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Gasmi, A, Menzel, A, Piscopo, S, Noor, S. (1400). Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders. سامانه مدیریت نشریات علمی, 77(1), 1-10. doi: 10.22092/ari.2021.356078.1771
A Gasmi; A Menzel; S Piscopo; S Noor. "Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders". سامانه مدیریت نشریات علمی, 77, 1, 1400, 1-10. doi: 10.22092/ari.2021.356078.1771
Gasmi, A, Menzel, A, Piscopo, S, Noor, S. (1400). 'Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders', سامانه مدیریت نشریات علمی, 77(1), pp. 1-10. doi: 10.22092/ari.2021.356078.1771
Gasmi, A, Menzel, A, Piscopo, S, Noor, S. Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders. سامانه مدیریت نشریات علمی, 1400; 77(1): 1-10. doi: 10.22092/ari.2021.356078.1771

Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders

Archives of Razi Institute
مقاله 3، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 1-10    اصل مقاله (400.93 K)
نوع مقاله: Review Article
شناسه دیجیتال (DOI): 10.22092/ari.2021.356078.1771
نویسندگان
A Gasmi* 1؛ A Menzel2؛ S Piscopo1، 3؛ S Noor4
1Société Francophone de Nutrithérapie et de Nutrigénétique Appliquée, Villeurbanne, France
2Laboratoires Réunis, Junglinster, Luxembourg
3Research and Development Department, Nutri-Logics SA, Weiswampach, Luxembourg
4Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University Multan, Pakistan
چکیده
Neurodegenerative disorders are those which affect cognitive functions. Misfolding of proteins especially apolipoprotein E is a key genetic factor involved in several cognitive impairments.  Increasing evidence also described the toxic effects of metals, generated by both nature and humans, on the development of neurological disorders. Understanding of interaction between toxic metals and apolipoprotein E protein in cognitive decline diosrders would provide alternative treatment options.  Google Scholar and PubMed database were used to search the articles using different search terms like ‘toxic metals’, ‘cognitive decline’, ‘Apolipoprotein E’, “neurodegenerative disorders” and “metals neurotoxicity”. Only those papers were included that discussed the metal exposure-apolipoprotein association in the development of cognitive decline disorders. Heavy metals are particularly recognized as a major source of neurotoxicity. These toxic metals can interact with genetic factors and play important role in disease etiology. Understanding the underlying mechanism of this interaction could provide tremendous benefits to treat cognitive decline disorders. In this study, the role of the apolipoprotein E4 gene in the development of cognitive disease conditions and their phenotypes has been discussed thoroughly which leads to the accumulation of amyloid-beta fibrils. This exploratory study revealed novel hypothetical findings which might contribute to the understanding of the neurotoxic effects of chronic toxic metals exposure and possibly improve our knowledge on the molecular mechanisms linking metal exposure to cognitive decline disorder risk.
کلیدواژه‌ها
Toxic Metals؛ Brain؛ Apolipoprotein E؛ Neurodegenerative disorders؛ Alzheimer’s disease
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