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AL-Mudhafar, M. A, Nima Mezher, M, Noaman, I. M. (1401). The Association of Angiotensin-Converting Enzyme 2 Polymorphism and SARS-CoV-2 Infection in the Iraqi Population. سامانه مدیریت نشریات علمی, 78(1), 9-14. doi: 10.22092/ari.2022.358871.2323
M. A AL-Mudhafar; M Nima Mezher; I. M Noaman. "The Association of Angiotensin-Converting Enzyme 2 Polymorphism and SARS-CoV-2 Infection in the Iraqi Population". سامانه مدیریت نشریات علمی, 78, 1, 1401, 9-14. doi: 10.22092/ari.2022.358871.2323
AL-Mudhafar, M. A, Nima Mezher, M, Noaman, I. M. (1401). 'The Association of Angiotensin-Converting Enzyme 2 Polymorphism and SARS-CoV-2 Infection in the Iraqi Population', سامانه مدیریت نشریات علمی, 78(1), pp. 9-14. doi: 10.22092/ari.2022.358871.2323
AL-Mudhafar, M. A, Nima Mezher, M, Noaman, I. M. The Association of Angiotensin-Converting Enzyme 2 Polymorphism and SARS-CoV-2 Infection in the Iraqi Population. سامانه مدیریت نشریات علمی, 1401; 78(1): 9-14. doi: 10.22092/ari.2022.358871.2323

The Association of Angiotensin-Converting Enzyme 2 Polymorphism and SARS-CoV-2 Infection in the Iraqi Population

Archives of Razi Institute
مقاله 4، دوره 78، شماره 1، فروردین و اردیبهشت 2023، صفحه 9-14    اصل مقاله (385.73 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358871.2323
نویسندگان
M. A AL-Mudhafar* 1؛ M Nima Mezher2؛ I. M Noaman3
1Department of Microbiology, Faculty of Veterinary Medicine, University of Kufa, Kufa, Iraq
2Department of Biology, Faculty of Science, University of Kufa, Kufa, Iraq
3Department of Physiology, Faculty of Veterinary Medicine, University of Kufa, Kufa, Iraq
چکیده
The quick and advancing prevalence of the new coronavirus SARS-CoV-2 produced a global crisis surge with a profound impact on human health and worldwide economic constancy. The virus is known as one strain of coronavirus, which causes the respiratory infection responsible for the current pandemic of COVID-19. The virus spike protein has a high binding affinity to human ACE2, depending on crystallization analysis and biochemical interaction studies. Studies consistently reveal that rs2285666, a polymorphism found in ACE2, diverse significantly between Europeans and Asians, changing ACE2 expression. The alternating allele TT of rs2285666 SNP increased gene expression to 50%; thus, it may have a role in SARS-COV-2 infection vulnerability. This study aimed to investigate rs2285666 SNP association with SARS-CoV2 infection as a first report in the Iraqi population. Fifty (20 Male/30 Female) Covid-19 patients with severe symptoms with mean age (of 41.5±10.7) and 50 (20 Male/30 Female) healthy people as a control group with mean age (of 41.5±10.7) were included in this study. Sample of a patient tested as a mutant genotype (TT) by RFLP assay. The results reveal a MAF value of 0.3 for this gene in Iraqi samples, more than Europeans (0.2) and less than East Asians (0.55). The codominant model had significant OR of both alleles CT and TT (OR=4.26 & 6.7; P-value=0.012 & 0.023 respectively). In conclusion, there is an association between increased severity of SARS-Cov-2 infection and rs2285666 polymorphism of the codominant genotype model of the Iraqi population. However, several other factors may affect disease severity, such as ethnic group differences, sex, comorbidity, virus strain, and others.
کلیدواژه‌ها
Angiotensin-Converting Enzyme 2؛ Polymorphism؛ SARS-CoV-2
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مراجع
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