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Serological findings and expression of IL-1βand IL-6 genes in patients infected with Mycobacterium Tuberculosis in Iraq | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 10 اردیبهشت 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.357620.2073 | ||
| نویسندگان | ||
Yousor Majid Jameel  ؛ Zena Kassem Khalil
| ||
| Department of Optometry, Medical-Technical Institute, Almansour Middle Technical University, Iraq (MTU) | ||
| چکیده | ||
| Mycobacterium Tuberculosis (TB) is one of the serious bacterial infections that cause diseases and may lead to death. In this study, 178 individuals were examined for TB infection at Baghdad TB center during the period from 15th January to 1st October 2021. Out of 178 participants 73 were shown to be positive for TB infection, while 105 showed negative results. According to the results, there was no significant variation between infected males and females with TB in comparison with the control group (P>0.05). The results showed that the mean age of patients for both males and females were in a range of 2–65 years. Also there were significant differences in patients with TB compared to the control group in terms of weight loss 8.82 ± 6.75 Kg, RBC count (3.43 ± 0.56) × 106/μl, WBC count (3.12 ± 1.57) × 106/μl, Platelet count (1.03 ± 0.56) × 106/μl and Hemoglobin level(6.66 ± 1.34) g/dl. A total of 30 TB patients and 50 normal individuals were genotyped to detect the IL-1β rs 114534gene. PCR was used for exone amplification in region 5 of ILB1 gene in the TB patients by using specific primers. The finding showed that there was an amplified product of 249bp located in chromosome 2q13-14.A total of 30 TB patients and 50 normal individuals were also genotyped to detect the IL-6 rs 1800795 gene. PCR was used for amplification of IL-6 gene in TB patients by using specific primers. The finding showed that there was an amplified product of 431 bp located in chromosome 7p15-p2. Expression of ILB1 gene was investigated in TB patients and healthy controls by using qPT-PCR. Results showed that there was a high Ct value for patients and controls with a high Ct value of templates, preoperational to the total RNA concentration and gene expression. Expression of IL-6 gene was investigated in TB patients and healthy controls by using qPT-PCR. Results showed that there was a high Ct value for patients and controls with a high Ct value of templates, preoperational to the total RNA concentration and gene expression. | ||
| کلیدواژه‌ها | ||
| IL-1&beta؛ , IL-6 genes, MycobacteriumTuberculosis | ||
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آمار تعداد مشاهده مقاله: 5 |
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