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| تعداد نشریات | 280 |
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| تعداد مقالات | 27,162 |
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Expression of MMP1 and MMP7 in Mice liver after Exposure to AflatoxinB1 using Immunohistochemistry Technique | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 17 خرداد 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.358774.2306 | ||
| نویسنده | ||
Nada H. A. L. Al-Mudallal 
| ||
| Al-Iraqia University, College of Medicine, Medical Microbiology-Department,Baghdad, Iraq | ||
| چکیده | ||
| Mycotoxin is a class of poisonous secondary metabolites generated by filamentous fungi and found in agricultural commodities all over the world. Therefore, the aim of the current study was to investigate how aflatoxin B1 affected hepatic cellular architecture and Matrix metalloproteinase expression in particular (MMP1 and MMP7) in the livers of experimental mice (IHC). A total of sixteen mice (four groups) were studied after being given pure aflatoxin B1 (9mg/kgbw, 6mg/kgbw, and 3mg/kgbw) (produced from Aspergillus flavus) or a control group (not treated). MMP1 and MMP7 expressions were also measured using the MMP1 and MMP7 expression assays (IHC). The degree of liver damage is related to the AFB1 concentration and the duration of exposure. IHC reveals a considerable rise in MMP1 and MMP7 expression in the livers of mice given a maximum concentration of 90% ((9 mg/bwt) pure AFB1), which approached the toxin's effect toxic dosage.MMP1 and MMP7 expression were also increased by AFB1 at dosages of 60 and 30% (6mg/bwt and 3mg/bwt, respectively), although not to the same extent as 90 percent. MMP1 was significantly more expressed than MMP7 compared to control, and AFB1 at 90, 60, and 30 percent concentrations caused changes in hepatic cellular architecture, organisation, and liver tissue damage, as well as dramatically increased MMP1 and MMP7 production in hepatic tissue following treatment. Increased levels of pure aflatoxin B1 will harm liver tissue and MMP1, MMP7 expression. MMP1 was more substantially expressed than MMP7. | ||
| کلیدواژه‌ها | ||
| Matrix metalloproteinases MMP1 and MMP7؛ aflatoxin B1؛ Immunohistochemistry technique | ||
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آمار تعداد مشاهده مقاله: 5 |
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