اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,034
تعداد مقالات33,949
تعداد مشاهده مقاله45,420,611
تعداد دریافت فایل اصل مقاله69,233,511
Sadeq AL-Ethari, A, Hayder Hasan, T, Abbas Tikki, K, Sabah Bustani, G. (1401). Genotypic Detection of qnrA and qnrC Genes in Citrobacter koseri Isolated from Patients with Urinary Tract Infection. سامانه مدیریت نشریات علمی, 77(2), 675-680. doi: 10.22092/ari.2022.357122.1979
A Sadeq AL-Ethari; T Hayder Hasan; K Abbas Tikki; G Sabah Bustani. "Genotypic Detection of qnrA and qnrC Genes in Citrobacter koseri Isolated from Patients with Urinary Tract Infection". سامانه مدیریت نشریات علمی, 77, 2, 1401, 675-680. doi: 10.22092/ari.2022.357122.1979
Sadeq AL-Ethari, A, Hayder Hasan, T, Abbas Tikki, K, Sabah Bustani, G. (1401). 'Genotypic Detection of qnrA and qnrC Genes in Citrobacter koseri Isolated from Patients with Urinary Tract Infection', سامانه مدیریت نشریات علمی, 77(2), pp. 675-680. doi: 10.22092/ari.2022.357122.1979
Sadeq AL-Ethari, A, Hayder Hasan, T, Abbas Tikki, K, Sabah Bustani, G. Genotypic Detection of qnrA and qnrC Genes in Citrobacter koseri Isolated from Patients with Urinary Tract Infection. سامانه مدیریت نشریات علمی, 1401; 77(2): 675-680. doi: 10.22092/ari.2022.357122.1979

Genotypic Detection of qnrA and qnrC Genes in Citrobacter koseri Isolated from Patients with Urinary Tract Infection

Archives of Razi Institute
مقاله 21، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 675-680    اصل مقاله (404.35 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.357122.1979
نویسندگان
A Sadeq AL-Ethari1؛ T Hayder Hasan* 1؛ K Abbas Tikki1؛ G Sabah Bustani2، 3
1Department of Medical Laboratory Techniques, Faculty of Medical and Health Techniques, University of Alkafeel, Najaf, Iraq
2Department of Physiology and Pharmacology, College of Nursing, Altoosi University College, Najaf, Iraq
3College of Dentistry, Islamic University, Najaf, Iraq
چکیده
The urinary tract infection (UTI) is a prevalent infection that affects people of all ages. Bacterial agents are the most common causes of UTIs. Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and other staphylococcal species, Citrobacter freundii and Citrobacter koseri (C. koseri) account for a smaller number of infections. These pathogens are transported into the urinary tract from the colonic biotope into dysbacteriosis. Urine samples were randomly collected from 249 outpatients who were suspected of having UTIs. After genital cleaning, 10 mL of urine specimens were collected in a sterilized bowel. Then, the specimens were centrifuged at 2,000 rpm for 5 min and the residue was aerobically incubated with the broth infusion of brain flasks at 37°C for 24 h and then applied with a sterile ring onto blood agar plates and MacConkey agar (OxoidTM). Out of 249 urine samples, the results proved that there were 176 (70.7%) and 51(20.5%) gram-negative and gram-positive bacteria isolates, respectively. However, the results demonstrated that there were 22 (8.8%) urine samples with no growth. In addition, the results showed that eight various antimicrobials are used to treat C. koseri. In the current study, C. koseri was treated with eight different antimicrobial agents. The antimicrobial resistance rate for 7 isolates against Cefotaxime, Ceftriaxone, Ciprofloxacin, and Levofloxacin was high for 6 (85.71%) isolates. The results indicated that 6 and 5 isolates had 85.71% and 71.42% antimicrobial resistance against Ceftazidime and Levofloxacin, respectively. Whereas Gentamicin showed a moderate rate of resistance (4 isolates, 57.14%), and Amikacin resistance was found in 5 isolates, accounting for 28.57%. As shown in table 3, the bacterial isolates had a high susceptibility rate to Imipenem. The qnrA gene was found in 6 (85.71%) isolates. However, the recorded data demonstrated that there is no isolate carrying the qnrC gene. Among all pathogenic bacteria, C. koseri was the lowest causative agent of UTI in this study and was highly resistant to most antimicrobials except Imipenem, which was a good antibiotic with 100% sensitivity.
کلیدواژه‌ها
Antimicrobials؛ Bacterial agents؛ Citrobacter koseri؛ UTI
سایر فایل های مرتبط با مقاله
مراجع
  1. Kwaees T, Hakim Z, Weerasinghe C, Dunkow P. Musculoskeletal infections associated with Citrobacter koseri. Ann R Coll Surg Engl. 2016;98(7):446-9.
  2. Liu H-W, Chang C-J, Hsieh C-T. Brain abscess caused by Citrobacter koseri infection in an adult. Neurosci J. 2015;20(2):170-2.
  3. Marecos CV, Ferreira M, Ferreira MM, Barroso MR. Sepsis, meningitis and cerebral abscesses caused by Citrobacter koseri. Case Rep. 2012;2012:bcr1020114941.
  4. Perilli M, Mugnaioli C, Luzzaro F, Fiore M, Stefani S, Rossolini GM, et al. Novel TEM-type extended-spectrum β-lactamase, TEM-134, in a Citrobacter koseri clinical isolate. Antimicrob Agents Chemother. 2005;49(4):1564-6.
  5. Ariza-Prota MA, Pando-Sandoval A, García-Clemente M, Fernández R, Casan P. Community-acquired pneumonia and empyema caused by Citrobacter koseri in an immunocompetent patient. Case Rep Pulmonol. 2015;2015.
  6. Yuan C, Yin Z, Wang J, Qian C, Wei Y, Zhang S, et al. Comparative genomic analysis of Citrobacter and key genes essential for the pathogenicity of Citrobacter koseri. Front Microbiol. 2019;10:2774.
  7. Ando T, Noguchi S, Enokida T, Yamato A, Kage H, Yamauchi Y, et al. Infectious Aneurysm Caused by Citrobacter koseri in an Immunocompetent Patient. Intern Med. 2019:1806-18.
  8. Townsend SM, Pollack HA, Gonzalez-Gomez I, Shimada H, Badger JL. Citrobacter koseri brain abscess in the neonatal rat: survival and replication within human and rat macrophages. Infect Immun. 2003;71(10):5871-80.
  9. Adam RW, Al-Labban HMY, Kadhim IN, Aljanaby AAJ. Synthesis, characterization, and antibacterial activity of some new pyrimidine derivatives from chalcone derivatives. Drug Invent Today. 2019;11(7):1732-9.
  10. Hayder T, Aljanaby AAJJ. Antibiotics susceptibility patterns of Citrobacter freundii isolated from patients with urinary tract infection in Al-Najaf governorate–Iraq. Int J Pharm Sci Res. 2019;10(2):1481-8.
  11. Hazen TH, Mettus RT, McElheny CL, Bowler SL, Doi Y, Rasko DA. Draft Genome Sequences of bla KPC-Containing Enterobacter aerogenes, Citrobacter freundii, and Citrobacter koseri Strains. Genome Announc. 2018;6(8):00035-18.
  12. Lechowicz M, Dąbek K, Majewska U, Bekesińska-Figatowska M, Borszewska-Kornacka MK, Bokiniec R. Multiple brain abscesses caused by Citrobacter koseri in a preterm neonate–case report. Pol J Radiol. 2017;82:837.
  13. Witwit IN, Mubark HM, Al-Labban HMY, Aljanaby AAJ. Synthesis and characterization of new imidazole azo ligand with some of transition metal ions, and their biological effect on two pathogenic bacteria of burn patients. Int J Pharm Sci Res. 2019;10(3):1847-56.
  14. Mohy AA, Aljanaby AAJ, Al-Hadraawy SK. Evaluation of Eosinophilic cationic protein and some immunological markers in patients infected with Scabies. J Pure Appl Microbiol. 2019;13(3):1737-43.
  15. Hasan TH, Shlash S, Jasim S, Hussein EF, Alasedi KK, Aljanaby AA. The Epidemiology of Klebsiella Pneumoniae: A Review. Ann Rom Soc Cell Biol. 2021:8848-60.
  16. Majeed HT, Hasan TH, Aljanaby A. Epidemiological study in women infected with toxoplasma gondii, rubella virus, and cytomegalo virus in Al-Najaf Governorate-Iraq. Int J Pharm Sci Res. 2020;12:1442-7.
  17. Mohamed Kg, Aljanaby Aaj. Urinary tract infections in Al-Kufa City Iraq and phenotypic detection of antimicrobial sensitivity pattern of bacterial isolates. Int J Pharm Res. 2020;1.
  18. Kadhum HA, Hasan TH. The study of bacillus subtils antimicrobial activity on some of the pathological isolates. Int J Drug Deliv Technol. 2019;9(02):193-6.
  19. Hasan TH, Al-Harmoosh RA. Mechanisms of antibiotics resistance in bacteria. Sys Rev Pharm. 2020;11(6):817-23.
  20. Hasan T, Al-Harmoosh R, Al-Khilkhali H. Identification of HIV virus in najaf city, Iraq. Int J Pharm Sci Res. 2020;11(3):4866-71.
  21. Hasan TH. Extended Spectrum Beta Lactamase E. Coli isolated from UTI Patients in Najaf Province, Iraq. Int J Pharm Res. 2020;12(4).
  1. Abusaiba THH. Prevalence of hepatitis virus B and C in patients in Al Najaf Governorate, Iraq. Int J Pharm Sci Res. 2020;12(3):1297-303.
  2. Mohammed E, Aljanaby A. Immunological role of CD4 and CD154 in patients infected with S. typhi in Al-Najaf Governorate, Iraq. Int J Pharm Sci Res. 2020;12(3).
آمار
تعداد مشاهده مقاله: 1,733
تعداد دریافت فایل اصل مقاله: 2,347


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب