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Flavonoids, Phenolics and Acetylcholinesterase Inhibitory Potential of Different Solvent Extracts of some Medicinal Plants used as Brain Tonics: A Comparative Study | ||
| Journal of Medicinal plants and By-product | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 07 دی 1400 اصل مقاله (1.14 MB) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2021.355098.1374 | ||
| نویسندگان | ||
Samra Ihsan   ؛ Dildar Ahmed ؛ Hira Khalid
| ||
| Department of Chemistry, Forman Christian College (A Chartered University), Lahore 54000, Pakistan | ||
| چکیده | ||
| Alzheimer’s disease (AD) is a common old-age ailment characterized by the loss of memory and impairment of cognitive abilities and associated with an overexpression of cholinesterase enzymes. Quest for effective, safe and affordable inhibitors of these enzymes is thus required. The present project was designed to explore natural bioactive compounds with the ability to act as acetylcholinesterase (AChE) inhibitors. AChE inhibitory activity of methanolic (ME), ethyl acetate (EAE), acetonic (AE) and hydroethanolic (HEE) extracts of common medicinal plants used in brain tonics were estimated. Total phenolic and flavonoid contents of the extracts have also been determined. The plants studied included Borago officinalis, Salvia haematodes, Matthiola incana, Moringa oleifera, Lallemantia royleana, Lavandula stoechas, Centaurea behen and Coriandrum sativum. The MEs of all the selected plants showed the highest activity except M. oleifera and S. haematodes whose activity was slightly less than EAE of M. oleifera and AE of S. haematodes. EAEs of B. officinalis, M. oleifera and S. haematodes and AEs of B. officinalis and S. haematodes were also notable. A moderate correlation was found between TPC and AChE inhibitory activity of MEs and a moderately high correlation was found between TPC and AChE inhibitory activity of AEs of the selected plants. The acetylcholinesterase inhibition might play a role in the brain tonic effect of the selected plants. The activity may at least partly be rendered by the phenolic compounds present in the plants. | ||
| کلیدواژه‌ها | ||
| Medicinal plants؛ neurodegenerative disorders؛ bioactive compounds؛ correlation studies | ||
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آمار تعداد مشاهده مقاله: 4 تعداد دریافت فایل اصل مقاله: 20 |
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