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آمار
| تعداد نشریات | 280 |
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Comparative genetic features of complete spike1 gene of six Massachusetts (Mass) and variant 2 infectious bronchitis viruses isolated from chicken flocks in Iran | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 فروردین 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.356836.1924 | ||
| نویسندگان | ||
najmeh Motamed   1؛ Mohsen Bashashati2
| ||
| 1Razi Vaccine and Serum Research Institute | ||
| 2Department of Avian Disease Research and Diagnostic, Razi Vaccine and Serum Research Institute, Agricultural Research Education and Extension Organization (AREEO), Karaj, Iran | ||
| چکیده | ||
| One of the leading causes of respiratory disease problems in chicken and economic loss in poultry industry even in developed countries with good biosecurity practices is infectious bronchitis (IB) disease. Since first isolation of the virus in 1931, a lot of serotype and genotypes of the virus have been reporting around the world. GI-1 lineage including Massachusetts serotype viruses is one of the most distributed types all over the world. GI-23 lineage was reported approximately 20years ago from Middle East with increasing incidence but no or little homologues vaccine use, until recently the genotype was restricted to this region but there is some evidence of its spread to the European countries rising concerns of emerging outbreaks. In the present study we tried to analyzed S1 gene of six Massachusetts and Variant2 genotypes phylogenically which were isolated from broiler and broiler breeder flocks in Iran. Variant 2 viruses were clustered with other reported variant 2 viruses in neighboring countries with more than 98% identity with last Iranian reported variant2 and 3 Mass type viruses were close to Mass type and vaccine viruses, emphasizing circulation of vaccine derived viruses in the field which increases risk of mutation and recombination with field isolates following the emergence of new variants that may not have cross protection with vaccine strains immunity. Considering variable nature of IBVs which few changes lead to important differences, continuous epidemiological surveillances with clinical experiments and full genome evaluation of new isolates are crucial to better understand of their pathogenicity thereafter control of the disease. | ||
| کلیدواژه‌ها | ||
| Spike glycoprotein؛ phylogenetic analysis؛ Middle east؛ lineage | ||
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آمار تعداد مشاهده مقاله: 7 |
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