اخبار و اعلانات

 آمار

تعداد نشریات286
تعداد نشریات سازمان84
تعداد شماره‌ها2,848
تعداد مقالات32,322
تعداد مشاهده مقاله41,444,836
تعداد دریافت فایل اصل مقاله18,644,933
Hassani, M. K. (1400). Role of Vitamin D as Protective Agent against Induced Liver Damage in Male Rats. سامانه مدیریت نشریات علمی, 76(6), 1815-1822. doi: 10.22092/ari.2021.356611.1881
M. K Hassani. "Role of Vitamin D as Protective Agent against Induced Liver Damage in Male Rats". سامانه مدیریت نشریات علمی, 76, 6, 1400, 1815-1822. doi: 10.22092/ari.2021.356611.1881
Hassani, M. K. (1400). 'Role of Vitamin D as Protective Agent against Induced Liver Damage in Male Rats', سامانه مدیریت نشریات علمی, 76(6), pp. 1815-1822. doi: 10.22092/ari.2021.356611.1881
Hassani, M. K. Role of Vitamin D as Protective Agent against Induced Liver Damage in Male Rats. سامانه مدیریت نشریات علمی, 1400; 76(6): 1815-1822. doi: 10.22092/ari.2021.356611.1881

Role of Vitamin D as Protective Agent against Induced Liver Damage in Male Rats

Archives of Razi Institute
مقاله 27، دوره 76، شماره 6، بهمن و اسفند 2021، صفحه 1815-1822    اصل مقاله (1.46 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356611.1881
نویسنده
M. K Hassani*
Department of Biology, College of Science, University of Misan, Maysan, Iraq
چکیده
One of the main factors which played a key role in the prevention of liver disorders such as hepatic inflammation, fibrosis, and carcinogenesis would be the vitamin D axis. Therefore, the current research was designed to evaluate the role of Vitamin D (Vit D)   as a protective agent against liver damage caused by Thioacetamide (TAA). In the current study, 18 male Wistar rats were randomly allocated into three equal groups (n=6): in group 1(G1) the animals were considered as the control group and did not receive any supplement in drinking water; in group 2 (G2) TAA was administrated to the drinking water at a dose of 300 mg/L; in group 3 (G3) TAA was administrated to the drinking water at a dose of 300 mg/L plus vitamin D at a dose of 0.5 mg/100g body (intraperitoneal) for 8 weeks. At the end of the experiment, the animals were sacrificed and the liver was dissected and removed for histopathology. Histopathological evaluations were used to evaluate the possible adverse effects of TAA on the liver. Several hepatic damages were observed in the G2 group such as lobular disorder, some degrees of degeneration in hepatocytes and enlargement of the hepatic capillaries, and focal necrotic areas. Hepatic fibrosis was observed around portal areas and central veins. Bridging fibrous septa were formed between portal veins. The recorded data in this study showed that Vit D has some beneficial effects in protecting the liver from fibrosis and toxic damages. The recorded data showed that liver damages in the G3 group were partially prevented or cured. In conclusion, it is evident that the Vit D played a pivotal role as an antioxidant and anti-fibrotic agent, therefore it would be the best supplement for liver protection against damages due to toxin entrance into the animal's body.
کلیدواژه‌ها
Vitamin D؛ Liver fibrosis؛ Thioacetamide؛ Histopathological examinations
سایر فایل های مرتبط با مقاله
مراجع
  1. Zargar S. Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats. Saudi J Biol Sci. 2014;21(2):139-45.
  2. Ichimura R, Mizukami S, Takahashi M, Taniai E, Kemmochi S, Mitsumori K, et al. Disruption of Smad-dependent signaling for growth of GST-P-positive lesions from the early stage in a rat two-stage hepatocarcinogenesis model. Toxicol Appl Pharmacol. 2010;246(3):128-40.
  3. JI PB, MM AH. Experimental thioacetamide-induced cirrhosis of the liver. Histol Histopathol. 1991;6(1):95-100.
  4. Chilakapati J, Shankar K, Korrapati MC, Hill RA, Mehendale HM. Saturation toxicokinetics of thioacetamide: role in initiation of liver injury. Drug Metab Dispos. 2005;33(12):1877-85.
  5. Natarajan SK, Thomas S, Ramamoorthy P, Basivireddy J, Pulimood AB, Ramachandran A, et al. Oxidative stress in the development of liver cirrhosis: a comparison of two different experimental models. J Gastroenterol Hepatol. 2006;21(6):947-57.
  6. F Holick M. Vitamin D: evolutionary, physiological and health perspectives. Curr Drug Targets. 2011;12(1):4-18.
  7. Izadi A, Aliasghari F, Gargari BP, Ebrahimi S. Strong association between serum vitamin D and vaspin levels, AIP, VAI and liver enzymes in NAFLD patients. Int J Vitam Nutr Res. 2020;90(1)59-66.
  8. Tavakoli H, Rostami H, Avan A, Bagherniya M, Ferns GA, Khayyatzadeh SS, et al. High dose vitamin D supplementation is associated with an improvement in serum markers of liver function. BioFactors. 2019;45(3):335-42.
  9. Borel P, Caillaud D, Cano N. Vitamin D bioavailability: state of the art. Crit Rev Food Sci Nutr. 2015;55(9):1193-205.
  10. Holick MF. Biological effects of sunlight, ultraviolet radiation, visible light, infrared radiation and vitamin D for health. Anticancer Res. 2016;36(3):1345-56.
  11. Farokhi F, Farkhad NK, Togmechi A. Preventive effects of Prangos ferulacea (L.) Lindle on liver damage of diabetic rats induced by alloxan. Avicenna J Phytomed. 2012;2(2):63.
  12. Aboonabi A, Rahmat A, Othman F. Effect of pomegranate on histopathology of liver and kidney on generated oxidative stress diabetic induced rats. J Cytol Histol. 2014;6(1):2-5.
  13. Ansil PN, Nitha A, Prabha SP, Wills PJ, Jazaira V, Latha MS. Protective effect of Amorphophallus campanulatus (Roxb.) Blume. tuber against thioacetamide induced oxidative stress in rats. Asian Pac J Trop Dis. 2011;4(11):870-7.
  14. Bruck R, Aeed H, Avni Y, Shirin H, Matas Z, Shahmurov M, et al. Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats. J Hepatol. 2004;40(1):86-93.
  15. Hajovsky H, Hu G, Koen Y, Sarma D, Cui W, Moore DS, et al. Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes. Chem Res Toxicol. 2012;25(9):1955-63.
  16. Jang J, Kang K, Kim Y, Kang Y, Lee I, editors. Reevaluation of experimental model of hepatic fibrosis induced by hepatotoxic drugs: an easy, applicable, and reproducible model. Transplant Proc; 2008: Elsevier.
  17. Strnad P, Tao GZ, Zhou Q, Harada M, Toivola DM, Brunt EM, et al. Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models. Gastroenterology. 2008;134(4):1169-79.
  18. Koen YM, Sarma D, Hajovsky H, Galeva NA, Williams TD, Staudinger JL, et al. Protein targets of thioacetamide metabolites in rat hepatocytes. Chem Res Toxicol. 2013;26(4):564-74.
  19. Abramovitch S, Dahan-Bachar L, Sharvit E, Weisman Y, Tov AB, Brazowski E, et al. Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. Gut. 2011;60(12):1728-37.
  20. Özerkan D, Özsoy N, Akbulut K, Güney Ş, Öztürk G. The protective effect of vitamin D against carbon tetrachloride damage to the rat liver. Biotech Histochem. 2017;92(7):513-23.
  21. Mokhtari Z, Hekmatdoost A, Nourian M. Antioxidant efficacy of vitamin D. J Parathyr Dis. 2016;5(1):11-6.
  22. Preedy VR. Diabetes: Oxidative stress and dietary antioxidants: Academic Press. 2020.
  23. Seif AA, Abdelwahed DM. Vitamin D ameliorates hepatic ischemic/reperfusion injury in rats. J Physiol Biochem. 2014;70(3):659-66.
  24. Adelani I, Ogadi E, Onuzulu C, Rotimi OA, Maduagwu E, Rotimi S. Dietary vitamin D ameliorates hepatic oxidative stress and inflammatory effects of diethylnitrosamine in rats. Heliyon. 2020;6(9):e04842.
  25. Ding N, Ruth TY, Subramaniam N, Sherman MH, Wilson C, Rao R, et al. A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response. Cell. 2013;153(3):601-13.
  26. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 2016;96(1):365-408.
  27. Elangovan H, Chahal S, Gunton JE. Vitamin D in liver disease: Current evidence and potential directions. Biochim Biophys Acta Mol Basis Dis. 2017;1863(4):907-16.
  1. Borges CC, Bringhenti I, Mandarim-de-Lacerda CA, Aguila MB. Vitamin D deficiency aggravates the liver metabolism and inflammation in ovariectomized mice. Biomed Pharmacother. 2018;107:878-88.
  2. Giammanco M, Di Majo D, La Guardia M, Aiello S, Crescimannno M, Flandina C, et al. Vitamin D in cancer chemoprevention. Pharm Biol. 2015;53(10):1399-434.
30.          Eliades M, Spyrou E. Vitamin D: a new player in non-alcoholic fatty liver disease? World J Gastroenterol. 2015;21(6):1718.

آمار
تعداد مشاهده مقاله: 13,603
تعداد دریافت فایل اصل مقاله: 291


counter
سامانه مدیریت نشریات علمی. قدرت گرفته از سیناوب