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Haramipour, P, Asghari, A, Hassanpour, Sh, Jahandideh, A. (1400). Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice. سامانه مدیریت نشریات علمی, 76(5), 1407-1417. doi: 10.22092/ari.2020.352221.1553
P Haramipour; A Asghari; Sh Hassanpour; A Jahandideh. "Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice". سامانه مدیریت نشریات علمی, 76, 5, 1400, 1407-1417. doi: 10.22092/ari.2020.352221.1553
Haramipour, P, Asghari, A, Hassanpour, Sh, Jahandideh, A. (1400). 'Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice', سامانه مدیریت نشریات علمی, 76(5), pp. 1407-1417. doi: 10.22092/ari.2020.352221.1553
Haramipour, P, Asghari, A, Hassanpour, Sh, Jahandideh, A. Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice. سامانه مدیریت نشریات علمی, 1400; 76(5): 1407-1417. doi: 10.22092/ari.2020.352221.1553

Anti-depressant Effect of Betaine Mediates via Nitrergic and Serotoninergic Systems in Ovariectomized Mice

Archives of Razi Institute
مقاله 30، دوره 76، شماره 5، بهمن و اسفند 2021، صفحه 1407-1417    اصل مقاله (1.07 M)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2020.352221.1553
نویسندگان
P Haramipour1؛ A Asghari2؛ Sh Hassanpour* 3؛ A Jahandideh2
1Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
2Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
3Division of Physiology, Department of Basic Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran
چکیده
This study aimed to determine the anti-depressant effect of betaine (BT) in ovariectomized mice and its possible interaction with nitrergic and serotoninergic systems. In experiment 1, the mice were divided into control and sham groups, ovariectomy (OVX), OVX+BT (12.5mg/kg), OVX+BT (25 mg/kg), and OVX+BT (50mg/kg) groups. In experiment 2, the mice were assigned into control and sham, OVX, OVX+BT (50mg/kg), OVX+L-NAME (10 mg/kg), as well as OVX+injection of the BT and L-NAME. Experiments 3-5 were similar to experiment 2, except for L-Arginine (50 mg/kg), Fluoxetine (5 mg/kg), and Cyproheptadine (4 mg/kg) that were injected instead of the L-NAME. Subsequently, forced swimming test (FST), tail suspension test (TST), and open field test (OFT) were performed in this study. Moreover, this study determined serum Malondialdehyde (MDA), Superoxide dismutase (SOD), Glutathione peroxidase (GPx), and total antioxidant status levels. According to the findings, OVX increased immobility time, compared to the control group (P<0.05). In addition, BT (50mg/kg) decreased depression-induced immobility time, compared to the OVX group (P<0.05). The co-injection of the BT+L-NAME decreased depression-induced immobility time in TST and FST, followed by an increase in the number of crossing in OFT(P<0.05).Moreover, the co-injection of the BT+L-Arginine significantly diminished the antidepressant activity of BT on immobility time and decreased positive effect of BT on the number of crossing (P<0.05). The co-injection of the BT+Fluoxetine significantly amplified the antidepressant activity of BT on immobility time and number of crossing (P<0.05). Furthermore, the co-injection of the BT+Cyproheptadine decreased antidepressant activity of BT on immobility time and number of crossing (P<0.05). The BT (25 and 50mg/kg) reduced the MDA; however, it elevated SOD and GPx levels in OVX mice (P<0.05). It seems that antidepressant activity of BT mediates via nitrergic and serotoninergic systems in OVX mice.
کلیدواژه‌ها
Anti-depressant؛ Betaine؛ Serotoninergic؛ Nitrergic؛ Ovariectomy؛ Mice
عنوان مقاله [English]
Anti-depressant effect of Betaine mediates via nitrergic and serotoninergic systems in ovariectomized mice
چکیده [English]
The aim of current study was to determine anti-depressant effect of betaine(BT) in ovariectomized mice and its possible interaction with nitrergic and serotoninergic systems. In experiment 1, mice kept as control and sham groups, ovariectomized(OVX), OVX+BT (12.5mg/kg), OVX+BT(25mg/kg) and OVX+BT(50mg/kg). In experiment 2, mice kept as control and sham, OVX, OVX+BT(50mg/kg), OVX+L-NAME(10mg/kg) and OVX+-injection of the BT and L-NAME. Experiments 3-5 were similar to experiment 2, except L-Arginine (50mg/kg), Fluoxetine(5mg/kg) and Cyproheptadine (4mg/kg) were injected instead of the L-NAME. Then forced swimming test(FST), tail suspension test(TST) and open field test(OFT) tests were done. Also, serum Malondialdehyde(MDA), Superoxide dismutase(SOD), Glutathione peroxidase(GPx) and total antioxidant status(TAS) levels were determined. According to the findings, OVX increased immobility time compared to control group (P<0.05). BT (50mg/kg) decreased depression induced immobility time compared to OVX group (P<0.05). Co-injection of the BT+ L-NAME decreased depression induced immobility time in TST and FST and increased number of crossing in OFT (P<0.05). Co-injection of the BT+L-Arginine significantly diminished antidepressant activity of the BT on immobility time and decreased positive effect of the BT on number of crossing (P<0.05). Co-injection of the BT+fluoxetine significantly amplified antidepressant activity of the BT on immobility time and number of crossing (P<0.05). Co-injection of the BT+ cyproheptadine decreased antidepressant activity of the BT on immobility time and number of crossing (P<0.05). BT (25 and 50mg/kg) reduced the MDA while elevated SOD and GPx levels in OVX mice (P<0.05). It seems, antidepressant activity of the BT mediates via nitrergic and serotoninergic system in OVX mice.
کلیدواژه‌ها [English]
Anti-depressant, Betaine, Ovariectomy, Mice
سایر فایل های مرتبط با مقاله
مراجع
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