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| تعداد نشریات | 279 |
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| تعداد مقالات | 26,072 |
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Evaluation of Antibacterial, Antibiofilm and Cytotoxicity Effect of Crude Ethanolic Extract of Cuminum cyminum Against Streptococcus mutans | ||
| Journal of Medicinal plants and By-product | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 04 دی 1400 اصل مقاله (545.91 K) | ||
| نوع مقاله: Research Paper | ||
| شناسه دیجیتال (DOI): 10.22092/jmpb.2021.356243.1412 | ||
| نویسندگان | ||
Elham Osanloo1؛ Ali Asghar Soleymani1؛ Marziyeh Taheri2؛ Sareh Sadat Hosseini2؛ Fatemeh Javadi1؛ Mohammadmahdi Karimi-Yazdi3؛ Majid Agha Gholizadeh1؛ Mojdeh Hakemi-Vala  2
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| 1Department of Pediatric Dentistry, School of Dentistry, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran | ||
| 2Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU) Tehran, Iran | ||
| 3Faculty of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran | ||
| چکیده | ||
| Although, oral health is important for its role in the overall health but oral health care does not have an integrated model. So, today meeting the needs of oral health requires strong interactions between health research policy and oral health researchThe aim of this study investigates the effects of ethanolic crud extract of Cuminum cyminum on S. mutans in terms of antibacterial, antibiofilm and, its cytotoxicity properties. The present experimental study which has conducted in 2019-2020. The crude alcoholic extract of Cuminum cyminum seeds was prepared by the maceration method. Then, the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of crude ethanolic extract of C. cyminum was determined by micro-dilution method according to CLSI protocol on Streptococcus mutans (PTCC1683). In addition, its antibiofilm effect was investigated by the previous method using crystal violet. As well, an MTT test was performed to evaluate its cytotoxicity on SW480 cells. Statistical analysis was done by SPSS V.22 software. MIC and MBC concentrations of C. cyminum extract on S. mutans were found to be 0.62 mg/mL and 1.25 mg/mL. The effect of inhibiting biofilm production was also observed at a concentration of 40 mg/mL. In MTT assay showed a greater cytotoxic effect on SW480 cancer cells at higher concentrations for longer periods of time. The present study showed that the cumin ethanolic crude extract has antimicrobial properties, inhibits the growth of S. mutans biofilms and has no toxic properties. | ||
| کلیدواژه‌ها | ||
| cumin؛ dental carriers؛ biofilm؛ S. mutans | ||
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آمار تعداد مشاهده مقاله: 30 تعداد دریافت فایل اصل مقاله: 11 |
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