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Rifaat Muhammad, Hiwa, Obaid Othman, Galawezh. (1401). Molecular Study of ACE2 Gene Polymorphism of COVID-19 Infection Among the Kurdish Population in Kurdistan Region- Iraq. سامانه مدیریت نشریات علمی, (), -. doi: 10.22092/ari.2022.358492.2232
Hiwa Rifaat Muhammad; Galawezh Obaid Othman. "Molecular Study of ACE2 Gene Polymorphism of COVID-19 Infection Among the Kurdish Population in Kurdistan Region- Iraq". سامانه مدیریت نشریات علمی, , , 1401, -. doi: 10.22092/ari.2022.358492.2232
Rifaat Muhammad, Hiwa, Obaid Othman, Galawezh. (1401). 'Molecular Study of ACE2 Gene Polymorphism of COVID-19 Infection Among the Kurdish Population in Kurdistan Region- Iraq', سامانه مدیریت نشریات علمی, (), pp. -. doi: 10.22092/ari.2022.358492.2232
Rifaat Muhammad, Hiwa, Obaid Othman, Galawezh. Molecular Study of ACE2 Gene Polymorphism of COVID-19 Infection Among the Kurdish Population in Kurdistan Region- Iraq. سامانه مدیریت نشریات علمی, 1401; (): -. doi: 10.22092/ari.2022.358492.2232

Molecular Study of ACE2 Gene Polymorphism of COVID-19 Infection Among the Kurdish Population in Kurdistan Region- Iraq

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مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 17 اردیبهشت 1401  XML
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358492.2232
نویسندگان
Hiwa Rifaat Muhammad email 1؛ Galawezh Obaid Othman2
1Biology Department, College of Education, Salahaddin University-Erbil, Iraq
21,2Biology Department, College of Education, Salahaddin University-Erbil, Iraq
چکیده
Coronavirus Disease 2019 (COVID-19) is a current pandemic infection of human respiratory system, which is caused by which caused by Sever Acute respiratory syndrome virus 2 (SARS-CoV-2). The infection was classified by World Health Organization (WHO) as a universal pandemic in February 2020, there have been 494.587.638 confirmed cases and 6.170.283 deaths. The present study was conducted to investigate molecular genetics of Angiotensin Converting Enzyme 2 (ACE2) gene in correlation to COVID-19 patients in Kurdish population. Eighty-six individuals clinically diagnosis with COVID-19 and control groups. After the genomic DNA extraction these participants the target 1,2, and 8 exons of the ACE2 gene were amplified using PCR technique, then Sanger sequencing technique was performed to analyze genetic variants of ACE2 gene in 70 DNA samples of COVID-19 hospital patients at Emergency Hospital in Erbil city, Sarchnar Hospital in Sulaymaniyah city, Lalav Hospital in Duhok city and Wafa Hospital in Halabja city from Kurdistan Region of Iraq. The current study was designed in to two groups control group and patient group. The patient group was divided in to two sub groups severe and mild patients in different ages and genders. As a result, there was no any mutations at the positions 1, 2 and 8 exons sequences, while single nucleotide polymorphisms (SNPs) were detected and identified three different types mutation at intron position: twenty-six of c.12405 del T, two of c.12407 T>G, and two of c.12406 G>A in a total 86 participants. This result show that genetic difference does not impact on the COVID-19 infection severity among the Kurdish population regarding to ACE2 gene polymorphism.
کلیدواژه‌ها
COVID-19؛ ACE2 gene؛ SNP of ACE2 gene and X chromosome
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تعداد مشاهده مقاله: 25


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