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Muhsen M Ali, Z, Ghaith Sachit, H, Jaafar Hussein, M, Mohammed Ali, S. H, Mohammed Al-Alwany, S. H, Khalil Hussein, A. (1401). Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients. سامانه مدیریت نشریات علمی, 77(6), 2299-2306. doi: 10.22092/ari.2022.358617.2267
Z Muhsen M Ali; H Ghaith Sachit; M Jaafar Hussein; S. H Mohammed Ali; S. H Mohammed Al-Alwany; A Khalil Hussein. "Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients". سامانه مدیریت نشریات علمی, 77, 6, 1401, 2299-2306. doi: 10.22092/ari.2022.358617.2267
Muhsen M Ali, Z, Ghaith Sachit, H, Jaafar Hussein, M, Mohammed Ali, S. H, Mohammed Al-Alwany, S. H, Khalil Hussein, A. (1401). 'Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients', سامانه مدیریت نشریات علمی, 77(6), pp. 2299-2306. doi: 10.22092/ari.2022.358617.2267
Muhsen M Ali, Z, Ghaith Sachit, H, Jaafar Hussein, M, Mohammed Ali, S. H, Mohammed Al-Alwany, S. H, Khalil Hussein, A. Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients. سامانه مدیریت نشریات علمی, 1401; 77(6): 2299-2306. doi: 10.22092/ari.2022.358617.2267

Molecular Interplay of John Cunningham Virus with Interleukin 1 Beta in Colorectal Carcinomatous Tissues from a Group of Iraqi Patients

Archives of Razi Institute
مقاله 35، دوره 77، شماره 6، بهمن و اسفند 2022، صفحه 2299-2306    اصل مقاله (611.3 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358617.2267
نویسندگان
Z Muhsen M Ali1؛ H Ghaith Sachit2؛ M Jaafar Hussein3؛ S. H Mohammed Ali4؛ S. H Mohammed Al-Alwany* 5؛ A Khalil Hussein6
1Faculty of Dentistry, Al-Rafdain University College, Baghdad (00964), Iraq
2College of Dentistry, University of Al_Mustansiriya, Baghdad, Iraq
3Islamic University, Baghdad, Iraq
4College of Medicine, University of Baghdad, Baghdad, Iraq
5College of Science, University of Babylon, Babylon, Iraq
6Al-Mustaqbal University College, Babylon, Iraq
چکیده
Colorectal cancer is ranked to have high mortality among most malignancies worldwide. In the adult population, the seroprevalence rates of the John Cunningham virus (JCV) range from 70% to 90%. Recently the association for JCV in many malignant tumours have been reported worldwide, including colonic and rectum cancers. Interleukin-1β (IL-1β) can promote tumour growth where it is abundant in the tumour microenvironment, and its up-regulation is considered a poor prognostic feature in different types of solid tumours, including colon malignancies. One hundred tissue biopsies belonged to 50 patients with colorectal cancers and 30 benign colonic tumour patients, and 20 colorectal control tissues were enrolled in this study. JCV was detected via chromogenic in situ hybridization (CISH), while IL-1 beta was detected by immunohistochemistry (IHC). The recorded data showed that 21 out of 50 (42%) tissue samples with colorectal carcinoma showed positive CISH reactions for JCV DNA in this study. The benign colorectal tumours group revealed positive signals in 2 out of 30 tissues representing 6.7% of this group. Lastly, no control tissues showed positive signals for the JCV -CISH test. The positive signals of IL-1 Beta-IHC detection were found in 26 out of 50 (52 %) colorectal carcinoma tissues, while in the benign colorectal tumour was 43.3% (13 out of 30) and in AHC was 20% (4 out of 20 tissues). The high rates of JCV infection in this group of Iraqi patients with colonic adenocarcinoma in concordance with IL-1 Beta expression could play an essential role in the development and progression of these malignant tumours along with benign colonic tumours. To analyze the concordant expression of IL-1 beta gene and JCV in issues from a group of Iraqi patients with colonic adenocarcinomas.
کلیدواژه‌ها
In situ hybridization؛ IL1 beta؛ Immunohistochemistry
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