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Ali Imarah, A, Subhi Mohammed, M, Ahmed Najm, R, Al Zeyadi, M, Khayoon, S. Q, Alhamadani, I. (1400). Effect of the Concentration Levels of Growth Hormone and Insulin-like Growth Factor I on the Polymorphisms of the Il12p40 Gene in Lung Cancer Patients. سامانه مدیریت نشریات علمی, 77(1), 413-419. doi: 10.22092/ari.2021.356610.1880
A Ali Imarah; M Subhi Mohammed; R Ahmed Najm; M Al Zeyadi; S. Q Khayoon; I Alhamadani. "Effect of the Concentration Levels of Growth Hormone and Insulin-like Growth Factor I on the Polymorphisms of the Il12p40 Gene in Lung Cancer Patients". سامانه مدیریت نشریات علمی, 77, 1, 1400, 413-419. doi: 10.22092/ari.2021.356610.1880
Ali Imarah, A, Subhi Mohammed, M, Ahmed Najm, R, Al Zeyadi, M, Khayoon, S. Q, Alhamadani, I. (1400). 'Effect of the Concentration Levels of Growth Hormone and Insulin-like Growth Factor I on the Polymorphisms of the Il12p40 Gene in Lung Cancer Patients', سامانه مدیریت نشریات علمی, 77(1), pp. 413-419. doi: 10.22092/ari.2021.356610.1880
Ali Imarah, A, Subhi Mohammed, M, Ahmed Najm, R, Al Zeyadi, M, Khayoon, S. Q, Alhamadani, I. Effect of the Concentration Levels of Growth Hormone and Insulin-like Growth Factor I on the Polymorphisms of the Il12p40 Gene in Lung Cancer Patients. سامانه مدیریت نشریات علمی, 1400; 77(1): 413-419. doi: 10.22092/ari.2021.356610.1880

Effect of the Concentration Levels of Growth Hormone and Insulin-like Growth Factor I on the Polymorphisms of the Il12p40 Gene in Lung Cancer Patients

Archives of Razi Institute
مقاله 51، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 413-419    اصل مقاله (529.63 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356610.1880
نویسندگان
A Ali Imarah* 1؛ M Subhi Mohammed2؛ R Ahmed Najm2؛ M Al Zeyadi1؛ S. Q Khayoon1؛ I Alhamadani1
1Faculty of Sciences, University of Kufa, Kufa, Iraq
2Al-Furat Al-Awsat Technical University, Technical Institute, Kufa, Iraq
چکیده
The prevalence of lung cancer as one of the most common cancers with the highest mortality rate is one of the most important health problems in humans across the world. Molecular research can provide valuable information about genetic changes associated with the pathogenesis of the disease that may be used to improve prognosis and treatment. The current study aimed to examine the genotyping utility of the Il12p40 (IL-12B) gene (rs3212227, A>C) polymorphisms and detect its relationship with the concentration levels of HGH and IGF-1 for the non-small cell lung carcinoma (NSCLC). This study investigated 67 cases with NSCLC (60 males and 7 females) and 28 healthy individuals as controls. The serum level of HGH and IGF-1 was determined using an enzyme-linked immunosorbent assay. Genotyping of the IL-12B gene polymorphisms (rs3212227, A>C) was carried out by polymerase chain reaction-restriction fragment length polymorphism. The serum levels of the HGH and IGF-1 were estimated, and the results of the IL-12B genotyping showed an increased risk of NSCLC. The homozygous wild (AA) genotype of the IL-12 gene showed that the risk of NSCLC was higher than that of the heterozygous (AC) and homozygous genotypes (CC). Moreover, a significant elevation was found in the serum levels of the HGH in the NSCLC patients, compared to the control group. The result showed that the IL-12 gene polymorphism was implicated in the pathogenesis of the NSCLC and directed several metabolic changes.
کلیدواژه‌ها
Growth hormone؛ Insulin growth factor I؛ IL-12؛ Non-small cell lung carcinoma؛ Polymorphism
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مراجع
  1. Al Zeyadi M, Dimova I, Ranchich V, Rukova B, Nesheva D, Hamude Z, et al. Whole genome microarray analysis in non-small cell lung cancer. Biotechnol Biotechnol Equip. 2015;29(1):111-8.
  2. Al-Zeyade M. Tissue Microarray Analysis of EGFR Copy Number Changes In Lung Cancer. Msc degree Sofia University-Faculty of biology. 2008.
  3. Rom WN, Tchou-Wong K-M. Molecular and genetic aspects of lung cancer. Lung Cancer. 2003:3-26.
  4. Al Zeyadi MM. Molecular and genetic aspects of lung cancer. Biotechnol Biotechnol Equip. 2013;27(5):4051-60.
  5. Alzeyadi M, Rabeea H, editors. Microsatellite instability detectable for Lung cancer Prognosis. Journal of Physics: Conference Series; 2019: IOP Publishing.
  6. Cocco C, Di Carlo E, Zupo S, Canale S, Zorzoli A, Ribatti D, et al. Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo. Leukemia. 2012;26(6):1365-74.
  7. Menachem-Zidon OB, Avital A, Ben-Menahem Y, Goshen I, Kreisel T, Shmueli EM, et al. Astrocytes support hippocampal-dependent memory and long-term potentiation via interleukin-1 signaling. Brain Behav Immun. 2011;25(5):1008-16.
  8. Lyakh L, Trinchieri G, Provezza L, Carra G, Gerosa F. Regulation of interleukin‐12/interleukin‐23 production and the T‐helper 17 response in humans. Immunol Rev. 2008;226(1):112-31.
  9. Cao H, Wang G, Meng L, Shen H, Feng Z, Liu Q, et al. Association between circulating levels of IGF-1 and IGFBP-3 and lung cancer risk: a meta-analysis. PloS One. 2012;7(11):e49884.
  10. Glocker E-O, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009;361(21):2033-45.
  11. Hussell T, Isaacson PG, Spencer J, Crabtree J. The response of cells from low-grade B-cell gastric lymphomas of mucosa-associated lymphoid tissue to Helicobacter pylori. Lancet. 1993;342(8871):571-4.
  12. Chien C-H, Lee M-J, Liou H-C, Liou H-H, Fu W-M. Growth hormone is increased in the lungs and enhances experimental lung metastasis of melanoma in DJ-1 KO mice. BMC Cancer. 2016;16(1):1-12.
  13. Morgillo F, Kim W-Y, Kim ES, Ciardiello F, Hong WK, Lee H-Y. Implication of the insulin-like growth factor-IR pathway in the resistance of non–small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007;13(9):2795-803.
  14. Shanmugalingam T, Bosco C, Ridley AJ, Van Hemelrijck M. Is there a role for IGF‐1 in the development of second primary cancers? Cancer Med. 2016;5(11):3353-67.
  15. REITER EO, MORRIS AH, MACGILLIVRAY MH, WEBER D. Variable estimates of serum growth hormone concentrations by different radioassay systems. J Clin Endocrinol Metab. 1988;66(1):68-71.
  1. Jafarzadeh A, Minaee K, Farsinejad A-R, Nemati M, Khosravimashizi A, Daneshvar H, et al. Evaluation of the circulating levels of IL-12 and IL-33 in patients with breast cancer: influences of the tumor stages and cytokine gene polymorphisms. Iran J Basic Med Sci. 2015;18(12):1189.
  2. Guler H-P, Zapf J, Froesch ER. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med. 1987;317(3):137-40.
  3. Han J-Y, Choi BG, Choi JY, Lee SY, Ju SY. The prognostic significance of pretreatment plasma levels of insulin-like growth factor (IGF)-1, IGF-2, and IGF binding protein-3 in patients with advanced non-small cell lung cancer. Lung Cancer. 2006;54(2):227-34.
  4. Delafontaine P, Song Y-H, Li Y. Expression, regulation, and function of IGF-1, IGF-1R, and IGF-1 binding proteins in blood vessels. Arterioscler Thromb Vasc Biol. 2004;24(3):435-44.
  5. Liu J, Chen Q, Wang B. Analysis on the effect of serum CA211 and IGF-1 expression in postoperative clinical efficacy of non-small cell lung cancer. Biomed Res. 2017;28(14).
  6. Wang Z, Wang Z, Liang Z, Liu J, Shi W, Bai P, et al. Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer. Onco Targets Ther. 2013;6:1437.
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