- همه نشریات
- نشریات علمی سازمان تحقیقات، آموزش و ترویچ کشاورزی
- مجلات ترویجی سازمان تحقیقات، آموزش و ترویج کشاورزی
- سایر نشریات سازمان تحقیقات، آموزش و ترویج کشاورزی
- نشریات علمی انجمن ها
- علوم آب و خاک
- علوم اقتصاد و ترویج کشاورزی
- علوم جنگل, مرتع و آبخیزداری
- علوم دامی و شیلات
- علوم زراعی و باغی
- علوم گیاهپزشکی
- علوم مهندسی و مکانیزاسیون کشاورزی
- نشریات با زبان انگلیسی
- نشریات با زبان فارسی
- نشریات دانشگاه آزاد اسلامی
- نشریات علمی
آمار
| تعداد نشریات | 280 |
| تعداد نشریات سازمان | 79 |
| تعداد شماره‌ها | 2,319 |
| تعداد مقالات | 26,819 |
| تعداد مشاهده مقاله | 14,728,940 |
| تعداد دریافت فایل اصل مقاله | 11,782,679 |
Influence of Serum Level of Human Epididymis Protein 4 (HE4) and Interlukin-6(IL-6) as Biomarkers in Patients with Adnexal Mass | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 27 فروردین 1401 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2022.358329.2194 | ||
| نویسندگان | ||
Safa Hameed  1؛ Hanadi Abdulqader Jasim2؛ Maysoon Sharief3
| ||
| 1Department of Microbiology, College of Medicine, University of Basrah, Iraq | ||
| 21Department of Microbiology, College of Medicine, University of Basrah, Iraq, | ||
| 32Department of Gynecology and Obstetrics, College of Medicine, University of Basrah, Iraq, Orcid ID: 0000-0002-2900-1811. | ||
| چکیده | ||
| Ovarian carcinoma is one of the most common types of neoplasms in women and the fifth leading cause of cancer death in among women worldwide. Adnexal masses are classified as simple or complicated and can be benign or malignant. There is no single biomarker has demonstrated high sensitivity and specificity for detecting early Ovarian Cancer. Therefore current study was designed to investigate the influence of using two biomarkers as a tool of diagnosis in patients with Adnexal mass. A prospective case control study was carried out on 50 women, their age ranged from 16 years - 80 years old, who had been attended the surgical room of Basrah Hospitals, through the period from January till July 2021. Fifty patients diagnosed by Ultrasound and MRI with Adnexal masses and scheduled for surgery and from 50 healthy women as a control group. The serum biomarkers levels were quantitatively assessed by using ELISA. The serum concentration of HE4 biomarker exhibited significant differences between women with Adnexal mass and healthy women. There is no significant association neither for the patient’s age nor the menopausal state with serum level of HE4 that had a sensitivity of 92% % and a specificity of 66 % as a serum marker for the presence of Adnexal mass with PPV of 73 % and NPV of 89%. In this study, serum IL6 has a sensitivity of 30% and specificity of 64% in determining patients with Adnexal mass pathology. It was found that the level of IL-6 was similar in all patients as compared to their level at the control group.The median levels of serum HE4 showed high value in patients with age groups (21-40), (41-50) and >50) than in control group but without any statistical difference (P value = 0.413). Human epididymis protein 4 (HE4), was the top biomarker representing a higher concentration in Adnexal mass also it demonstrated the highest performance in all samples with Adnexal mass. Our study found that combining more than one marker measurement increased the sensitivity and the specificity of distinguishing patients with Adnexal mass pathology. | ||
| کلیدواژه‌ها | ||
| Adnexal mass؛ HE4؛ IL-6؛ Ovarian cancer | ||
|
آمار تعداد مشاهده مقاله: 23 |
||
