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| تعداد نشریات | 280 |
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Effects of Avena sativa and Glycyrrhiza glabra leaves extracts on immune responses in serum cytokine and liver enzyme levels in NIH mice | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 خرداد 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.357982.2128 | ||
| نویسندگان | ||
Haifa Nori Mater  ؛ Rand Manaf Abd Al-Rhman؛ Shaima R.Ibraheem؛ Marwa Shaker Mahmood
| ||
| Department of Biotechnology, College of Science, University of Baghdad, Baghdad, IRAQ | ||
| چکیده | ||
| Medicinal plants are well-known not just for their high concentrations of active ingredients, but also for their pharmacological properties, which include immune system regulation. Therefore, this study was aimed to investigate effects of Avena sativa and Glycyrrhiza glabra leaves extracts on immuneresponses in serum cytokine and liver enzyme degrees. The phytochemical screening of crude leaf extracts from Avena sativa found out that: alkaloids, flavonoids, tannins, phenolic and saponins had been present in ethanolic extract, while resines and violet oils had been absent. On the other hand violet oils, flavonoids, tannins, saponins and glycosides presented at a high level in Glycyrrhiza glabra ethanolic extract, while resins and phenolic compound were not found in Glycyrrhiza glabra ethanolic extract. 50 healthy male NIH mice were randomly divided into 5 groups as follows: Except for control group all the animals were pre-treated with extracts (50 mg/kg) subcutaneously and orally for 14 days before the LPS-induced (1 mg/kg body weight) damage liver. On day 15 (14 days after extracts administration), liver damage was induced by LPS and the mice then fasted. Group 1: control group injected subcutaneously with normal saline. Group 2: injected subcutaneously with 100 μl of crude Oat extract. Group 3: orally received 100 μl (50 mg/kg) of crude Oat extract. Group 4: injected subcutaneously with 100 μl (50 mg/kg) of crude Licorice extract. Group 5: orally received 100 μl (50 mg/kg) of crude Licorice extract. The level of IL-4 showed significant elevation (P≥ 0.05) in subcutaneous and orally treated groups (75.6 ± 2.8 and 83.3 ± 1.7; 61.0 ± 0.4 and55.8 ± 2.8) pg/ml for Avena sativa and Glycyrrhiza glabra extracted respectively as compared with control (12.3 ± 0.23) pg/ml. The amount of IL-6 showed significant elevation (P≥0.05) in subcutaneous and orally treated mice (128.5 ± 4.6 and135.6 ± 2.7; 119.6 ± 5.1 and115.2 ± 1.9) pg/ml for Avena sativa and Glycyrrhiza glabra extracted respectively compared with control (44 ± 0.57) pg/ml. | ||
| کلیدواژه‌ها | ||
| Glycyrrhiza glabra؛ Liver features (GOT and GPT)؛ Interleukins؛ mice | ||
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آمار تعداد مشاهده مقاله: 106 |
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