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Haematological parameters in COVID-19 patients: association with severity of the disease | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 05 خرداد 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.358363.2208 | ||
| نویسندگان | ||
Anwar Ali. Abdulla  ؛ Thekra Abdulaali Abed؛ Eman Fadhel Abbas Awadh
| ||
| Department of Biology, College of Sciences, University of Babylon, Iraq. | ||
| چکیده | ||
| The new coronavirus (COVID-19) caused severe acute respiratory coronavirus syndrome (SARS-CoV-2; previously recognized as 2019-nCoV) and has symptoms that range from very mild to life-threatening. The aim of this study was to investigate at the different blood markers in confirmed positive COVID-19 individuals and see how they associated to the severity of the condition. A cross sectional study was conducted during the period from September 2020 to March 2021 on seventy-six (20 female and 56 male) Iraqi patients unvaccinated against COVID-19. The mean age of the study subjects ages was (47.00±13.31; 43.86±14.27) years for male and female respectively. There were 68.42% of the cases with mild illness, 14.47% with moderate illness and 17.10% were severely ill. The severity of COVID-19 was assessed by several hematological parameters, including white blood cell (WBC) count, derived indicators such as neutrophils to lymphocyte ratio (NLR) and IL6, C-reactive protein (CRP), D-dimer, and S-ferritin. The results showed lymphocyte count was lower in severely ill patients compared to patients with mild and moderate symptoms, with a significant difference between the three groups (2.274.83). Additionally, the NLR results showed a significant rise (11.56±1.23) in sever COVID-19. The results of present study indicated that serum level of IL6, CRP and S-ferritin revealed significant differences (41.20±6.23 pg/ml), (50.66±12.55 mg/l) and (454.60±95.69 ng/ml) at (P ≤ 0.05) in sever ill compared with mild and moderately ill patients respectively. The results indicated highly significant positive correlation between IL6 and severity of COVID-19 infection at P< 0. 01. Furthermore, a positive connection is seen in Neutrophil, CRP, and NLR (0.229, 0.264, and 0.277) at (P ≤ 0.05) respectively. | ||
| کلیدواژه‌ها | ||
| COVID-19؛ disease severity؛ hematological parameters؛ IL6؛ CRP | ||
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آمار تعداد مشاهده مقاله: 5 |
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