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Muhsen M Ali, Z, Ghaith Sachit, H, Jaafar Hussein, M, Mohammed Ali, S. H, Mohammed Al-Alwany, S. H, Khalil Hussein, A. (1401). Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients. سامانه مدیریت نشریات علمی, 77(6), 2299-2306. doi: 10.22092/ari.2022.358617.2267
Z Muhsen M Ali; H Ghaith Sachit; M Jaafar Hussein; S. H Mohammed Ali; S. H Mohammed Al-Alwany; A Khalil Hussein. "Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients". سامانه مدیریت نشریات علمی, 77, 6, 1401, 2299-2306. doi: 10.22092/ari.2022.358617.2267
Muhsen M Ali, Z, Ghaith Sachit, H, Jaafar Hussein, M, Mohammed Ali, S. H, Mohammed Al-Alwany, S. H, Khalil Hussein, A. (1401). 'Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients', سامانه مدیریت نشریات علمی, 77(6), pp. 2299-2306. doi: 10.22092/ari.2022.358617.2267
Muhsen M Ali, Z, Ghaith Sachit, H, Jaafar Hussein, M, Mohammed Ali, S. H, Mohammed Al-Alwany, S. H, Khalil Hussein, A. Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients. سامانه مدیریت نشریات علمی, 1401; 77(6): 2299-2306. doi: 10.22092/ari.2022.358617.2267

Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients

Archives of Razi Institute
مقاله 35، دوره 77، شماره 6، بهمن و اسفند 2022، صفحه 2299-2306    اصل مقاله (611.3 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358617.2267
نویسندگان
Z Muhsen M Ali1؛ H Ghaith Sachit2؛ M Jaafar Hussein3؛ S. H Mohammed Ali4؛ S. H Mohammed Al-Alwany* 5؛ A Khalil Hussein6
1Faculty of Dentistry, Al-Rafdain University College, Baghdad (00964), Iraq
2College of Dentistry, University of Al_Mustansiriya, Baghdad, Iraq
3Islamic University, Baghdad, Iraq
4College of Medicine, University of Baghdad, Baghdad, Iraq
5College of Science, University of Babylon, Babylon, Iraq
6Al-Mustaqbal University College, Babylon, Iraq
چکیده
Colorectal cancer is ranked to have high mortality among most malignancies worldwide. In the adult population, the seroprevalence rates of the John Cunningham virus (JCV) range from 70% to 90%. Recently the association for JCV in many malignant tumours have been reported worldwide, including colonic and rectum cancers. Interleukin-1β (IL-1β) can promote tumour growth where it is abundant in the tumour microenvironment, and its up-regulation is considered a poor prognostic feature in different types of solid tumours, including colon malignancies. One hundred tissue biopsies belonged to 50 patients with colorectal cancers and 30 benign colonic tumour patients, and 20 colorectal control tissues were enrolled in this study. JCV was detected via chromogenic in situ hybridization (CISH), while IL-1 beta was detected by immunohistochemistry (IHC). The recorded data showed that 21 out of 50 (42%) tissue samples with colorectal carcinoma showed positive CISH reactions for JCV DNA in this study. The benign colorectal tumours group revealed positive signals in 2 out of 30 tissues representing 6.7% of this group. Lastly, no control tissues showed positive signals for the JCV -CISH test. The positive signals of IL-1 Beta-IHC detection were found in 26 out of 50 (52 %) colorectal carcinoma tissues, while in the benign colorectal tumour was 43.3% (13 out of 30) and in AHC was 20% (4 out of 20 tissues). The high rates of JCV infection in this group of Iraqi patients with colonic adenocarcinoma in concordance with IL-1 Beta expression could play an essential role in the development and progression of these malignant tumours along with benign colonic tumours. To analyze the concordant expression of IL-1 beta gene and JCV in issues from a group of Iraqi patients with colonic adenocarcinomas.
کلیدواژه‌ها
In situ hybridization؛ IL1 beta؛ Immunohistochemistry
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مراجع
  1. Wong MC, Ding H, Wang J, Chan PS, Huang J. Prevalence and risk factors of colorectal cancer in Asia. Intest Res. 2019;17(3):317.
  2. Migliore L, Migheli F, Spisni R, Coppedè F. Genetics, cytogenetics, and epigenetics of colorectal cancer. J Biomed Biotechnol. 2011;2011.
  3. Prado JCM, Monezi TA, Amorim AT, Lino V, Paladino A, Boccardo E. Human polyomaviruses and cancer: an overview. Clinics. 2018;73.
  4. Ahye N, Bellizzi A, May D, Wollebo HS. The role of the JC virus in central nervous system tumorigenesis. Int J Mol Sci. 2020;21(17):6236.
  5. Karpinski P, Myszka A, Ramsey D, Kielan W, Sasiadek MM. Detection of viral DNA sequences in sporadic colorectal cancers in relation to CpG island methylation and methylator phenotype. Tumor Biol. 2011;32(4):653-9.
  6. Adekoya TO, Richardson RM. Cytokines and chemokines as mediators of prostate cancer metastasis. Int J Mol Sci. 2020;21(12):4449.
  7. Xu D, Mu R, Wei X. The roles of IL-1 family cytokines in the pathogenesis of systemic sclerosis. Front Immunol. 2019:2025.
  8. Mager LF, Wasmer M-H, Rau TT, Krebs P. Cytokine-induced modulation of colorectal cancer. Front Oncol. 2016;6:96.
  9. Wang Y, Wang K, Han G, Wang R, Xiao H, Hou C, et al. Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis. Mucosal Immunol. 2014;7(5):1106-15.
  10. Tu S, Bhagat G, Cui G, Takaishi S, Kurt-Jones EA, Rickman B, et al. Overexpression of interleukin-1β induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice. Cancer cell. 2008;14(5):408-19.
  11. Matsuo Y, Sawai H, Ma J, Xu D, Ochi N, Yasuda A, et al. IL‐1α secreted by colon cancer cells enhances angiogenesis: The relationship between IL‐1α release and tumor cells' potential for liver metastasis. J Surg Oncol. 2009;99(6):361-7.
  12. Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell. 2012;149(6):1192-205.
  13. Rawla P, Sunkara T, Barsouk A. Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors. Prz Gastroenterol. 2019;14(2):89.
  14. Ava T. A study of K-ras in colorectal carcinoma in Kurdistan region_Iraq. Iraq: Hawler medical university; 2011.
  15. Kifah H. Cellular proliferation & angiogenesis in colonic carcinoma by application of immunohistochemistry and insituhybridization: Baghdad university; 2008.
  16. Almohana SJ, Alhelu SA, Aldabagh LA, Yahya A. Relative Risk of Colonic Cancer Post Cholecystectomy in Najaf. Med J Babylon. 2014;11(2).
  17. Mármol I, Sánchez-de-Diego C, Pradilla Dieste A, Cerrada E, Rodriguez Yoldi MJ. Colorectal carcinoma: a general overview and future perspectives in colorectal cancer. Int J Mol Sci. 2017;18(1):197.
  18. Nikolaou S, Qiu S, Fiorentino F, Rasheed S, Tekkis P, Kontovounisios C. The prognostic and therapeutic role of hormones in colorectal cancer: a review. Mol Biol Rep. 2019;46(1):1477-86.
  19. Munteanu I, Mastalier B. Genetics of colorectal cancer. J Med Life. 2014;7(4):507.
  20. Delbue S, Comar M, Ferrante P. Review on the role of the human Polyomavirus JC in the development of tumors. Infect Agents Cancer. 2017;12(1):1-14.
  21. Coelho TR, Almeida L, Lazo PA. JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process? Virol J. 2010;7(1):1-8.
  22. Ferenczy MW, Marshall LJ, Nelson CD, Atwood WJ, Nath A, Khalili K, et al. Molecular biology, epidemiology, and pathogenesis of progressive multifocal leukoencephalopathy, the JC virus-induced demyelinating disease of the human brain. Clin Microbiol Rev. 2012;25(3):471-506.
  23. Sinagra E, Raimondo D, Gallo E, Stella M, Cottone M, Orlando A, et al. Could JC virus provoke metastasis in colon cancer? World J Gastroenterol. 2014;20(42):15745.
  24. Casini B, Borgese L, Del Nonno F, Galati G, Izzo L, Caputo M, et al. Presence and incidence of DNA sequences of human polyomaviruses BKV and JCV in colorectal tumor tissues. Anticancer Res. 2005;25(2A):1079-85.
  25. Antonic V, Stojadinovic A, Kester KE, Weina PJ, Brücher BL, Protic M, et al. Significance of infectious agents in colorectal cancer development. J Cancer. 2013;4(3):227.
  26. Enam S, Del Valle L, Lara C, Gan D-D, Ortiz-Hidalgo C, Palazzo JP, et al. Association of human polyomavirus JCV with colon cancer: evidence for interaction of viral T-antigen and β-catenin. Cancer Res. 2002;62(23):7093-101.
  27. Boland CR. Evidence for an association between JC virus and colorectal neoplasia. Cancer Epidemiol Biomarkers Prev. 2004;13(12):2285-6.
  28. Ricciardiello L, Baglioni M, Giovannini C, Pariali M, Cenacchi G, Ripalti A, et al. Induction of chromosomal instability in colonic cells by the human polyomavirus JC virus. Cancer Res. 2003;63(21):7256-62.
  29. Voronov E, Apte RN. IL-1 in colon inflammation, colon carcinogenesis and invasiveness of colon cancer. Cancer Microenviron. 2015;8(3):187-200.
  30. Li Y, Wang L, Pappan L, Galliher-Beckley A, Shi J. IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation. Mol Cancer. 2012;11(1):1-13.
  1. Haabeth OAW, Lorvik KB, Yagita H, Bogen B, Corthay A. Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells. Oncoimmunology. 2016;5(1):e1039763.
  2. Dmitrieva-Posocco O, Dzutsev A, Posocco DF, Hou V, Yuan W, Thovarai V, et al. Cell-type-specific responses to interleukin-1 control microbial invasion and tumor-elicited inflammation in colorectal cancer. Immunity. 2019;50(1):166-80. e7.
  3. Castaño Z, San Juan BP, Spiegel A, Pant A, DeCristo MJ, Laszewski T, et al. IL-1β inflammatory response driven by primary breast cancer prevents metastasis-initiating cell colonization. Nat Cell Biol. 2018;20(9):1084-97.
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