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Chauke, Alinah, Shai, Leshweni, Mogale, Motatelo. (1401). Plants Today Drugs Tomorrow: Cordia Grandicalyx A Possible Future Anti-Hypoglycaemic?. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/jmpb.2022.356394.1415
Alinah Mildred Chauke; Leshweni Jeremiah Shai; Motatelo Alfred Mogale. "Plants Today Drugs Tomorrow: Cordia Grandicalyx A Possible Future Anti-Hypoglycaemic?". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/jmpb.2022.356394.1415
Chauke, Alinah, Shai, Leshweni, Mogale, Motatelo. (1401). 'Plants Today Drugs Tomorrow: Cordia Grandicalyx A Possible Future Anti-Hypoglycaemic?', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/jmpb.2022.356394.1415
Chauke, Alinah, Shai, Leshweni, Mogale, Motatelo. Plants Today Drugs Tomorrow: Cordia Grandicalyx A Possible Future Anti-Hypoglycaemic?. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/jmpb.2022.356394.1415

Plants Today Drugs Tomorrow: Cordia Grandicalyx A Possible Future Anti-Hypoglycaemic?

Journal of Medicinal plants and By-product
مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 26 اردیبهشت 1401    اصل مقاله (1.42 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/jmpb.2022.356394.1415
نویسندگان
Alinah Mildred Chauke* 1؛ Leshweni Jeremiah Shai1؛ Motatelo Alfred Mogale2
1Department of Biomedical Sciences, Tshwane University of Technology, Private Bag X680, Pretoria, South Africa
2Department of Biochemistry, Sefako Makgatho Health Science University, Medunsa, South Africa
چکیده
Lowering blood glucose levels by enhancing glucose uptake and GLUT4 translocation is an important strategy in glucose homeostasis in insulin-sensitive tissues. Similarly, traditional medicinal plants are used by several traditional healers, and plants are a possible avenue for the discovery and development of antidiabetic drugs. The study aimed to investigate the effects of Cordia grandicalyx bark, fruit, and leaf extracts through glucose uptake activity by preadipocytes, liver and skeletal muscle cells, relative to their capability on increasing GLUT4 translocation. In addition, the protein expression and phosphorylation of diabetes-related proteins were performed. The C. grandicalyx extracts increased glucose uptake activity by enhancing GLUT4 translocation. Moreover, it was established that the co-usage of insulin with plant extracts increased the glucose uptake activity in comparison to insulin. The extracts upregulated total insulin receptor substrate expression and increased the phosphorylation of Akt levels. This data, therefore, suggests that C. grandicalyx enhances glucose uptake by modulating insulin signalling, potentially through GLUT4 translocation and upregulation of diabetes-related proteins, possibly mimicking the PI3-K/Akt pathway. This, therefore, suggests that C. grandicalyx is a possible candidate for the management of diabetes.
کلیدواژه‌ها
Medicinal plants؛ Diabetes mellitus؛ Insulin signals؛ C. grandicalyx
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