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Shalikar, M, Zendehdel, M, Vazir, B, Asghari, A. (1400). Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken. سامانه مدیریت نشریات علمی, 76(6), 1735-1744. doi: 10.22092/ari.2021.354188.1626
M Shalikar; M Zendehdel; B Vazir; A Asghari. "Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken". سامانه مدیریت نشریات علمی, 76, 6, 1400, 1735-1744. doi: 10.22092/ari.2021.354188.1626
Shalikar, M, Zendehdel, M, Vazir, B, Asghari, A. (1400). 'Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken', سامانه مدیریت نشریات علمی, 76(6), pp. 1735-1744. doi: 10.22092/ari.2021.354188.1626
Shalikar, M, Zendehdel, M, Vazir, B, Asghari, A. Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken. سامانه مدیریت نشریات علمی, 1400; 76(6): 1735-1744. doi: 10.22092/ari.2021.354188.1626

Impact of the Central Histaminergic and Melanocortin Systems on Leptin-Induced Hypophagia in Neonatal Layer Chicken

Archives of Razi Institute
مقاله 19، دوره 76، شماره 6، بهمن و اسفند 2021، صفحه 1735-1744  XML اصل مقاله (862 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.354188.1626
نویسندگان
M Shalikar1؛ M Zendehdel email 2؛ B Vazir1؛ A Asghari3
1Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, 14155-6453, Tehran, Iran
3Department of Clinical Science, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
The present study aimed to assess the probable impact of the central histaminergic and melanocortin systems on leptin-induced hypophagia in neonatal layer chickens. In experiment 1, the chickens received intracerebroventricular (ICV) injections of the control solution, 250 nmol of α-FMH, 10 µg of leptin, and α-FMH+leptin. Experimental groups 2-8 were injected the same as experiment 1. Nonetheless, the chickens in experiments 2-8 received ICV injections of 300 nmol of chlorpheniramine (H1 receptor antagonist), 82 nmol of famotidine (H2 receptor antagonist), 300 nmol of thioperamide (H3 receptor antagonist), 0.5 nmol of SHU9119 (M3/M4 receptors antagonist), 0.5 nmol of MCL0020 (M4 receptor antagonist), 30 µg of astressin-B (CRF1/ CRF2 receptors antagonist), and 30 µg of astressin2-B (CRF2 receptor antagonist), instead of α-FMH, respectively. Food was provided for the birds immediately following the injection, and 30, 60, and 120 min after the injection, cumulative food intake (g) was measured. The findings pointed out that the ICV injection of leptin diminished food intake in neonatal chickens (P<0.05). The co-administration of M3/M4 receptor antagonist+leptin significantly decreased the hypophagic effect of leptin (P<0.05). A significant decrease was also detected in the hypophagic effect of leptin following the co-administration of the M4 receptor antagonist and leptin (P<0.05). Moreover, the co-injection of the antagonists of CRF1/CRF2 receptors and leptin significantly mitigated the hypophagic effect of leptin (P<0.05). The co-injection of CRF2 receptor antagonist and leptin led to a decrease in the hypophagic effect of leptin. As evidenced by the results of the current study the hypophagic effect of leptin is mediated by the receptors of H1, H3, M3/M4, and CRF1/CRF2 in neonatal layer chicken.
کلیدواژه‌ها
Histaminergic؛ Melanocortin؛ Leptin؛ Food intake؛ Neonatal layer chicken
عنوان مقاله [English]
بررسی تداخل سیستم های ملانوکورتینی و هیستامینرژیک مرکزی بر اخذ غذای ناشی از لپتین در جوجه های تخمگذار
چکیده [English]
مطالعه حاضر به منظور بررسی تداخل سیستم های ملانوکورتینی و هیستامینرژیک مرکزی بر اخذ غذای ناشی از لپتین در جوجه های تخمگذار انجام شد. در آزمایش 1، جوجه‌ها، تزریقات داخل بطن مغزی (ICV) را به فرم زیر دریافت کردند: سالین، α-FMH (250 نانومول)، leptin (10 میکروگرم) و leptin + α-FMH را دریافت کردند. آزمایش 2 الی 8 مشابه آزمایش 1 بود به استثنا اینکه جوجه‌ها با Chlorpheniramine (آنتاگونیست گیرنده H1 هیستامینی، 300 نانومول)، famotidine (آنتاگونیست گیرنده H2 هیستامینی، 82 نانومول)، Thioperamide (آنتاگونیست گیرنده H3 هیستامینی، 300 نانومول)، SHU9119 (آنتاگونیست گیرنده های M3/M4 ملانوکورتینی 5/0 نانومول)، MCL0020 (آنتاگونیست گیرنده های M4 ملانوکورتینی 5/0 نانومول)، astressin-B (آنتاگونیست گیرنده‌های CRF1/ CRF2 30 میکروگرم) و astressin2-B (آنتاگونیست گیرنده‌های CRF2 30 میکروگرم) را بجای α-FMH دریافت کردند. سپس مصرف تجمعی غذا تا 120 دقیقه بعد از تزریق اندازه‌گیری شد. با توجه به نتایج بدست آمده، تزریق داخل بطنی مغزی لپتین (10 میکروگرم) موجب کاهش مصرف غذا در جوجه‌های تخمگذار شد (P≤0.05). تزریق توام لپتین +α-FMH یا لپتین + chlorpheniramine موجب مهار اثرات هیپوفاژیک ناشی از لپتین شد (P≤0.05). تزریق لپتین + thioperamide موجب تقویت کاهش اشتهای ناشی از لپتین شد (P≤0.05). تزریق توام SHU9119 + لپتین،MCL0020 + لپتین، لپتین + astressin-B و astressin2-B + لپتین موجب مهار اثرات هیپوفاژیک ناشی از لپتین شد (P≤0.05). نتایج نشان دهنده این بود که هیپوفاژی ناشی از لپتین در تقابل با سیستم‌های ملانوکورتینی و هیستامینرژیک در جوجه‌های تخمگذار است.
کلیدواژه‌ها [English]
سیستم ملانوکورتینی, هیستامین, لپتین, اخذ غذا, جوجه تخمگذار
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آمار
تعداد مشاهده مقاله: 25
تعداد دریافت فایل اصل مقاله: 18


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