اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,036
تعداد مقالات33,971
تعداد مشاهده مقاله45,666,875
تعداد دریافت فایل اصل مقاله76,594,088
Saravani, Khadijeh, Akbari, Mohammad Ebrahim, Akbari, Mohammad Mahdi, Fazeli-Nasab, Bahman. (1402). The Protective Effect of Hydro-alcoholic Extracts of Cactus Fruit (Opuntia dillenii (Ker Gawl.) Haw.) and Star Fruit (Averrhoa carambola L.) on Histological Changes Induced by Cadmium Chloride in Lungs of Male Wistar Rats. سامانه مدیریت نشریات علمی, 12(3), 267-274. doi: 10.22092/jmpb.2022.356472.1421
Khadijeh Saravani; Mohammad Ebrahim Akbari; Mohammad Mahdi Akbari; Bahman Fazeli-Nasab. "The Protective Effect of Hydro-alcoholic Extracts of Cactus Fruit (Opuntia dillenii (Ker Gawl.) Haw.) and Star Fruit (Averrhoa carambola L.) on Histological Changes Induced by Cadmium Chloride in Lungs of Male Wistar Rats". سامانه مدیریت نشریات علمی, 12, 3, 1402, 267-274. doi: 10.22092/jmpb.2022.356472.1421
Saravani, Khadijeh, Akbari, Mohammad Ebrahim, Akbari, Mohammad Mahdi, Fazeli-Nasab, Bahman. (1402). 'The Protective Effect of Hydro-alcoholic Extracts of Cactus Fruit (Opuntia dillenii (Ker Gawl.) Haw.) and Star Fruit (Averrhoa carambola L.) on Histological Changes Induced by Cadmium Chloride in Lungs of Male Wistar Rats', سامانه مدیریت نشریات علمی, 12(3), pp. 267-274. doi: 10.22092/jmpb.2022.356472.1421
Saravani, Khadijeh, Akbari, Mohammad Ebrahim, Akbari, Mohammad Mahdi, Fazeli-Nasab, Bahman. The Protective Effect of Hydro-alcoholic Extracts of Cactus Fruit (Opuntia dillenii (Ker Gawl.) Haw.) and Star Fruit (Averrhoa carambola L.) on Histological Changes Induced by Cadmium Chloride in Lungs of Male Wistar Rats. سامانه مدیریت نشریات علمی, 1402; 12(3): 267-274. doi: 10.22092/jmpb.2022.356472.1421

The Protective Effect of Hydro-alcoholic Extracts of Cactus Fruit (Opuntia dillenii (Ker Gawl.) Haw.) and Star Fruit (Averrhoa carambola L.) on Histological Changes Induced by Cadmium Chloride in Lungs of Male Wistar Rats

Journal of Medicinal plants and By-products
دوره 12، شماره 3، آذر 2023، صفحه 267-274    اصل مقاله (1.01 M)
نوع مقاله: Research Paper
شناسه دیجیتال (DOI): 10.22092/jmpb.2022.356472.1421
نویسندگان
Khadijeh Saravani1؛ Mohammad Ebrahim Akbari2؛ Mohammad Mahdi Akbari3؛ Bahman Fazeli-Nasab* 4
1Forensic Medicine and Toxicology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran
2Anatomical Sciences, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
3Student Research Committee, Zabol University of Medical Sciences, Zabol, Iran
4Research Department of Agronomy and Plant Breeding, Agricultural Research Institute, University of Zabol, Zabol, Iran
چکیده
Nowadays because of urban life, every vital resource has been polluted with heavy metals that are real prooxidants, Cactus fruit and Star fruit both have anti-oxidant activities and can protect animal tissues from oxidative stress. The purpose of this study was to evaluate the protective effect of Cactus Fruit and Star fruit extract on histological changes induced by cadmium in the lungs of Wistar rats. An experimental study was performed on 24 male Wistar rats over 16 days, Animals were randomly divided into four groups of six; negative control group, the positive control group that was poisoned at 2 mg/kg every 48 hours. Group 3 was the cadmium-poisoned group that was gavaged with cactus fruit extract at 200 mg/kg. Group 4 was the cadmium-poisoned group that was gavaged with star fruit extract at 200 mg/kg, administration of extracts was 90 minutes before the poisoning, After 16 days, the rats were euthanized by heart blood drainage under anesthesia. The main findings in the positive control group were the destruction of tissue architecture with the development of edema, hyperemia and congestion. Destruction of alveoli and air-space enlargement occurred. Vasculature structures were damaged and some degree of Inflammation and fibrosis happened, but the changes were much milder in the two other groups. Both fruits extract had high protective effects, each of them protected lung tissue against cadmium oxidative damage but cactus fruit extract seems to have more protection than star fruit extract.
کلیدواژه‌ها
Alveoli؛ Blood vessels؛ Bronchi and bronchioles؛ Heavy metal؛ Gastrointestinal lumen
مراجع
  1. Rahman Z., Singh V.P. The relative impact of toxic heavy metals (THMs)(arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview. Environmental Monitoring and Assessment. 2019; 191(7): 1-21.
  2. Nawrot T.S., Martens D.S., Hara A., Plusquin M., Vangronsveld J., Roels H.A., Staessen J.A. Association of total cancer and lung cancer with environmental exposure to cadmium: the meta-analytical evidence. Cancer Causes & Control. 2015; 26(9): 1281-1288.
  3. Faroon O., Ashizawa A., Wright S., Tucker P., Jenkins K., Ingerman L., Rudisill C. Toxicological profile for cadmium. Available from:
  4. Aziziaram Z., Bilal I., Zhong Y., Mahmod A.K., Roshandel M.R. Protective effects of curcumin against naproxen-induced mitochondrial dysfunction in rat kidney tissue. Cellular, Molecular and Biomedical Reports. 2021; 1(1): 23-32.
  5. Tourang M, Fang L, Zhong Y, Suthar R C. Association between Human Endogenous Retrovirus K gene expression and breast cancer. Cellular, Molecular and Biomedical Reports. 2021; 1(1): 7-13.
  6. Rezaei-Nasab M., Komeili G., Fazeli-Nasab B. Gastroprotective effects of aqueous and hydroalcholic extract of Scrophularia striata on ethanol-induced gastric ulcers in rats. Der Pharmacia Lettre. 2017; 9(5): 84-93.
  7. Ferramola M.L., Díaz M.F.P., Honoré S.M., Sánchez S.S., Antón R.I., Anzulovich A.C., Giménez M.S. Cadmium-induced oxidative stress and histological damage in the myocardium. Effects of a soy-based diet. Toxicology and Applied Pharmacology. 2012; 265(3): 380-389.
  8. Hayes J., Snider G.L., Palmer K. The evolution of biochemical damage in the rat lung after acute cadmium exposure. American Review of Respiratory Disease. 1976; 113(2): 121-130.
  9. Graham J., Miller F., Daniels M., Payne E., Gardner D. Influence of cadmium, nickel, and chromium on primary immunity in mice. Environmental Res. 1978; 16(1-3): 77-87.
  10. Petering H., Choudhury H., Stemmer K. Some effects of oral ingestion of cadmium on zinc, copper, and iron metabolism. Environmental Health Perspectives. 1979; 28: 97-106.
  11. Takenaka S., Oldiges H., König H., Hochramer D., Oberdörster G. Carcinogenicity of cadmium chloride aerosols in W rats. J. the National Cancer Institute. 1983; 70(2): 367-373.
  12. Cuypers A., Plusquin M., Remans T., Jozefczak M., Keunen E., Gielen H., Opdenakker K., Nair A.R., Munters E., Artois T.J. Cadmium stress: an oxidative challenge. Biometals. 2010; 23(5): 927-940.
  13. Liu J., Qu W., Kadiiska M.B. Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicology and Applied Pharmacology. 2009; 238(3): 209-214.
  14. Ognjanović B.I., Marković S.D., Ðorđević N.Z., Trbojević I.S., Štajn A.Š., Saičić Z.S. Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q10 and Vitamin E. Reproductive Toxicology. 2010; 29(2): 191-197. https://doi.org/10.1016/j.reprotox.2009.11.009
  15. Fazeli-Nasab B., Yazdanpour Z. Antimicrobial effects of extract of Citrullus colocynthis and Teucrium polium on some Bacteria. New Findings in Veterinary Microbiology. 2020; 3(1): 1-10.
  16. Chang S-F., Hsieh C-L., Yen G-C. The protective effect of Opuntia dillenii Haw fruit against low-density lipoprotein peroxidation and its active compounds. Food Chemistry. 2008; 106(2): 569-575.
  17. Butera D., Tesoriere L., Di Gaudio F., Bongiorno A., Allegra M., Pintaudi A.M., Kohen R., Livrea M.A. Antioxidant activities of Sicilian prickly pear (Opuntia ficus indica) fruit extracts and reducing properties of its betalains: betanin and indicaxanthin. J. Agric and Food Chemistry. 2002; 50(23): 6895-6901.
  18. Saeidi S., Fazeli-Nasab B. Evaluation of antibacterial and antifungal activity of various extracts of the Rhazya stricta, Capparis spinosa, cretica Cressa. New Findings in Veterinary Microbiology. 2019; 2(1): 57-66.
  19. Fazeli-Nasab B., Rahnama M., Shahriari S. The antimicrobial properties of hydro-alcoholic extracts of 29 medicinal plants on E. Coli and Staphylococcus aureus microbes. New Findings in Veterinary Microbiology. 2019; 1(2): 1-15.
  20. Fazeli-Nasab B. Evaluation of Antibacterial Activities of Hydroalcoholic Extract of Saffron Petals on Some Bacterial Pathogens. J. Medical Bacteriology. 2019; 8(5, 6)): 8-20.
  21. Rahnama M., Fazeli-Nasab B., Mazarei A., Shahriari A. Evaluation of antimicrobial activity hydro alcoholic extract of some medicinal herbs against a range of Gram-positive and gram-negative bacteria. New Findings in Veterinary Microbiology. 2018; 1(1): 1-18.
  22. Shirazinia R., Hajinezhad M.R., Jamshidian A, Samzadeh K A R, Hasanein P. Effects of Averrhoa carambola hydro-alcoholic extract on acute lead-acetate-induced liver toxicity in rats. J. Isfahan Medical School (I.U.M.S). 2017; 34(411): 1531-1536.
  23. Fazeli-Nasab B., Sayyed R.Z., Sobhanizadeh A. In Silico Molecular Docking Analysis of α-Pinene: An Antioxidant and Anticancer Drug Obtained from Myrtus communis. Int. J. Cancer Manag. 2021; 14(2): e89116.
  24. Marini H.R., Puzzolo D., Micali A., Adamo E.B., Irrera N., Pisani A., Pallio G., Trichilo V., Malta C., Bitto A. Neuroprotective effects of polydeoxyribonucleotide in a murine model of cadmium toxicity. Oxidative Medicine and Cellular Longevity. 2018; 2018: Article ID: 4285694.
  25. Snider G.L., Lucey E.C., Faris B., Jung-Legg Y., Stone P.J., Franzblau C. Cadmium-chloride-induced air-space enlargement with interstitial pulmonary fibrosis is not associated with destruction of lung elastin: Implications for the pathogenesis of human emphysema. American J. Respiratory and Critical Care Medicine. 1988; 137(4): 918-923. PubMed: 3355000;
  26. McKenna I.M., Waalkes M.P., Chen L.C., Gordon T. Comparison of inflammatory lung responses in Wistar rats and C57 and DBA mice following acute exposure to cadmium oxide fumes. Toxicology and Applied Pharmacology. 1997; 146(2): 196-206.
  27. Pearson C.A., Lamar P.C., Prozialeck W.C. Effects of cadmium on E-cadherin and VE-cadherin in mouse lung. Life Sci. 2003; 72(11): 1303-1320.
  28. Frankel F.R., Steeger J.R., Damiano V.V., Sohn M., Oppenheim D., Weinbaum G. Induction of unilateral pulmonary fibrosis in the rat by cadmium chloride. Am J Respir Cell Mol Biol. 1991; 5(4): 385-394.
  29. Bell R.R., Nonavinakere V.K., Soliman M.R. Intratracheal exposure of the guinea pig lung to cadmium and/or selenium: a histological evaluation. Toxicology Letters. 2000; 114(1-3): 101-109.
  30. Vijaya P., Sharma S. Protective Role of Lycopene on Cadmium Induced Lung Injury. Indian J. Applied Res. 2019; 9(7): 30-32.
  31. Kutzman R., Drew R., Shiotsuka R., Cockrell B. Pulmonary changes resulting from subchronic exposure to cadmium chloride aerosol. Journal of Toxicology and Environmental Health, Part A Current Issues. 1986; 17(2-3): 175-189.
  32. Driscoll K.E., Maurer J.K., Poynter J., Higgins J., Asquith T., Miller N.S. Stimulation of rat alveolar macrophage fibronectin release in a cadmium chloride model of lung injury and fibrosis. Toxicology and Applied Pharmacology. 1992; 116(1): 30-37.
  33. Hfaiedh N., Allagui M.S., Hfaiedh M., El Feki A., Zourgui L., Croute F. Protective effect of cactus (Opuntia ficus indica) cladode extract upon nickel-induced toxicity in rats. Food and Chemical Toxicology. 2008; 46(12): 3759-3763.
  34. Li W., Wu D., Wei B., Wang S., Sun H., Li X., Zhang F., Zhang C., Xin Y. Anti-tumor effect of cactus polysaccharides on lung squamous carcinoma cells (SK-MES-1). African J. Traditional, Complementary and Alternative Medicines. 2014; 11(5): 99-104.
  35. Feugang J.M., Ye F., Zhang D.Y., Yu Y., Zhong M., Zhang S., Zou C. Cactus pear extracts induce reactive oxygen species production and apoptosis in ovarian cancer cells. Nutrition and Cancer. 2010; 62(5): 692-699.
  36. Medina E.D., Rodríguez E.R., Romero C.D. Chemical characterization of Opuntia dillenii and Opuntia ficus indica fruits. Food Chemistry. 2007; 103(1): 38-45.
  37. Serra A.T., Poejo J., Matias A.A., Bronze M.R., Duarte C.M. Evaluation of Opuntia spp. derived products as antiproliferative agents in human colon cancer cell line (HT29). Food Res. Int. 2013; 54(1): 892-901. https://doi.org/10.1016/j.foodres.2013.08.043
  38. Aladaileh SH., Saghir S.A., Murugesu K., Sadikun A., Ahmad A., Kaur G., Mahmoud A.M., Murugaiyah V. Antihyperlipidemic and antioxidant effects of Averrhoa carambola extract in high-fat diet-fed rats. Biomedicines. 2019; 7(3): 72.
  39. Dasgupta P., Chakraborty P., Bala N. Averrhoa carambola: an updated review. International J. Pharma Res. Review. 2013; 2(7): 54-63.
  40. Thomas R., Jebin N., Saha R., Sarma D. Antioxidant and antimicrobial effects of kordoi (Averrhoa carambola) fruit juice and bamboo (Bambusa polymorpha) shoot extract in pork nuggets. Food Chemistry. 2016; 190: 41-49. https://doi.org/10.1016/j.foodchem.2015.05.070
  41. Thomas S., Patil D., Patil A., Chandra N. Pharmacognostic evaluation and physicochemical analysis of Averrhoa carambola L. fruit. J. Herb Med Toxicol. 2008; 2(2): 51-54.
  42. Yan S.W., Ramasamy R., Alitheen N.B.M., Rahmat A. A comparative assessment of nutritional composition, total phenolic, total flavonoid, antioxidant capacity, and antioxidant vitamins of two types of Malaysian underutilized fruits (Averrhoa bilimbi and Averrhoa carambola). International J. Food Properties. 2013; 16(6): 1231-1244.
  43. Zainudin M.A.M., Hamid A.A., Anwar F., Osman A., Saari N. Variation of bioactive compounds and antioxidant activity of carambola (Averrhoa carambola L.) fruit at different ripening stages. Scientia Horticulturae. 2014; 172: 325-331.
  44. Goncalves S.T., Baroni S., Bersani-Amado F.A., Melo G.A., Cortez D.A., Bersani-Amado C.A., Cuman R.K. Preliminary studies on gastric anti-ulcerogenic effects of Averrhoa carambola in Rats. Acta Farmaceutica Bonaerense. 2006; 25(2): 245.
  45. Sripanidkulchai B., Tattawasart U., Laupattarakasem P., Wongpanich V. Anti-inflammatory and bactericidal properties of selected indigenous medicinal plants used for dysuria. Thai J. Pharm Sci. 2002; 26(1-2): 33-38.
  46. Tadros S., Sleem A. Pharmacognostical and biological study of the stem and leaf of Avehrroa carambola L. Bull Fac Pharm. 2004; 42: 225-246.
آمار
تعداد مشاهده مقاله: 703
تعداد دریافت فایل اصل مقاله: 586


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب