اخبار و اعلانات

 آمار

تعداد نشریات283
تعداد نشریات سازمان81
تعداد شماره‌ها2,727
تعداد مقالات31,057
تعداد مشاهده مقاله28,401,367
تعداد دریافت فایل اصل مقاله16,276,342
Al-Eqabi, S. R. S, Ismail Ibrahim, Z, Jamal Mohammed Jawad, Z. (1400). Immunopathological Changes Post-Infection with Enterobacter cloacae in Rabbits. سامانه مدیریت نشریات علمی, 77(1), 179-186. doi: 10.22092/ari.2022.357468.2044
S. R. S Al-Eqabi; Z Ismail Ibrahim; Z Jamal Mohammed Jawad. "Immunopathological Changes Post-Infection with Enterobacter cloacae in Rabbits". سامانه مدیریت نشریات علمی, 77, 1, 1400, 179-186. doi: 10.22092/ari.2022.357468.2044
Al-Eqabi, S. R. S, Ismail Ibrahim, Z, Jamal Mohammed Jawad, Z. (1400). 'Immunopathological Changes Post-Infection with Enterobacter cloacae in Rabbits', سامانه مدیریت نشریات علمی, 77(1), pp. 179-186. doi: 10.22092/ari.2022.357468.2044
Al-Eqabi, S. R. S, Ismail Ibrahim, Z, Jamal Mohammed Jawad, Z. Immunopathological Changes Post-Infection with Enterobacter cloacae in Rabbits. سامانه مدیریت نشریات علمی, 1400; 77(1): 179-186. doi: 10.22092/ari.2022.357468.2044

Immunopathological Changes Post-Infection with Enterobacter cloacae in Rabbits

Archives of Razi Institute
مقاله 25، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 179-186    اصل مقاله (2.19 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357468.2044
نویسندگان
S. R. S Al-Eqabi* 1؛ Z Ismail Ibrahim2؛ Z Jamal Mohammed Jawad2
1Department of Public Health, College of Veterinary Medicine, Wasit University, Wasit, Iraq
2Department of Pathology and Poultry Diseases, College of Veterinary Medicine, University of Baghdad, Baghdad, Iraq
چکیده
Nosocomial infections have serious effects on health conditions in humans and animals. The present study aimed to investigate the pathogenesis of Enterobacter cloacae post intraperitoneal inoculation in rabbits to investigate the immunological and possible pathological effects. A total of 42 rabbits were randomly divided into two equal groups (n=21). The first group was inoculated with 3×108 CFU/ml of the virulent isolate of E. cloacae intraperitoneally (IP), while the second group was injected IP with phosphate buffer saline and considered a control negative group. The animals were sacrificed at different time post-infection at 48/72 h, and at day 7 post-bacterial inoculation. The results revealed a significant increase in the concentration of TNF-α, especially in the infected groups. In addition, there were different pathological lesions in different organs of animals, mainly in the infected groups, which represents by vascular congestion and edema with polymorphoneutrophiles infiltration in the lungs, kidneys, and heart. This study is considered the first trial which aimed to observe the pathological changes of E. cloacae in vital organs in rabbits.
کلیدواژه‌ها
Enterobacter cloacae؛ Histopathology؛ Immune responses؛ Pathogenesis
سایر فایل های مرتبط با مقاله
مراجع
  1. Mezzatesta ML, Gona F, Stefani S. Enterobacter cloacae complex: clinical impact and emerging antibiotic resistance. Future Microbiol. 2012;7(7):887-902.
  2. Soteras AR, Mackay AS, Borràs-Maixenchs N, Martí JA. Catheter related necrotizing fascitiis in haematological patients: Case report and implications for nursing. Ann Oncol. 2019;30:v843.
  3. Köse S, Özer E, Gülay Z, Akkoçlu G, Tokgöz H, Agus N, et al. Enterobacter cloacae sepsis outbreak in neonatal intensive care unit due to contaminated total parenteral nutrition solution. Pediatr Res. 2016;3(2):109.
  4. Pestourie N, Garnier F, Barraud O, Bedu A, Ploy M-C, Mounier M. Outbreak of AmpC β-lactamase-hyper-producing Enterobacter cloacae in a neonatal intensive care unit in a French teaching hospital. Am J Infect Control. 2014;42(4):456-8.
  5. Hoffmann H, Roggenkamp A. Population genetics of the nomenspecies Enterobacter cloacae. Appl Environ Microbiol. 2003;69(9):5306-18.
  6. Antony B, Prasad BR. An outbreak of neonatal septicaemia by Enterobacter cloacae. Asian Pac J Trop Dis. 2011;1(3):227-9.
  7. Zhou Q, Zhang M, Wang A, Xu J, Yuan Y. Eight-year surveillance of antimicrobial resistance among Enterobacter cloacae isolated in the first Bethune hospital. Phys Procedia. 2012;33:1194-6.
  8. Zhang D, He W, Tong Q, Zhou J, Su X. Multi-omics analysis on the pathogenicity of Enterobacter cloacae ENHKU01 isolated from sewage outfalls along the Ningbo coastline. Proteome Sci. 2016;14(1):1-14.
  9. Suvarna KS, Layton C, Bancroft JD. Bancroft's theory and practice of histological techniques E-Book: Elsevier Health Sciences; 2018.
  10. Snedecor GW, Cochran WG. Statistical methods Iowa state university press. 1967.
  11. Oleiwis SR, Najim SS, Radif HM. Morphological and Molecular Study of Biofilm Formation by Enterobacter cloacae. Ann Trop Med Public Health. 2021;24:176-86.
  12. Davin-Regli A. Enterobacter aerogenes and Enterobacter cloacae; versatile bacterial pathogens confronting antibiotic treatment. Front Microbiol. 2015;6:392.
  13. Kim S-M, Lee H-W, Choi Y-W, Kim S-H, Lee J-C, Lee Y-C, et al. Involvement of curli fimbriae in the biofilm formation of Enterobacter cloacae. J Microbiol. 2012;50(1):175-8.
  14. Zogaj X, Bokranz W, Nimtz M, Römling U. Production of cellulose and curli fimbriae by members of the family Enterobacteriaceae isolated from the human gastrointestinal tract. Infect Immun. 2003;71(7):4151-8.
  1. Dueholm MS, Albertsen M, Otzen D, Nielsen PH. Curli functional amyloid systems are phylogenetically widespread and display large diversity in operon and protein structure. PloS one. 2012;7(12):51274.
  2. Akbari M, Bakhshi B, Najar-Peerayeh S, Behmanesh M. The curli biogenesis genes expression level is unassociated with Enterobacter cloacae hsp60 clusters and PFGE genotypes. Microb Pathog. 2016;98:112-7.
17.          Surbatovic M, Popovic N, Vojvodic D, Milosevic I, Acimovic G, Stojicic M, et al. Cytokine profile in severe Gram-positive and Gram-negative abdominal sepsis. Sci Rep. 2015;5(1):1-12.

آمار
تعداد مشاهده مقاله: 559
تعداد دریافت فایل اصل مقاله: 305


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب