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SH, R. (1401). Study of Microbial Infections and Some Immunological Parameters among Covid-19 in ICU Patients in Najaf Governorate, Iraq. سامانه مدیریت نشریات علمی, 77(5), 1569-1574. doi: 10.22092/ari.2022.358102.2151
R SH. "Study of Microbial Infections and Some Immunological Parameters among Covid-19 in ICU Patients in Najaf Governorate, Iraq". سامانه مدیریت نشریات علمی, 77, 5, 1401, 1569-1574. doi: 10.22092/ari.2022.358102.2151
SH, R. (1401). 'Study of Microbial Infections and Some Immunological Parameters among Covid-19 in ICU Patients in Najaf Governorate, Iraq', سامانه مدیریت نشریات علمی, 77(5), pp. 1569-1574. doi: 10.22092/ari.2022.358102.2151
SH, R. Study of Microbial Infections and Some Immunological Parameters among Covid-19 in ICU Patients in Najaf Governorate, Iraq. سامانه مدیریت نشریات علمی, 1401; 77(5): 1569-1574. doi: 10.22092/ari.2022.358102.2151

Study of Microbial Infections and Some Immunological Parameters among Covid-19 in ICU Patients in Najaf Governorate, Iraq

Archives of Razi Institute
مقاله 8، دوره 77، شماره 5، آذر و دی 2022، صفحه 1569-1574    اصل مقاله (480.32 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.358102.2151
نویسنده
R SH*
Laboratory Investigation, Science College, Kufa University, Kufa, Iraq
چکیده
The present study aimed to investigate some microbial infections and immunological parameters associated with Covid-19 patients admitted to the intensive care unit (ICU) of Al-Amal Specialized Hospital in AL-Najaf Governorate during February and March 2021. The study included 50 patients who were assigned to two groups: 20 patients aged ≤70 years and 30 patients aged ≥70 years. The method of microbial culture was adopted to isolate bacteria and yeasts by collecting sputum specimens and oral swabs from patients and cultivating them on diagnostic media and then confirming the diagnosis by Vitek. Moreover, serum samples were collected from patients’ blood to diagnose fungal infections. Thereafter, some immunological criteria were assessed, including Covid-19 diagnosis by measuring Immunoglobulin M (IgM) and IgG, as well as examining the concentration of cytokines (Interleukin 6 (IL-6) and IF ) using the enzyme-linked immunosorbent assay (ELISA) method. The results demonstrated that bacterial species Streptococcus pneumonia (n=5; 25%), Haemophilus Influenzae (n=7; 35%), and Moraxella catarrhalis (n=3; 15%) were isolated from the first group of patients (≤70 years). The recorded data pointed out that Streptococcus pneumonia (n=10; 33.3%), Streptococcus pyogenes (n=5; 16.6%), Streptococcus viridans (n=1; 3.3%), Haemophilus Influenzae (n=6; 20%), Mycobacterium tuberculosis (n=2; 6.6%), and Pseudomonas aeruginosa (n=2; 6.6%) were the isolated and identified microorganisms in the second age group (≥ 70 years). The results revealed that the isolated yeast from the first age group was Candida albicans (n=5; 25%) and Candida glabrata (n=3; 10%), while in the second age group, 1 (3.3%) Candida albicans was isolated. The results of this study proved that 30% and 10% of patients in the first and second age groups had invasive pulmonary aspergillosis co-infection by detecting Galactomannan (GM) in the blood serum (1.05±0.59, 1.25±0.38), respectively. The results indicated that IgM and IgG levels in the serum of patients in the first age group were 11.42±6.82 and 0.47±6.82, respectively. Moreover, the levels of IgM and IgG in the second age group were 14.84±9.21 and 0.12±0.11, respectively. Furthermore, IFɤ and IL6 levels were 98.37±65.70, and 146.12±46.35 in the first group, while IFɤ and IL6 were obtained at 110.69±47.60 and 133.28±116.94 in the second group, respectively. Elderly patients with severe COVID-19 are more frequently admitted to ICUs since the proportion of severe cases and comorbidities caused by a weakened immune system is higher among this age group. Secondary bacterial infections can also occur, especially Gram-negative bacteria which are among the most significant public health problems worldwide. Moroever, aspergillosis may infect patients hospitalized with COVID-19 and lead to death.
کلیدواژه‌ها
Covid-19؛ ICU؛ IFɤ؛ IgG؛ IgM؛ IL-6؛ IPA
مراجع
  1. Purdy AC, De Virgilio C, Kaji AH, Frey ES, Lee-Kong S, Inaba K, et al. Factors associated with general surgery residents’ operative experience during the COVID-19 pandemic. JAMA Surg. 2021;156(8):767-74.
  2. Monteiro WM, Brito-Sousa JD, Baía-da-Silva D, Melo GCd, Siqueira AM, Val F, et al. Driving forces for COVID-19 clinical trials using chloroquine: the need to choose the right research questions and outcomes. Rev Soc Bras Med Trop. 2020;53.
  1. Malik P, Patel U, Mehta D, Patel N, Kelkar R, Akrmah M, et al. Biomarkers and outcomes of COVID-19 hospitalisations: systematic review and meta-analysis. BMJ Evid-Based Med. 2021;26(3):107-8.
  2. Phua J, Weng L, Ling L, Egi M, Lim C-M, Divatia JV, et al. Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations. Lancet Respir Med. 2020;8(5):506-17.
  3. Baskaran V, Lawrence H, Lansbury LE, Webb K, Safavi S, Zainuddin NI, et al. Co-infection in critically ill patients with COVID-19: an observational cohort study from England. J Med Microbiol. 2021;70(4).
  4. Nasa P, Singh A, Upadhyay S, Bagadia S, Polumuru S, Shrivastava PK, et al. Tocilizumab use in COVID-19 Cytokine-release syndrome: retrospective study of two centers. Indian J Crit Care Med. 2020;24(9):771.
  5. Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, et al. Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Arch Clin Infect Dis. 2020;71(15):762-8.
  6. Dres M, Hajage D, Lebbah S, Kimmoun A, Pham T, Béduneau G, et al. Characteristics, management, and prognosis of elderly patients with COVID-19 admitted in the ICU during the first wave: insights from the COVID-ICU study. Ann Intensive Care. 2021;11(1):1-11.
  7. Gkoufa A, Maneta E, Ntoumas GN, Georgakopoulou VE, Mantelou A, Kokkoris S, et al. Elderly adults with COVID-19 admitted to intensive care unit: A narrative review. World J Crit Care Med. 2021;10(5):278.
  8. Fu Y, Yang Q, Xu M, Kong H, Chen H, Fu Y, et al., editors. Secondary bacterial infections in critical ill patients of COVID-19. Open forum infectious diseases; 2020.
  9. Zhang H, Zhang Y, Wu J, Li Y, Zhou X, Li X, et al. Risks and features of secondary infections in severe and critical ill COVID-19 patients. Emerg Microbes Infect. 2020;9(1):1958-64.
  10. Bag Soytas R, Cengiz M, Islamoglu MS, Uysal BB, Ikitimur H, Yavuzer H, et al. Does the COVID‐19 seroconversion in older adults resemble the young? J Med Virol. 2021;93(10):5777-82.
  11. Luporini RL, Joice MdA, Kubota LT, Martin ACBM, Cominetti MR, de Freitas Anibal F, et al. IL-6 and IL-10 are associated with disease severity and higher comorbidity in adults with COVID-19. Cytokine. 2021;143:155507.
  1. Marta G-C, Lorena F-E, Laura M-V, Angela L-M, Blanca L-G, Rodrigo A-A, et al. COVID-19-Associated Pulmonary Aspergillosis in a Tertiary Hospital. J Fungi. 2022;8(2):97.
  2. Hainz U, Jenewein B, Asch E, Pfeiffer K-P, Berger P, Grubeck-Loebenstein B. Insufficient protection for healthy elderly adults by tetanus and TBE vaccines. Vaccine. 2005;23(25):3232-5.
  3. Feldman C, Anderson R. The role of co-infections and secondary infections in patients with COVID-19. Pneumonia. 2021;13(1):1-15.
  4. Bengoechea JA, Bamford CG. SARS‐CoV‐2, bacterial co‐infections, and AMR: the deadly trio in COVID‐19? EMBO Mol Med. 2020;12(7):12560.
  1. Hendaus MA, Jomha FA, Alhammadi AH. Virus-induced secondary bacterial infection: a concise review. Ther Clin Risk Manag. 2015;11:1265.
  2. Chen G, Wu D, Guo W, Cao Y, Huang D, Wang H, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Investig. 2020;130(5):2620-9.
  3. Manohar P, Loh B, Athira S, Nachimuthu R, Hua X, Welburn SC, et al. Secondary bacterial infections during pulmonary viral disease: phage therapeutics as alternatives to antibiotics? Front Microbiol. 2020;11:1434.
  4. Pasrija R, Naime M. The deregulated immune reaction and cytokines release storm (CRS) in COVID-19 disease. Int Immunopharmacol. 2021;90:107225.
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