اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها3,028
تعداد مقالات33,882
تعداد مشاهده مقاله45,253,375
تعداد دریافت فایل اصل مقاله60,280,423
Ebrahimi, Sh, Tahmasebipour, M. (1401). Numerical Study of a Centrifugal Platform for the Inertial Separation of Circulating Tumor Cells Using Contraction-Expansion Array Microchannels. سامانه مدیریت نشریات علمی, 77(2), 647-660. doi: 10.22092/ari.2022.357477.2046
Sh Ebrahimi; M Tahmasebipour. "Numerical Study of a Centrifugal Platform for the Inertial Separation of Circulating Tumor Cells Using Contraction-Expansion Array Microchannels". سامانه مدیریت نشریات علمی, 77, 2, 1401, 647-660. doi: 10.22092/ari.2022.357477.2046
Ebrahimi, Sh, Tahmasebipour, M. (1401). 'Numerical Study of a Centrifugal Platform for the Inertial Separation of Circulating Tumor Cells Using Contraction-Expansion Array Microchannels', سامانه مدیریت نشریات علمی, 77(2), pp. 647-660. doi: 10.22092/ari.2022.357477.2046
Ebrahimi, Sh, Tahmasebipour, M. Numerical Study of a Centrifugal Platform for the Inertial Separation of Circulating Tumor Cells Using Contraction-Expansion Array Microchannels. سامانه مدیریت نشریات علمی, 1401; 77(2): 647-660. doi: 10.22092/ari.2022.357477.2046

Numerical Study of a Centrifugal Platform for the Inertial Separation of Circulating Tumor Cells Using Contraction-Expansion Array Microchannels

Archives of Razi Institute
مقاله 18، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 647-660    اصل مقاله (1.29 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357477.2046
نویسندگان
Sh Ebrahimi1، 2؛ M Tahmasebipour* 1، 2
1Faculty of New Sciences and Technologies, University of Tehran, Tehran, 14395 -1561, Iran
2Micro/Nanofabrication Technologies Lab, Faculty of New Sciences and Technologies, University of Tehran, Tehran, 14395 -1561, Iran
چکیده
Label-free inertial separation of the circulating tumor cells (CTCs) has attracted significant attention recently. The present study proposed a centrifugal platform for the inertial separation of the CTCs from the white blood cells. Particle trajectories of the contraction-expansion array (CEA) microchannels were analyzed by the finite element method. Four expansion geometries (i.e., circular, rectangular, trapezoidal, and triangular) were compared to explore their differences in separation possibilities. Different operational and geometrical parameters were investigated to achieve maximum separation efficiency. Results indicated that the trapezoidal CEA microchannel with ten expansions and a 100 µm channel depth had the best separation performance at an angular velocity of 100 rad/s. Reynolds number of 47 was set as the optimum value to apply minimum shear stress on the CTCs leading to 100% efficiency and 95% purity. Furthermore, the proposed system was simulated for whole blood by considering the red blood cells.
کلیدواژه‌ها
CEA microchannel؛ Centrifugal microfluidic system؛ Lab-on-a-disk؛ Inertial microfluidic؛ Numerical simulation
سایر فایل های مرتبط با مقاله
مراجع
  1. Farahinia A, Zhang WJ, Badea I. Novel microfluidic approaches to circulating tumor cell separation and sorting of blood cells: A review. J Sci-Adv Mater Dev. 2021;6(3):303-20.
  2. Rostami P, Kashaninejad N, Moshksayan K, Saidi MS, Firoozabadi B, Nguyen N-T. Novel approaches in cancer management with circulating tumor cell clusters. J Sci-Adv Mater Dev. 2019;4(1):1-18.
  3. Herath S, Razavi Bazaz S, Monkman J, Ebrahimi Warkiani M, Richard D, O'Byrne K, et al. Circulating tumor cell clusters: Insights into tumour dissemination and metastasis. Expert Rev Mol Diagn. 2020;20(11):1139-47
  4. Lei KF. A review on microdevices for isolating circulating tumor cells. Micromachines. 2020;11(5):531.
  5. Tahmasebipour M, Vafaie A. A novel single axis capacitive MEMS accelerometer with double-sided suspension beams fabricated using μWEDM. Sens Actuator A Phys. 2020;309:112003.
  6. Tahmasebipour M, Modarres M, Salarpoor H, editors. Size Effect on the Deflection and Resonant Frequency of the Timoshenko Microbeam. 5th International Conference on Electrical and Computer Engineering; 2018.
  7. Paknahad AA, Tahmasebipour M. An electromagnetic micro-actuator with PDMS-Fe3O4 nanocomposite magnetic membrane. Microelectron Eng. 2019;216:111031.
  8. Tahmasebipour M, Paknahad AA. Unidirectional and bidirectional valveless electromagnetic micropump with PDMS-Fe3O4 nanocomposite magnetic membrane. J Micromech Microeng.. 2019;29(7):075014.
  9. Tahmasebipour M, Modarres M, Salarpour H, editors. Investigation of Natural Frequency of Epoxy Micro-cantilevers via Finite Element Method and couple stress classical and strain gradient elasticity theories. 5th International Conference on Electrical and Computer Engineering; 2018.
  10. Yue W-Q, Tan Z, Li X-P, Liu F-F, Wang C. Micro/nanofluidic technologies for efficient isolation and detection of circulating tumor cells. TrAC - Trends Anal. Chem. 2019;117:101-15.
  11. Hao S-J, Wan Y, Xia Y-Q, Zou X, Zheng S-Y. Size-based separation methods of circulating tumor cells. Adv Drug Deliv Rev. 2018;125:3-20.
  12. Dalili A, Samiei E, Hoorfar M. A review of sorting, separation and isolation of cells and microbeads for biomedical applications: Microfluidic approaches. Analyst. 2019;144(1):87-113.
  13. Bayareh M. An updated review on particle separation in passive microfluidic devices. Chem Eng Process: Process Intensif. 2020;153:107984.
  14. Warkiani ME, Khoo BL, Wu L, Tay AKP, Bhagat AAS, Han J, et al. Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics. Nat Protoc. 2016;11(1):134-48.
  15. Guan G, Wu L, Bhagat AA, Li Z, Chen PC, Chao S, et al. Spiral microchannel with rectangular and trapezoidal cross-sections for size based particle separation. Sci Rep. 2013;3(1):1-9.
  16. Shiriny A, Bayareh M. Inertial focusing of CTCs in a novel spiral microchannel. Chem Eng Sci. 2021;229:116102.
  17. Lee A, Park J, Lim M, Sunkara V, Kim SY, Kim GH, et al. All-in-one centrifugal microfluidic device for size-selective circulating tumor cell isolation with high purity. Anal Chem. 2014;86(22):11349-56.
  18. Che J, Yu V, Dhar M, Renier C, Matsumoto M, Heirich K, et al. Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology. Oncotarget. 2016;7(11):12748.
  19. Zhang J, Guo Q, Liu M, Yang J. A lab-on-CD prototype for high-speed blood separation. J Micromech Microeng. 2008;18(12):125025.
  20. Kuo J-N, Chen X-F. Decanting and mixing of supernatant human blood plasma on centrifugal microfluidic platform. Microsyst Technol. 2016;22(4):861-9.
  21. Park J-M, Kim MS, Moon H-S, Yoo CE, Park D, Kim YJ, et al. Fully automated circulating tumor cell isolation platform with large-volume capacity based on lab-on-a-disc. Anal Chem. 2014;86(8):3735-42.
  22. La M, Park SJ, Kim HW, Park JJ, Ahn KT, Ryew SM, et al. A centrifugal force-based serpentine micromixer (CSM) on a plastic lab-on-a-disk for biochemical assays. Microfluidics and Nanofluidics. 2013;15(1):87-98.
  23. Morijiri T, Sunahiro S, Senaha M, Yamada M, Seki M. Sedimentation pinched-flow fractionation for size-and density-based particle sorting in microchannels. Microfluidics and nanofluidics. 2011;11(1):105-10.
  24. Maria K, Gerson RA, Vitaly E, Jens D, editors. Lab-on-a disc platform for particle focusing induced by inertial forces. ProcSPIE; 2013.
  1. Aguirre GR, Efremov V, Kitsara M, Ducree J. Integrated micromixer for incubation and separation of cancer cells on a centrifugal platform using inertial and dean forces. Microfluidic Nanofluidics. 2015;18(3):513-26.
  2. Shamloo A, Mashhadian A. Inertial particle focusing in serpentine channels on a centrifugal platform. Phys. Fluids. 2018;30(1):012002.
  3. Al-Halhouli Aa, Doofesh Z, Albagdady A, Dietzel A. High-efficiency small sample microparticle fractionation on a femtosecond laser-machined microfluidic disc. Micromachines. 2020;11(2):151.
  4. Nasiri R, Shamloo A, Akbari J, Tebon P, R Dokmeci M, Ahadian S. Design and simulation of an integrated centrifugal microfluidic device for CTCs separation and cell lysis. Micromachines. 2020;11(7):699.
  5. Tahmasebipour M, Vafaie A. A highly sensitive three axis piezoelectric microaccelerometer for high bandwidth applications. Micro and Nanosystems. 2017;9(2):111-20.
  6. Mirzaaghaian A, Ramiar A, Ranjbar AA, Warkiani ME. Application of level-set method in simulation of normal and cancer cells deformability within a microfluidic device. J Biomech. 2020;112:110066.
  7. Madadelahi M, Acosta-Soto LF, Hosseini S, Martinez-Chapa SO, Madou MJ. Mathematical modeling and computational analysis of centrifugal microfluidic platforms: A review. Lab Chip. 2020;20(8):1318-57.
  8. Carlo DD, Irimia D, Tompkins RG, Toner M. Continuous inertial focusing, ordering, and separation of particles in microchannels. 2007;104(48):18892-7.
  9. Lee MG, Shin JH, Bae CY, Choi S, Park J-K. Label-free cancer cell separation from human whole blood using inertial microfluidics at low shear stress. Anal Chem. 2013;85(13):6213-8.
  10. Ying Y, Lin Y. Inertial focusing and Separation of particles in Similar curved channels. Sci Rep. 2019;9(1):1-12.
  11. Zhou J, Kulasinghe A, Bogseth A, O’Byrne K, Punyadeera C, Papautsky I. Isolation of circulating tumor cells in non-small-cell-lung-cancer patients using a multi-flow microfluidic channel. Microsyst Nanoeng. 2019;5(1):1-12.
  12. Dhar M, Pao E, Renier C, Go DE, Che J, Montoya R, et al. Label-free enumeration, collection and downstream cytological and cytogenetic analysis of circulating tumor cells. Sci Rep. 2016;6(1):1-12.
آمار
تعداد مشاهده مقاله: 1,754
تعداد دریافت فایل اصل مقاله: 2,077


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب