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Abdulhameed Nuri Shamsa, R, Ali Al-Dahhan, H. A. (1401). Correlation of COVID-19 Receptors with Neutrophils and Their Role in the Adherence of Co-Infected Bacteria. سامانه مدیریت نشریات علمی, 77(2), 779-784. doi: 10.22092/ari.2022.356974.1951
R Abdulhameed Nuri Shamsa; H. A Ali Al-Dahhan. "Correlation of COVID-19 Receptors with Neutrophils and Their Role in the Adherence of Co-Infected Bacteria". سامانه مدیریت نشریات علمی, 77, 2, 1401, 779-784. doi: 10.22092/ari.2022.356974.1951
Abdulhameed Nuri Shamsa, R, Ali Al-Dahhan, H. A. (1401). 'Correlation of COVID-19 Receptors with Neutrophils and Their Role in the Adherence of Co-Infected Bacteria', سامانه مدیریت نشریات علمی, 77(2), pp. 779-784. doi: 10.22092/ari.2022.356974.1951
Abdulhameed Nuri Shamsa, R, Ali Al-Dahhan, H. A. Correlation of COVID-19 Receptors with Neutrophils and Their Role in the Adherence of Co-Infected Bacteria. سامانه مدیریت نشریات علمی, 1401; 77(2): 779-784. doi: 10.22092/ari.2022.356974.1951

Correlation of COVID-19 Receptors with Neutrophils and Their Role in the Adherence of Co-Infected Bacteria

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مقاله 35، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 779-784    اصل مقاله (718.37 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2022.356974.1951
نویسندگان
R Abdulhameed Nuri Shamsa* ؛ H. A Ali Al-Dahhan
Laboratory Investigation Department, Faculty of Science, University of Kufa, Kufa, Iraq
چکیده
The COVID-19 caused by the SARS-CoV-2 virus has an impact on all aspects of patient care. Since the onset of this disease pandemic in 2019, numerous studies have been published which have attempted to identify virus receptors in the upper respiratory tract, such as nasal, oropharynx, and lung and their role in coinfection of bacterial adherence. In this study, the level of m RNA for platelet-activating factor receptor (PAF-R) and angiotensin-converting enzyme 2 receptor (ACE2-R) were detected in the whole blood of COVID-19 patients and controlled by using real-time reverse transcription-polymerase chain reaction technique. The results of the expression level of the PAF-R gene were higher in patients (43 ± 12.5) than in the healthy control (40 ± 2.1). Moreover, the expression level of ACE2-R was significantly (0.0001) increased in patients (27.5±6.2), compared to the control group. In addition, there was an elevation of neutrophils (79.6±17.6%) and PAF-R level (43%) in COVID-19 patients in comparison to the control (40) with a positive correlation between these factors (r=0.8769, P=0.0001). Nasopharyngeal epithelial cells showed a higher adherence rate (86%) to both bacteria isolates (Streptococcus pneumonia and Staphylococcus aureus) in patients than in the control group. Increased expression of PAF-R and ACE2-R genes in COVID-19 patients and co-infected bacteria disease could be the factors for the SARS-CoV-2 virus to enter the cells of the host.
کلیدواژه‌ها
ACE2-R؛ COVID-19؛ Neutrophil؛ PAF-R؛ RT-PCR؛ Staphylococcus aureus؛ Streptococcus pneumonia
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مراجع
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