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Hepatic Impact for Different Concentrations of hibiscus rosa zinc oxide Nanoparticles in Rats | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 01 اردیبهشت 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.357530.2060 | ||
| نویسنده | ||
Zainab Sattar Ali 
| ||
| Dept. of Pharmacology and Toxicology, College of Pharmacy, University of Al-Muthana, Iraq | ||
| چکیده | ||
| Nanomaterial, especially zincoxid nanoparticles, has entered the manufacture of many materials that use in daily lives. A Current study was designed to evaluate the impact of three concentrations of hibiscus rosa zinc oxide nanoparticles (HrZnONPs) and hibiscus rosa extract (Hre) on the liver tissue and DNA fragmentation of liver cell. Thirty five adult male Wistar rats were grouped as follows; First group is control (𝑁=7); it was not received any treatment. The remaining twenty eight animals were distributed randomly into four groups. The group 1 (𝑁=7) injected subcutaneously with 100mgkg BW of Hibiscus rosa extract for 60 days; group 2 rats injected subcutaneously with 25 mgkg BW of HrZnONPs for 60 days; group 3 rats injected subcutaneously with 75mgkg BW of HrZnONPs for 60 days; group 4 were injected subcutaneously with 100mgkg BW of HrZnONPs for 60 days. The liver biomarkers, aspartate aminotransferase (AST), alkaline phosphatase (ALP) and alanine aminotransferase (ALT) have been assessed in serum at zero time, after one month and after two months of experiment. At the end f the experiment all the animals were euthanized and then the liver was dissected and specimen undergone the pathohistological investigation and the percentage DNA fragmentation was evaluated. The results showed that the rats that had remediated with HrZnONPs at concentrations of 75 and 100 mgkg B.W. registered salient elevation in activities values for AST, ALP and ALT, modulation in hepatic tissue architecture, elevated percentage of high DNA damage compared to those remediated with HrZnONPs in concentration of 25 mgkg B.W. On the other hand the recorded data showed that the administration of Hre has some ameliorative effects on AST, ALP and ALT levels, beterment in histology cross section and value of comet assay for liver cells due to the Hre antioxidant role. In conclusion, the results of the current study demonstrated the high dose of HrZnONPs has more adverse impact compared to the low dose and confirmed the ameliorative impact of Hre on liver biomarkers, histology cross section of liver and DNA damage. | ||
| کلیدواژه‌ها | ||
| Hibiscus rosa (Hibiscus rosa-sinensis)؛ Zinc oxide nanoparticles؛ Liver biomarkers؛ genotoxic؛ Hepatotoxicity | ||
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آمار تعداد مشاهده مقاله: 38 |
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