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Gasmi, A, Noor, S, Piscopo, S, Menzel, A. (1401). Toxic Metal –Mediated Neurodegradation: A Focus on Glutathione and GST Gene Variants. سامانه مدیریت نشریات علمی, 77(2), 525-536. doi: 10.22092/ari.2021.356279.1816
A Gasmi; S Noor; S Piscopo; A Menzel. "Toxic Metal –Mediated Neurodegradation: A Focus on Glutathione and GST Gene Variants". سامانه مدیریت نشریات علمی, 77, 2, 1401, 525-536. doi: 10.22092/ari.2021.356279.1816
Gasmi, A, Noor, S, Piscopo, S, Menzel, A. (1401). 'Toxic Metal –Mediated Neurodegradation: A Focus on Glutathione and GST Gene Variants', سامانه مدیریت نشریات علمی, 77(2), pp. 525-536. doi: 10.22092/ari.2021.356279.1816
Gasmi, A, Noor, S, Piscopo, S, Menzel, A. Toxic Metal –Mediated Neurodegradation: A Focus on Glutathione and GST Gene Variants. سامانه مدیریت نشریات علمی, 1401; 77(2): 525-536. doi: 10.22092/ari.2021.356279.1816

Toxic Metal –Mediated Neurodegradation: A Focus on Glutathione and GST Gene Variants

Archives of Razi Institute
مقاله 3، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 525-536    اصل مقاله (527.3 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22092/ari.2021.356279.1816
نویسندگان
A Gasmi* 1؛ S Noor2؛ S Piscopo1، 3؛ A Menzel4
1Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
2Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, Pakistan
3Research and Development Department, Nutri-Logics SA, Weiswampach, Luxembourg
4Laboratoires Réunis, Junglinster, Luxembourg
چکیده
Increasing pieces of evidence have supported those chemicals from industrial, agricultural wastes and organoleptic activities play important role in the development of neurological disorders. The frequency of neurological disorders is increased to a much extent in recent years with the advancements in science and technology. Google Scholar, PubMed, and Scopus databases were selected to search the relevant information by using keywords including “Heavy metals”, “Neurotoxicity”, “Glutathione”, “Glutathione AND Neurodegenerative disorders” etc. Heavy metals are particularly recognized as a major resource of toxicities during the stage of early pregnancy where a fetus gets exposed to them from maternal activities and circulation. As infants have a weak immune system and cannot respond to the specific challenge as faced by the body during mercury, zinc, iron, and cadmium exposure. Daily diet and drinking habits in addition to industrial activities also form a major field of study under investigation. This study aims to investigate the role of these metals in the accumulation of pollutants in the brain, liver, and kidneys hence leading to serious consequences. Moreover, their prevalence in teenagers that are under the age of ten years is being observed that leads them to learn, writing, and intellectual abilities. Males are more affected due to their hormonal differences. The role of the GST gene in the development of cognitive conditions and its phenotypes has been discussed thoroughly in this review. The mutations of GST lead to the accumulation of peroxides and superoxides which exacerbate oxidative damage to cells. Binding of toxic metals to GSH genes and the role of glutathione transferase genes is was demonstrated in this review.
کلیدواژه‌ها
GSH (glutathione)؛ GST (glutathione s-transferase)؛ toxic metals؛ cognitive disease؛ neurodegenerative diseases
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