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Saedan Kutin, A, Jasib Almzaiel, A, Al-Badry, A. (1401). Sirtuin 1 Expression Enhances the Inflammatory Response in Allergic Rhinitis Combined with Asthma. سامانه مدیریت نشریات علمی, 77(6), 2385-2393. doi: 10.22092/ari.2022.358614.2264
A Saedan Kutin; A Jasib Almzaiel; A Al-Badry. "Sirtuin 1 Expression Enhances the Inflammatory Response in Allergic Rhinitis Combined with Asthma". سامانه مدیریت نشریات علمی, 77, 6, 1401, 2385-2393. doi: 10.22092/ari.2022.358614.2264
Saedan Kutin, A, Jasib Almzaiel, A, Al-Badry, A. (1401). 'Sirtuin 1 Expression Enhances the Inflammatory Response in Allergic Rhinitis Combined with Asthma', سامانه مدیریت نشریات علمی, 77(6), pp. 2385-2393. doi: 10.22092/ari.2022.358614.2264
Saedan Kutin, A, Jasib Almzaiel, A, Al-Badry, A. Sirtuin 1 Expression Enhances the Inflammatory Response in Allergic Rhinitis Combined with Asthma. سامانه مدیریت نشریات علمی, 1401; 77(6): 2385-2393. doi: 10.22092/ari.2022.358614.2264

Sirtuin 1 Expression Enhances the Inflammatory Response in Allergic Rhinitis Combined with Asthma

Archives of Razi Institute
مقاله 46، دوره 77، شماره 6، بهمن و اسفند 2022، صفحه 2385-2393    اصل مقاله (709.98 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358614.2264
نویسندگان
A Saedan Kutin* 1؛ A Jasib Almzaiel1؛ A Al-Badry2
1Department of Medical Chemistry, College of Medicine, University of AL-Qadisiyah, Al-Diywaniyah, Iraq
2Deprtment of Allergic and Asthmatic Diseases, Al-Dywaniyah Education Hospital, Al-Diywaniyah, Iraq
چکیده
Asthma (ASTH) is a chronic inflammatory disease that affects the lung airway and leads to occasional breathing difficulties. Previous studies have presented links between allergic rhinitis (AR) and ASTH. Recently, it was suggested that SIRT1, a NAD-dependent class III histone deacetylase protein, was involved in the pathogenesis of ASTH. However, the protective roles of SRIT1 in ASTH are still unclear. This study aimed to investigate the role of SRIT1 in the inflammatory response in ASTH and AR. The study involved 30 patients with ASTH, 40 patients with AR, 40 ASTH with AR, and 30 healthy subjects as control. A 5 ml blood sample was taken from all the participants. 1 ml was used for complete blood count (CBC) and Neutrophils/lymphocytes ratio analysis. Serum was separated from other 4 ml of blood by centrifugation for SRIT1 and exotoxin (CCL11) assays analyzed by ELISA. Nasal fluids (0.5 ml) were also collected from all patient groups and controlled to measure SRIT1 and CCL11 by ELISA. The results showed a significant increase in eosinophil counts and Neutrophils/ lymphocytes ratio (N/L) in ASTH with the AR group compared to other patient groups and control (P<0.05). High SIRT1 and CCL11 levels were observed in serum and nasal patient groups compared to control (P<0.05). These findings may go some way towards explaining the numerous roles of SRIT1 in patients with ASTH. SIRT1 may regulate CCL11 levels after that, affecting ASTH pathogenesis. SRIT 1 in nasal secretion is a new biological characteristic of pulmonary airway diseases.
کلیدواژه‌ها
Immune System؛ Pulmonary Diseases؛ Gene Expression
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مراجع
  1. Schatz M, Rosenwasser L. The allergic asthma phenotype. J Allergy Clin Immunol. 2014;2(6):645-8.
  2. Dunn R, Busse P, Wechsler M. Asthma in the elderly and late‐onset adult asthma. Allergy. 2018;73(2):284-94.
  3. Wang YC, Jaakkola M, Lajunen T, Lai CH, Jaakkola J. Asthma‐COPD overlap syndrome among subjects with newly diagnosed adult‐onset asthma. Allergy. 2018;73(7):1554-7.
  4. Eiwegger T, Soyka MB, Leung DY, Akdis CA, Bacharier L, Cunningham-Rundles C. Allergic Rhinitis. Pediatric Allergy, E-Book: Principles and Practice. 2020;135.
  5. Campo P, Eguiluz‐Gracia I, Bogas G, Salas M, Plaza Serón C, Pérez N, et al. Local allergic rhinitis: implications for management. Clin Exp Allergy. 2019;49(1):6-16.
  6. Davraj K, Yadav M, Chappity P, Sharma P, Grover M, Sharma S, et al. Nasal Physiology and Sinusitis. Essentials of Rhinology: Springer; 2021. p. 49-101.
  7. Satyaraj E, Wedner HJ, Bousquet J. Keep the cat, change the care pathway: a transformational approach to managing Fel d 1, the major cat allergen. Allergy. 2019;74:5-17.
  8. Pothirat C, Chaiwong W. A Real-World Effectiveness of Subcutaneous Immunotherapy on the Cost of Medication, Allergic Rhinitis, and Asthma Exacerbations, as well as Upper Respiratory Tract Infection in Subjects with Allergic Rhinitis with or without Asthma: A Retrospective Pilot Study. Medicina. 2021;57(11):1229.
  9. Ferreira LKP, Ferreira LAP, Monteiro TM, Bezerra GC, Bernardo LR, Piuvezam MR. Combined allergic rhinitis and asthma syndrome (CARAS). Int Immunopharmacol. 2019;74:105718.
  10. Naafs M. The burden of allergic rhinitis: a mini-review. Glob J Oto. 2018;13(1):555854.
  11. Eddy RL. Structure and Function of Asthma Evaluated Using Pulmonary Imaging. 2020.
  12. Wang C, Liu Y, Zhu Y, Kong C. Functions of mammalian SIRT4 in cellular metabolism and research progress in human cancer. Oncol Lett. 2020;20(4):1.
  13. Boskabady MH, Amin F, Shakeri F. The effect of Curcuma longa on inflammatory mediators and immunological, oxidant, and antioxidant biomarkers in asthmatic rats. Evid-Based Complement Altern Med. 2021;2021.
  14. Ito JT, Lourenço JD, Righetti RF, Tibério IF, Prado CM, Lopes FD. Extracellular matrix component remodeling in respiratory diseases: what has been found in clinical and experimental studies? Cells. 2019;8(4):342.
  15. Matucci A, Vultaggio A, Maggi E, Kasujee I. Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question? Respir Res. 2018;19(1):1-10.
  16. Krynytska I, Kucher S, Tokarskyy O, Koval M. The association of angiotensin-converting enzyme gene insertion/deletion polymorphism with bronchial asthma. Pol Merkur Lekarski. 2021;49(294):391-3.
  17. Lee L-Y, Hew GSY, Mehta M, Shukla SD, Satija S, Khurana N, et al. Targeting eosinophils in respiratory diseases: Biological axis, emerging therapeutics and treatment modalities. Life Sci. 2021;267:118973.
  18. Nakagome K, Nagata M. Involvement and possible role of eosinophils in asthma exacerbation. Front Immunol. 2018:2220.
  19. Zhong L, Simard MJ, Huot J. Endothelial microRNAs regulating the NF‐κB pathway and cell adhesion molecules during inflammation. FASEB J. 2018;32(8):4070-84.
  20. Menzella F, Ghidoni G, Galeone C, Capobelli S, Scelfo C, Facciolongo NC. Immunological aspects related to viral infections in severe asthma and the role of omalizumab. Biomedicines. 2021;9(4):348.
  21. Merad M, Martin JC. Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol. 2020;20(6):355-62.
  22. Robertson TF, Huttenlocher A. Real‐time imaging of inflammation and its resolution: It’s apparent because it’s transparent. Immunol Rev. 2022.
  23. Shao S, Fang H, Dang E, Xue K, Zhang J, Li B, et al. Neutrophil extracellular traps promote inflammatory responses in psoriasis via activating epidermal TLR4/IL-36R crosstalk. Front Immunol. 2019;10:746.
  24. De Bondt M, Hellings N, Opdenakker G, Struyf S. Neutrophils: underestimated players in the pathogenesis of Multiple Sclerosis (MS). Int J Mol Sci. 2020;21(12):4558.
  25. Kienle K, Glaser KM, Eickhoff S, Mihlan M, Knöpper K, Reátegui E, et al. Neutrophils self-limit swarming to contain bacterial growth in vivo. Science. 2021;372(6548):eabe7729.
  26. Wu Y, Li W, Hu Y, Liu Y, Sun X. Suppression of sirtuin 1 alleviates airway inflammation through mTOR‑mediated autophagy. Mol Med Rep. 2020;22(3):2219-26.
  27. Hui B, Hou X, Liu R, Liu X-H, Hu Z. Gypenoside inhibits ox-LDL uptake and foam cell formation through enhancing Sirt1-FOXO1 mediated autophagy flux restoration. Life Sci. 2021;264:118721.
  28. Shi Z, Sun Y, Wang K, Jia J, Yang J, Li Y. Effects of miR-26a/miR-146a/miR-31 on airway inflammation of asthma mice and asthma children. Eur Rev Med Pharmacol Sci. 2019;23(12):5432-40.
  29. Cheng L, Chen J, Fu Q, He S, Li H, Liu Z, et al. Chinese society of allergy guidelines for diagnosis and treatment of allergic rhinitis. Allergy Asthma Immunol Res. 2018;10(4):300-53.
  30. Chen M, Chen Z, Huang D, Sun C, Xie J, Chen T, et al. Myricetin inhibits TNF-α-induced inflammation in A549 cells via the SIRT1/NF-κB pathway. Pulm Pharmacol Ther. 2020;65:102000.
  31. Kytikova OY, Perelman JM, Novgorodtseva TP, Denisenko YK, Kolosov VP, Antonyuk MV, et al. Peroxisome proliferator-activated receptors as a therapeutic target in asthma. PPAR Res. 2020;2020.
  32. Lei H, Sun Y, Quan S. IL‑37 relieves allergic inflammation by inhibiting the CCL11 signaling pathway in a mouse model of allergic rhinitis. Exp Ther Med. 2020;20(4):3114-21.
  33. Branicka O, Jura-Szołtys E, Rogala B, Glück J. Elevated serum level of CD48 in patients with intermittent allergic rhinitis. Int Arch Allergy Immunol. 2021;182(1):39-48.
  1. Sun Z, Vattepu R, Zhang S. Chemokines and Innate Lymphoid Cells in Skin Inflammation. Cells. 2021;10(11):3074.
  2. Rouadi PW, Idriss SA, Naclerio RM, Peden DB, Ansotegui IJ, Canonica GW, et al. Immunopathological features of air pollution and its impact on inflammatory airway diseases (IAD). World Allergy Organ J. 2020;13(10):100467.
  3. Gökkaya M, Damialis A, Nussbaumer T, Beck I, Bounas-Pyrros N, Bezold S, et al. Defining biomarkers to predict symptoms in subjects with and without allergy under natural pollen exposure. J Allergy Clin Immunol. 2020;146(3):583-94.
  4. Berghi NO, Dumitru M, Vrinceanu D, Ciuluvica RC, Simioniuc-Petrescu A, Caragheorgheopol R, et al. Relationship between chemokines and T lymphocytes in the context of respiratory allergies. Exp Ther Med. 2020;20(3):2352-60.
  1. Iype J, Fux M. Basophils Orchestrating Eosinophils’ Chemotaxis and Function in Allergic Inflammation. Cells. 2021;10(4):895.
  2. Khan MA, Alam Q, Haque A, Ashafaq M, Khan MJ, Ashraf GM, et al. Current progress on peroxisome proliferator-activated receptor gamma agonist as an emerging therapeutic approach for the treatment of Alzheimer's disease: an update. Curr Neuropharmacol. 2019;17(3):232-46.
  3. Ong AL, Ramasamy TS. Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. Ageing Res Rev. 2018;43:64-80.
  4. Ren X, Wang Z. High chemokine ligand 11 levels in nasal lavage fluid: A potential predictor of and therapeutic target for murine eosinophilic chronic rhinosinusitis. Life Sci. 2021;271:119218.
  5. Boonpiyathad T, Sözener ZC, Satitsuksanoa P, Akdis CA, editors. Immunologic mechanisms in asthma. Seminars in immunology; 2019: Elsevier.
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