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Salah Najim, A, Bahry Al_Sadoon, M, Salem Sheet, M. (1401). Effect of Caraway Seed Extract on the Blood Biochemistry and Antioxidant Capacity among the Hyperoxidative Stress-Induced Rats. سامانه مدیریت نشریات علمی, 77(2), 553-563. doi: 10.22092/ari.2021.356810.1917
A Salah Najim; M Bahry Al_Sadoon; M Salem Sheet. "Effect of Caraway Seed Extract on the Blood Biochemistry and Antioxidant Capacity among the Hyperoxidative Stress-Induced Rats". سامانه مدیریت نشریات علمی, 77, 2, 1401, 553-563. doi: 10.22092/ari.2021.356810.1917
Salah Najim, A, Bahry Al_Sadoon, M, Salem Sheet, M. (1401). 'Effect of Caraway Seed Extract on the Blood Biochemistry and Antioxidant Capacity among the Hyperoxidative Stress-Induced Rats', سامانه مدیریت نشریات علمی, 77(2), pp. 553-563. doi: 10.22092/ari.2021.356810.1917
Salah Najim, A, Bahry Al_Sadoon, M, Salem Sheet, M. Effect of Caraway Seed Extract on the Blood Biochemistry and Antioxidant Capacity among the Hyperoxidative Stress-Induced Rats. سامانه مدیریت نشریات علمی, 1401; 77(2): 553-563. doi: 10.22092/ari.2021.356810.1917

Effect of Caraway Seed Extract on the Blood Biochemistry and Antioxidant Capacity among the Hyperoxidative Stress-Induced Rats

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مقاله 6، دوره 77، شماره 2، خرداد و تیر 2022، صفحه 553-563    اصل مقاله (1.2 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356810.1917
نویسندگان
A Salah Najim* 1؛ M Bahry Al_Sadoon2؛ M Salem Sheet1
1Department of Chemistry, Education College for Girls, Mosul University, Mosul, Iraq
2Department of Chemistry, College of Science, Mosul University, Mosul, Iraq
چکیده
Carum carvi (Carium) or caraway is traditionally used for the treatment of several metabolic and non-metabolic disorders. In the current study, extracted oil, flavonoids, and alkaloids from the Carium were used to evaluate the effects of these components on blood lipid profile and heart regeneration from oxidative damages caused by hydrogen peroxide consumption. A total of 50 male BALB/c mice were used in this study with a body weight of 23-32 g. The animals were randomly divided into 5 groups (n=10). Group 1: The animals in this group were considered the control group and fed with a normal diet. Group 2: Hyperoxidative stress was induced in this group by giving hydrogen peroxide at a concentration of 1% into the drinking water for 6 weeks. After this period, they did not receive any treatments and only received saline solution by intraperitoneal (IP) injection once a day for 4 weeks. Group 3: Hyperoxidative stress was induced by hydrogen peroxide at a concentration of 1% for 6 weeks. All the animals in this group received 1.25 mg/kg body weight (B.W.) extracted oil from Caraway seeds for 4 weeks by IP injection once a day each week. Group 4: Hyperoxidative stress was induced by hydrogen peroxide at a concentration of 1% for 6 weeks. All the animals in this group received 61.28 mg/kg B.W. extracted flavonoids from Caraway seeds for 4 weeks by IP injection once a day each week. Group 5: Hyperoxidative stress was induced by hydrogen peroxide at a concentration of 1% for 6 weeks. All the animals in this group received 7.8 mg/kg B.W. extracted alkaloids from Caraway seeds for 4 weeks by IP injection once a day each week. The levels of glutathione and malondialdehyde were estimated in the liver and kidneys in the animals with cardiovascular disorders induced by hydrogen peroxide at a concentration of 1%. The results of the current study showed that the alkaloids had the greatest effect in reducing harmful total cholesterol and a complete recovery of the heart and aorta from atherosclerotic lesions through viewing the tissue sections.
کلیدواژه‌ها
Cardiovascular disease؛ GC؛ Glutathione؛ High-density lipoprotein cholesterol؛ HPLC؛ Low-density lipoprotein cholesterol؛ Malondialdehyde؛ TG؛ Total cholesterol؛ Very low-density lipoprotein cholesterol
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مراجع
  1. Solikhah TI, Solikhah GP, Kuncoroningrat RJ. Aloe vera and Virgin Coconut Oil (VCO) accelerate healing process in domestic cat (Felis domesticus) suffering from scabies. Iraqi J Vet Sci. 2021;35(4):699-704.
  2. Johri R. Cuminum cyminum and Carum carvi: An update. Pharmacogn Rev. 2011;5(9):63.
  3. Aćimović M, Oljača S, Tešević V, Todosijević M, Đisalov J. Evaluation of caraway essential oil from different production areas of Serbia. Hortic Sci. 2014;41(3):122-30.
  4. Sachan AK, Das DR, Kumar M. Carum carvi-An important medicinal plant. J Chem Pharm Res. 2016;8(3):529-33.
  5. Attokaran M. Natural food flavors and colorants: John Wiley & Sons; 2017.
  6. Thippeswamy N, Naidu KA. Antioxidant potency of cumin varieties—cumin, black cumin and bitter cumin—on antioxidant systems. Eur Food Res Technol. 2005;220(5):472-6.
  7. Camele I, Elshafie HS, Caputo L, De Feo V. Anti-quorum sensing and antimicrobial effect of mediterranean plant essential oils against phytopathogenic bacteria. Front Microbiol. 2019;10:2619.
  8. Elshafie H, Caputo L, De Martino L, Gruľová D, Zheljazkov V, De Feo V, et al. Biological investigations of essential oils extracted from three Juniperus species and evaluation of their antimicrobial, antioxidant and cytotoxic activities. J Appl Microbiol. 2020;129(5):1261-71.
  9. Raut JS, Karuppayil SM. A status review on the medicinal properties of essential oils. Ind Crops Prod. 2014;62:250-64.
  10. Mahboubi M. Caraway as important medicinal plants in management of diseases. Nat Prod Bioprospec. 2019;9(1):1-11.
  11. AlSaad KM, Al-Autaish HN, Ahmed JA. Evaluation of cardiac enzymes and acute phase response as biomarkers for rapid diagnosis of myocarditis in calves with FMD. Iraqi J Vet Sci. 2020;34(1):31-7.
  12. Joint F. Fats and oils in human nutrition: report of a joint expert consultation. FAO Food and nutrition paper: FAO; 1994.
  13. Herrington W, Lacey B, Sherliker P, Armitage J, Lewington S. Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease. Circ Res. 2016;118(4):535-46.
  14. Libby P, Ridker PM, Hansson GK, Atherothrombosis LTNo. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009;54(23):2129-38.
  15. Robertson S, Miller MR. Ambient air pollution and thrombosis. Particle and fibre toxicology. 2018;15(1):1-16.
  16. Martín Giménez VM, Kassuha DE, Manucha W. Nanomedicine applied to cardiovascular diseases: latest developments. Ther Adv Cardiovasc Dis. 2017;11(4):133-42.
  17. Conklin DJ, Schick S, Blaha MJ, Carll A, DeFilippis A, Ganz P, et al. Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation. Am J Physiol Heart Circ Physiol. 2019;316(4):801-27.
  18. Al-Aalim AM, Hamad MA, AL-ledani AA. Some insights of novel COVID 19 virus: structure, pathogenicity and immunity aspects. Iraqi J Vet Sci. 2020;34(2):287-93.
  19. Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential effects of coronaviruses on the cardiovascular system: a review. JAMA Cardiol. 2020;5(7):831-40.
  20. Mohammed IH, Kakey ES. Effect of Prosopis farcta extracts on some complications (hematology and lipid profiles) associated with alloxan induced diabetic rats. Iraqi J Vet Sci. 2020;34(1):45-50.
  21. Kato H, Li W, Koike M, Wang Y, Koike K. Phenolic glycosides from Agrimonia pilosa. Phytochemistry. 2010;71(16):1925-9.
  22. Sezgin AC, Artik N. Determination of saponin content in Turkish tahini halvah by using HPLC. Adv J Food Sci Technol. 2010;2(2):109-15.
  23. Burtis CA, Ashwood ER, Bruns DE. Tietz textbook of clinical chemistry and molecular diagnostics-e-book: Elsevier Health Sciences; 2012.
  24. James RC, Goodman DR, Harbison RD. Hepatic glutathione and hepatotoxicity: changes induced by selected narcotics. J Pharmacol Exp Ther. 1982;221(3):708-14.
  1. Volken E, Nurperi G, Ahmet B. N-acetyl cystine reduces cerebral lipid peroxidation in a rat model of infantile hydrocephalus. J Neurol Sci. 2001:1302-10.
  2. Keppler AF, Gariani RA, Lopes DG, Comasseto JV. Lithium butylchalcogenolate induced Michael-aldol tandem sequence: easy and rapid access to highly functionalized organochalcogenides and unsaturated compounds. Tetrahedron Lett. 2009;50(19):2181-4.
  3. Abd Al-Zahra JI, Ismael DK, Al-Shawi NN. Preventive effects of different doses of pentoxyfilline against ccl4-induced liver toxicity in rats. Iraqi J Pharm Sci. 2009:39.
  4. Al-Malki AL. Antioxidant properties of thymol and butylated hydroxytoluene in carbon tetrachloride–induced mice liver injury. J KAU: Sci. 2010;22(1):239-48.
  5. Trivedi S, Lal N, Mahdi AA, Mittal M, Singh B, Pandey S. Evaluation of antioxidant enzymes activity and malondialdehyde levels in patients with chronic periodontitis and diabetes mellitus. J Periodontol. 2014;85(5):713-20.
  6. Paolicchi A, Emdin M, Ghliozeni E, Ciancia E, Passino C, Popoff G, et al. Human atherosclerotic plaques contain gamma-glutamyl transpeptidase enzyme activity. Circulation. 2004;109(11):1440-.
  7. Prieto A, Campos A, Cameán A, Vasconcelos V. Effects on growth and oxidative stress status of rice plants (Oryza sativa) exposed to two extracts of toxin-producing cyanobacteria (Aphanizomenon ovalisporum and Microcystis aeruginosa). Ecotoxicol Environ Saf. 2011;74(7):1973-80.
  8. MA Al-Saidya A. Study of pathological and anti-hyperlipidemic offects of ginger Zingiber officinalae in rats exposed to oxidative stress. Iraqi J Vet Sci. 2010;24(2):103-8.
  9. Mahmood DFD, Abderrazak A, El Hadri K, Simmet T, Rouis M. The thioredoxin system as a therapeutic target in human health and disease. Antioxid Redox Signal. 2013;19(11):1266-303.
  10. Cai L, Xiong X, Kong X, Xie J. The role of the lysyl oxidases in tissue repair and remodeling: a concise review. Tissue Eng Regen Med. 2017;14(1):15-30.
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