اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,050
تعداد مقالات34,082
تعداد مشاهده مقاله46,549,645
تعداد دریافت فایل اصل مقاله77,602,623
Gupta, S, Mujawdiya, P, Maheshwari, G, Sagar, S. (1401). Dynamic Role of Oxygen in Wound Healing: A Microbial, Immunological, and Biochemical Perspective. سامانه مدیریت نشریات علمی, 77(2), 513-523. doi: 10.22092/ari.2022.357230.2003
S Gupta; P Mujawdiya; G Maheshwari; S Sagar. "Dynamic Role of Oxygen in Wound Healing: A Microbial, Immunological, and Biochemical Perspective". سامانه مدیریت نشریات علمی, 77, 2, 1401, 513-523. doi: 10.22092/ari.2022.357230.2003
Gupta, S, Mujawdiya, P, Maheshwari, G, Sagar, S. (1401). 'Dynamic Role of Oxygen in Wound Healing: A Microbial, Immunological, and Biochemical Perspective', سامانه مدیریت نشریات علمی, 77(2), pp. 513-523. doi: 10.22092/ari.2022.357230.2003
Gupta, S, Mujawdiya, P, Maheshwari, G, Sagar, S. Dynamic Role of Oxygen in Wound Healing: A Microbial, Immunological, and Biochemical Perspective. سامانه مدیریت نشریات علمی, 1401; 77(2): 513-523. doi: 10.22092/ari.2022.357230.2003

Dynamic Role of Oxygen in Wound Healing: A Microbial, Immunological, and Biochemical Perspective

Archives of Razi Institute
مقاله 2، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 513-523    اصل مقاله (457.08 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22092/ari.2022.357230.2003
نویسندگان
S Gupta* 1؛ P Mujawdiya1؛ G Maheshwari1؛ S Sagar2
1Inochi Care Private Limited, C-10 (Basement), Malviya Nagar, New Delhi, India
2Department of Surgery, JPN Apex Trauma Center, All India Institute of Medical Sciences, New Delhi, India
چکیده
A wound is a temporary break in the continuity of the protective skin barrier. Wound healing is central in maintaining the body’s normal homeostatic mechanism, and open wounds raise the risk of microbial infection and amputation. A successful wound healing event is achieved through a series of evolutionarily conserved biochemical pathways orchestrated by various cytokines, growth factors, and immune cells. Chronic wounds are generally oxygen-deficient, and wound hypoxia impairs the wound healing process. Therefore, the use of external oxygen may improve wound health by reducing wound hypoxia, promoting tissue regeneration and granulation tissue formation, reducing anaerobic bacteria colonization, and promoting the growth of beneficial aerobic bacteria. Relevant data were searched and gathered from scientific databases, including PubMed, ScienceDirect, and Google Scholar using relevant keywords, such as “Chronic Wounds”,  “Topical Oxygen Therapy”, “Inflammatory Markers/ Lactate/ Matrix Metalloproteinase”, “Collagen”, and “Wound Healing”. Relevant articles were shortlisted and used in the present study. Chronic wounds show higher expression of pro-inflammatory mediators, such as C-reactive protein, and higher levels of tissue-degrading matrix metalloproteinases. In addition, chronic wounds are generally oxygen-deficient, and wound hypoxia is directly associated with wound deterioration. Several microbial, immunological, and biochemical markers show a direct association with the oxygen availability in the wound. Therefore, a detailed understanding of these microbial, immunological, and biochemical markers will certainly help clinicians understand the interplay between various factors and topical oxygen therapy and may improve patient outcomes.
کلیدواژه‌ها
Topical oxygen therapy؛ Chronic wounds؛ Wound hypoxia؛ Wound healing markers؛ Skin microflora
سایر فایل های مرتبط با مقاله
مراجع
  1. Kapp S, Santamaria N. The financial and quality-of-life cost to patients living with a chronic wound in the community. Int Wound J. 2017;14(6):1108-19.
  2. Maheshwari G, Gupta S, Tripathi S, Sagar S, kisaka t. Chronic wounds -Magnitude, Socioeconomic Burden and Consequences. 2021.
  3. Martin P, Nunan R. Cellular and molecular mechanisms of repair in acute and chronic wound healing. Br J Dermatol. 2015;173(2):370-8.
  4. Las Heras K, Igartua M, Santos-Vizcaino E, Hernandez RM. Chronic wounds: Current status, available strategies and emerging therapeutic solutions. J Control Release. 2020;328:532-50.
  1. Bowler PG, Duerden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev. 2001;14(2):244-69.
  2. Ridiandries A, Tan JTM, Bursill CA. The Role of Chemokines in Wound Healing. Int J Mol Sci. 2018;19(10).
  3. Schultz G, Chin G, Moldawer L, Diegelmann R. Principles of Wound Healing. In: Fitridge R, Thompson M, editors. Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists: Adelaide (AU): University of Adelaide Press; 2011.
  4. Molnar JA, Underdown MJ, Clark WA. Nutrition and Chronic Wounds. Adv Wound Care (New Rochelle). 2014;3(11):663-81.
  5. Sen CK. Wound healing essentials: let there be oxygen. Wound Repair Regen. 2009;17(1):1-18.
  6. Blackman E, Moore C, Hyatt J, Railton R, Frye C. Topical wound oxygen therapy in the treatment of severe diabetic foot ulcers: a prospective controlled study. Ostomy Wound Manag. 2010;56(6):24-31.
  7. Dissemond J, Kroger K, Storck M, Risse A, Engels P. Topical oxygen wound therapies for chronic wounds: a review. J Wound Care. 2015;24(2):53-4, 6-60, 2-3.
  8. Darrington RS, Godden DJ, Park MS, Ralston SH, Wallace HM. The effect of hyperoxia on the expression of cytokine mRNA in endothelial cells. Biochem Soc Trans. 1997;25(2):292S.
  9. Gordillo GM, Roy S, Khanna S, Schlanger R, Khandelwal S, Phillips G, et al. Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds. Clin Exp Pharmacol Physiol. 2008;35(8):957-64.
  10. Woo KY, Coutts PM, Sibbald RG. Continuous topical oxygen for the treatment of chronic wounds: a pilot study. Adv Skin Wound Care. 2012;25(12):543-7.
  11. Hayes PD, Alzuhir N, Curran G, Loftus IM. Topical oxygen therapy promotes the healing of chronic diabetic foot ulcers: a pilot study. J Wound Care. 2017;26(11):652-60.
  12. Fries RB, Wallace WA, Roy S, Kuppusamy P, Bergdall V, Gordillo GM, et al. Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutat Res. 2005;579(1-2):172-81.
  13. Kaufman H, Gurevich M, Tamir E, Keren E, Alexander L, Hayes P. Topical oxygen therapy stimulates healing in difficult, chronic wounds: a tertiary centre experience. J Wound Care. 2018;27(7):426-33.
  14. Copeland K, Purvis AR. A Retrospective Chart Review of Chronic Wound Patients Treated with Topical Oxygen Therapy. Adv Wound Care (New Rochelle). 2017;6(5):143-52.
  15. Serena TE, Bullock NM, Cole W, Lantis J, Li L, Moore S, et al. Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial. J Wound Care. 2021;30(Sup5):S7-S14.
  16. Tracey AK, Alcott CJ, Schleining JA, Safayi S, Zaback PC, Hostetter JM, et al. The effects of topical oxygen therapy on equine distal limb dermal wound healing. Can Vet J. 2014;55(12):1146-52.
  17. Piantadosi CA. Physiology of hyperbaric hyperoxia. Respiratory care clinics of North America. 1999;5(1):7-19.
  18. Gottrup F, Dissemond J, Baines C, Frykberg R, Jensen PO, Kot J, et al. Use of Oxygen Therapies in Wound Healing. J Wound Care. 2017;26(Sup5):S1-S43.
  19. McCarty SM, Percival SL. Proteases and Delayed Wound Healing. Adv Wound Care (New Rochelle). 2013;2(8):438-47.
  20. Zhu G, Wang Q, Lu S, Niu Y. Hydrogen Peroxide: A Potential Wound Therapeutic Target? Med Princ Pract. 2017;26(4):301-8.
  21. Howard MA, Asmis R, Evans KK, Mustoe TA. Oxygen and wound care: a review of current therapeutic modalities and future direction. Wound Repair Regen. 2013;21(4):503-11.
  22. Schreml S, Szeimies RM, Prantl L, Karrer S, Landthaler M, Babilas P. Oxygen in acute and chronic wound healing. Br J Dermatol. 2010;163(2):257-68.
  23. Bessa LJ, Fazii P, Di Giulio M, Cellini L. Bacterial isolates from infected wounds and their antibiotic susceptibility pattern: some remarks about wound infection. Int Wound J. 2015;12(1):47-52.
  24. Libertucci J, Bassis CM, Cassone M, Gibson K, Lansing B, Mody L, et al. Bacteria Detected in both Urine and Open Wounds in Nursing Home Residents: a Pilot Study. mSphere. 2019;4(4).
  25. Rahim K, Saleha S, Zhu X, Huo L, Basit A, Franco OL. Bacterial Contribution in Chronicity of Wounds. Microb Ecol. 2017;73(3):710-21.
  26. Wong SY, Manikam R, Muniandy S. Prevalence and antibiotic susceptibility of bacteria from acute and chronic wounds in Malaysian subjects. J Infect Dev Ctries. 2015;9(9):936-44.
  27. James GA, Ge Zhao A, Usui M, Underwood RA, Nguyen H, Beyenal H, et al. Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds. Wound Repair Regen. 2016;24(2):373-83.
  28. Gontcharova V, Youn E, Sun Y, Wolcott RD, Dowd SE. A comparison of bacterial composition in diabetic ulcers and contralateral intact skin. Open Microbiol J. 2010;4:8-19.
  29. Jnana A, Muthuraman V, Varghese VK, Chakrabarty S, Murali TS, Ramachandra L, et al. Microbial Community Distribution and Core Microbiome in Successive Wound Grades of Individuals with Diabetic Foot Ulcers. Appl Environ Microbiol. 2020;86(6).
  30. Verbanic S, Shen Y, Lee J, Deacon JM, Chen IA. Microbial predictors of healing and short-term effect of debridement on the microbiome of chronic wounds. NPJ Biofilms Microbiomes. 2020;6(1):21.
  31. Borriello G, Werner E, Roe F, Kim AM, Ehrlich GD, Stewart PS. Oxygen limitation contributes to antibiotic tolerance of Pseudomonas aeruginosa in biofilms. Antimicrob Agents Chemother. 2004;48(7):2659-64.
  32. Nataraj M, Maiya AG, Karkada G, Hande M, Rodrigues GS, Shenoy R, et al. Application of Topical Oxygen Therapy in Healing Dynamics of Diabetic Foot Ulcers - A Systematic Review. Rev Diabet Stud. 2019;15:74-82.
  33. Hunter P, Greco E, Cross K, Perry J. Topical Oxygen Therapy Shifts Microbiome Dynamics in Chronic Diabetic Foot Ulcers. Wounds: a compendium of clinical research and practice. 2020;32(3):81-5.
  34. Kadam S, Shai S, Shahane A, Kaushik KS. Recent Advances in Non-Conventional Antimicrobial Approaches for Chronic Wound Biofilms: Have We Found the 'Chink in the Armor'? Biomedicines. 2019;7(2).
  35. Song Z-B, Guo X, Zhang XJAjotr. Effects of topical oxygen therapy on chronic traumatic wounds and its impact on granulation tissue. Am J Transl Res. 2021;13 6:7294-9.
  36. Otaviano MH, Salles M, Ching TH, Dettoni JL, Coulibaly IGS, Fukunaga ET, et al. Topical Oxygen Jet Therapy (TOJT) for treating infected chronic surgical wounds. Braz J Infect Dis. 2021;25(2):101547.
  37. Ellis S, Lin EJ, Tartar D. Immunology of Wound Healing. Curr Dermatol Rep. 2018;7(4):350-8.
  38. Barrientos S, Brem H, Stojadinovic O, Tomic-Canic M. Clinical application of growth factors and cytokines in wound healing. Wound Repair Regen. 2014;22(5):569-78.
  1. Saleh K, Stromdahl AC, Riesbeck K, Schmidtchen A. Inflammation Biomarkers and Correlation to Wound Status After Full-Thickness Skin Grafting. Front Med (Lausanne). 2019;6:159.
  2. Liu T, Yang F, Li Z, Yi C, Bai X. A prospective pilot study to evaluate wound outcomes and levels of serum C-reactive protein and interleukin-6 in the wound fluid of patients with trauma-related chronic wounds. Ostomy/wound management. 2014;60(6):30-7.
  3. Mutluoglu M, Cakkalkurt A, Uzun G, Aktas S. Topical Oxygen for Chronic Wounds: A PRO/CON Debate. J Am Coll Clin Wound Spec. 2013;5(3):61-5.
  4. Winfield B. Topical oxygen and hyperbaric oxygen therapy use and healing rates in diabetic foot ulcers. Wounds Res. 2014;26:39-47.
  5. He S, Liang C, Yi C, Wu M. Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers. Diabetes Res Clin Pract. 2021;174:108743.
  6. Trabold O, Wagner S, Wicke C, Scheuenstuhl H, Hussain MZ, Rosen N, et al. Lactate and oxygen constitute a fundamental regulatory mechanism in wound healing. Wound Repair Regen. 2003;11(6):504-9.
  7. Constant JS, Feng JJ, Zabel DD, Yuan H, Suh DY, Scheuenstuhl H, et al. Lactate elicits vascular endothelial growth factor from macrophages: a possible alternative to hypoxia. Wound Repair Regen. 2000;8(5):353-60.
  8. Porporato PE, Payen VL, De Saedeleer CJ, Preat V, Thissen JP, Feron O, et al. Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice. Angiogenesis. 2012;15(4):581-92.
  9. Britland S, Ross-Smith O, Jamil H, Smith AG, Vowden K, Vowden P. The lactate conundrum in wound healing: clinical and experimental findings indicate the requirement for a rapid point-of-care diagnostic. Biotechnol Prog. 2012;28(4):917-24.
  10. Nguyen T, Mobashery S, Chang M. Roles of matrix metalloproteinases in cutaneous wound healing: Wound Healing-New insights into Ancient Challenges; 2016.
  11. Ayuk SM, Abrahamse H, Houreld NN. The Role of Matrix Metalloproteinases in Diabetic Wound Healing in relation to Photobiomodulation. J Diabetes Res. 2016;2016:2897656.
  12. Caley MP, Martins VL, O'Toole EA. Metalloproteinases and Wound Healing. Adv Wound Care (New Rochelle). 2015;4(4):225-34.
  1. Driver VR, Yao M, Kantarci A, Gu G, Park N, Hasturk H. A prospective, randomized clinical study evaluating the effect of transdermal continuous oxygen therapy on biological processes and foot ulcer healing in persons with diabetes mellitus. Ostomy Wound Manag. 2013;59(11):19-26.
  2. Hunt TK, Pai MP. The effect of varying ambient oxygen tensions on wound metabolism and collagen synthesis. Surg Gynecol Obstet. 1972;135(4):561-7.
  3. Rappu P, Salo AM, Myllyharju J, Heino J. Role of prolyl hydroxylation in the molecular interactions of collagens. Essays Biochem. 2019;63(3):325-35.
  1. Hutton JJ, Tappel AL, Udenfriend S. Cofactor and substrate requirements of collagen proline hydroxylase. Arch Biochem Biophys. 1967;118(1):231-40.
  2. Myllyla R, Tuderman L, Kivirikko KI. Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence. Eur J Biochem. 1977;80(2):349-57.
  3. Lavery LA, Killeen AL, Farrar D, Akgul Y, Crisologo PA, Malone M, et al. The effect of continuous diffusion of oxygen treatment on cytokines, perfusion, bacterial load, and healing in patients with diabetic foot ulcers. Int Wound J. 2020;17(6):1986-95.
آمار
تعداد مشاهده مقاله: 3,946
تعداد دریافت فایل اصل مقاله: 3,498


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب