common variant hypothesis. Hypertension. 2002;39(2):323-31.
  12. Alghamri MS, Weir NM, Anstadt MP, Elased KM, Gurley SB, Morris M. Enhanced angiotensin II-induced cardiac and aortic remodeling in ACE2 knockout mice. J Cardiovasc Pharmacol. 2013;18(2):138-51.
  13. Olegovich Bokov D, Jalil AT, Alsultany FH, Mahmoud MZ, Suksatan W, Chupradit S, et al. Ir-decorated gallium nitride nanotubes as a chemical sensor for recognition of mesalamine drug: a DFT study. Mol Simul. 2022:1-10.
  14. Zhou J-B, Yang J-K. Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension. Journal of the Renin-Angiotensin-Aldosterone System. 2009;10(1):31-4.
  15. Elihimas Júnior UF, Elihimas HCdS, Lemos VM, Leão MdA, Sá MPBdO, França EETd, et al. Smoking as risk factor for chronic kidney disease: systematic review. J Bras Nefrol. 2014;36:519-28.
  16. Zhang Y, Jia N, Hu F, Fan N, Guo X, Du H, et al. Association of single-nucleotide polymorphisms in the RAGE gene and its gene-environment interactions with diabetic nephropathy in Chinese patients with type 2 diabetes. Oncotarget. 2017;8(57):96885.
  17. Cai W, Li J, Xu J-X, Liu Y, Zhang W, Xiao J-R, et al. Association of 2184AG polymorphism in the RAGE gene with diabetic nephropathy in Chinese patients with type 2 diabetes. J Diabetes Res. 2015;2015.
  1. Ansari MJ, Jasim SA, Taban TZ, Bokov DO, Shalaby MN, Al-Gazally ME, et al. Anticancer drug-loading capacity of green synthesized porous magnetic iron nanocarrier and cytotoxic effects against human cancer cell line. J Clust Sci. 2022:1-11.
  2. Elsheikh M, Casadei B, Conway G, Wass J. Hypertension is a major risk factor for aortic root dilatation in women with Turner's syndrome. Clin Endocrinol. 2001;54(1):69-73.
  1. Liu C, Li Y, Guan T, Lai Y, Shen Y, Zeyaweiding A, et al. ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus. Cardiovasc Diabetol. 2018;17(1):1-11.
آمار
تعداد مشاهده مقاله: 14,610
تعداد دریافت فایل اصل مقاله: 353


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب