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Hashim, Z. R, Qasim, Q. A, ALabbood, M. H. (1401). The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 77(5), 1593-1600. doi: 10.22092/ari.2022.357641.2081
Z. R Hashim; Q. A Qasim; M. H ALabbood. "The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1593-1600. doi: 10.22092/ari.2022.357641.2081
Hashim, Z. R, Qasim, Q. A, ALabbood, M. H. (1401). 'The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes', سامانه مدیریت نشریات علمی, 77(5), pp. 1593-1600. doi: 10.22092/ari.2022.357641.2081
Hashim, Z. R, Qasim, Q. A, ALabbood, M. H. The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes. سامانه مدیریت نشریات علمی, 1401; 77(5): 1593-1600. doi: 10.22092/ari.2022.357641.2081

The Association of Serum Calcium and Vitamin D with Insulin Resistance and Beta-Cell Dysfunction among People with Type 2 Diabetes

Archives of Razi Institute
مقاله 11، دوره 77، شماره 5، آذر و دی 2022، صفحه 1593-1600    اصل مقاله (524.67 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357641.2081
نویسندگان
Z. R Hashim* 1؛ Q. A Qasim1، 2؛ M. H ALabbood3
1Clinical Laboratory Sciences Department, College of Pharmacy, University of Basra, Basra, Iraq
2College of Pharmacy, Al-Ayen University, Thi-Qar, Iraq
3Alzahraa College of Medicine, University of Basra, Basra, Iraq
چکیده
Cross-sectional studies have linked vitamin D deficiency and alteration of calcium levels to an increased incidence of type 2 diabetes and insulin resistance. This study investigated a possible correlation between blood vitamin D and calcium levels with insulin resistance and beta-cell dysfunction in type 2 diabetes, pre-diabetes, and healthy individuals. This cross-sectional study involved 300 participants. Participants were divided into three groups (n=100), type 2diabetic, prediabetic, and healthy. In order to measure insulin resistance and β –cell function, the HOMA IR and HOMA B were assessed, respectively. Also, the other parameters such as serum 25(OH)D, blood insulin (FPI), glucose (FBS), HbA1c, and calcium were assessed in this study. In simple regression analysis, a high vitamin D level is linked to lower levels of FBS, HbA1c, Insulin, and HOMA IR, and higher levels of HOMA B. Calcium has a positive connection with FBS and HbA1c and a negative connection with insulin level and HOMAB. Hypovitaminosis D may substantially influence diabetes patients' glycemic dysregulation. "An increased incidence of type 2 diabetes has been related to a disruption in calcium homeostasis. All in all an increament in calcium levels may have a role in developing type 2 diabetes".
کلیدواژه‌ها
Type 2M؛ 25 (OH) D؛ Calcium؛ Vitamin D deficiency؛ Insulin resistance؛ Glycemic control
مراجع
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