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Kadhem Mallakh, M, Mohammed Mahmood, M, Hasan Mohammed Ali, S. (1400). Immunomolecular Investigation of Human Papillomavirus Genotypes (16, 18) and P63 Expression in Patients with Malignant and Non-malignant Colorectal Tumors. سامانه مدیریت نشریات علمی, 77(1), 383-390. doi: 10.22092/ari.2021.356608.1879
M Kadhem Mallakh; M Mohammed Mahmood; S Hasan Mohammed Ali. "Immunomolecular Investigation of Human Papillomavirus Genotypes (16, 18) and P63 Expression in Patients with Malignant and Non-malignant Colorectal Tumors". سامانه مدیریت نشریات علمی, 77, 1, 1400, 383-390. doi: 10.22092/ari.2021.356608.1879
Kadhem Mallakh, M, Mohammed Mahmood, M, Hasan Mohammed Ali, S. (1400). 'Immunomolecular Investigation of Human Papillomavirus Genotypes (16, 18) and P63 Expression in Patients with Malignant and Non-malignant Colorectal Tumors', سامانه مدیریت نشریات علمی, 77(1), pp. 383-390. doi: 10.22092/ari.2021.356608.1879
Kadhem Mallakh, M, Mohammed Mahmood, M, Hasan Mohammed Ali, S. Immunomolecular Investigation of Human Papillomavirus Genotypes (16, 18) and P63 Expression in Patients with Malignant and Non-malignant Colorectal Tumors. سامانه مدیریت نشریات علمی, 1400; 77(1): 383-390. doi: 10.22092/ari.2021.356608.1879

Immunomolecular Investigation of Human Papillomavirus Genotypes (16, 18) and P63 Expression in Patients with Malignant and Non-malignant Colorectal Tumors

Archives of Razi Institute
مقاله 48، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 383-390    اصل مقاله (443.02 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356608.1879
نویسندگان
M Kadhem Mallakh* 1؛ M Mohammed Mahmood2؛ S Hasan Mohammed Ali3
1Department of Medical Laboratory Techniques, Ashur University College, Baghdad, Iraq
2Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
3Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad, Baghdad, Iraq
چکیده
Cancer of the colon (colorectal cancer, or CRC) is the third most frequent malignancy in the world and the fourth leading cause of cancer-related death. Recent research has focused on the link between high-risk human papillomavirus (HPV) infections and the onset/development of several different types of cancer in humans. As a result, scientists are now paying more attention to HPV and CRC. In a variety of malignant tumors, P63 is overexpressed. This includes non-Hodgkin lymphoma and breast carcinoma, as well as lung, bladder, and prostate cancers. However, in accordance with the existence of many P63 isoforms in malignant tumors, the actions of P63 in these malignancies remain a source of debate. P63 immunohistochemistry expression in CRC tissues is being investigated as a possible etiological link between high-risk HPV types and CRC. This retrospective study intended to investigate if there was an etiological link between high-risk HPV types and CRC. It has utilized 92 chosen formalin-fixed and paraffin-embedded tissue block samples. The collected samples were divided into 62 blocks of colorectal adenocarcinoma mass tissues and 30 non-malignant colorectal tissues used as a control group. Chromogenic in situ hybridization (CISH) was employed to discover HPV DNA16/18 in colorectal tissues. The overall proportion of positive HPV16/18 DNA- CISH detection in the mass CRC group was 44.4%, whereas HPV16/18 DNA was obtained at 80.0% in the non-malignant control group. The overall proportion of positive P63-ISH detection in the CRC group was also 70.4%, whereas P63 was 73.3% in the non-malignant control group. The link between HPV infection and P63 expression in CRC might point to the importance of these molecules in the progression of CRC.
کلیدواژه‌ها
Chromogenic in situ hybridization؛ Colorectal cancer؛ HPV؛ P63
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مراجع
  1. Organization WH. Colorectal cancer Source: Globocan 2018 Number of new cases in 2018, both sexes, all ages [Internet]. 2018.[cited 30 May 2019].
  2. Ferlay J, Shin H, Bray F, Forman D, Mathers C, Parkin D. GLOBOCAN 2008, Cancer incidence and mortality worldwide: IARC CancerBase No. 10. Lyon, France: International Agency for Research on Cancer. 2008.
  3. Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA, et al. Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer. 2004;101(2):270-80.
  1. Ferreira AR, Ramalho AC, Marques M, Ribeiro D. The interplay between antiviral signalling and carcinogenesis in human papillomavirus infections. Cancers. 2020;12(3):646.
  2. Van Dyne EA, Henley SJ, Saraiya M, Thomas CC, Markowitz LE, Benard VB. Trends in human papillomavirus–associated cancers—United States, 1999–2015. Morb Mortal Wkly Rep. 2018;67(33):918.
  3. Dooley KE, Warburton A, McBride AA. Tandemly integrated HPV16 can form a Brd4-dependent super-enhancer-like element that drives transcription of viral oncogenes. MBio. 2016;7(5):01446-16.
  4. Bernabe-Dones RD, Gonzalez-Pons M, Villar-Prados A, Lacourt-Ventura M, Rodríguez-Arroyo H, Fonseca-Williams S, et al. High prevalence of human papillomavirus in colorectal cancer in Hispanics: a case-control study. Gastroenterol Res Pract. 2016;2016.
  5. Burnett-Hartman AN, Newcomb PA, Mandelson MT, Galloway DA, Madeleine MM, Wurscher MA, et al. No evidence for human papillomavirus in the etiology of colorectal polyps. Cancer Epidemiol Biomark Prev. 2011;20(10):2288-97.
  6. Damin DdC, Caetano MB, Rosito MA, Schwartsmann G, Damin A, Frazzon A, et al. Evidence for an association of human papillomavirus infection and colorectal cancer. Eur J Surg Oncol. 2007;33(5):569-74.
  7. Fisher ML, Balinth S, Mills AA. p63-related signaling at a glance. J Cell Sci. 2020;133(17):jcs228015.
  8. Yang A, Kaghad M, Wang Y, Gillett E, Fleming MD, Dötsch V, et al. p63, a p53 homolog at 3q27–29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell. 1998;2(3):305-16.
  9. Gudlaugsson E, Skaland I, Undersrud E, Janssen EA, Søiland H, Baak JP. D2-40/p63 defined lymph vessel invasion has additional prognostic value in highly proliferating operable node negative breast cancer patients. Mod Pathol. 2011;24(4):502-11.
  10. Iacono ML, Monica V, Saviozzi S, Ceppi P, Bracco E, Papotti M, et al. p63 and p73 isoform expression in non-small cell lung cancer and corresponding morphological normal lung tissue. J Thorac Oncol. 2011;6(3):473-81.
  11. Karni-Schmidt O, Castillo-Martin M, HuaiShen T, Gladoun N, Domingo-Domenech J, Sanchez-Carbayo M, et al. Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. Am J Pathol. 2011;178(3):1350-60.
  1. Parsons JK, Saria EA, Nakayama M, Vessella RL, Sawyers CL, Isaacs WB, et al. Comprehensive mutational analysis and mRNA isoform quantification of TP63 in normal and neoplastic human prostate cells. Prostate. 2009;69(5):559-69.
  2. Kalebi A, Hale M. p63 expression in ovarian tumours: immunopositivity in metastatic transitional cell carcinoma of the ovary. Histopathology. 2008;53(2):228.
  3. Neto AH, Siqueira S, Dulley F, Ruiz M, Chamone D, Pereira J. p63 protein expression in high risk diffuse large B-cell lymphoma. J Clin Pathol. 2009;62(1):77-9.
  4. Burnett-Hartman AN, Newcomb PA, Potter JD. Infectious agents and colorectal cancer: a review of Helicobacter pylori, Streptococcus bovis, JC virus, and human papillomavirus. Cancer Epidemiol Biomarkers Prev. 2008;17(11):2970-9.
  5. Rosa MI, Silva GD, de Azedo Simões PWT, Souza MV, Panatto APR, Simon CS, et al. The prevalence of human papillomavirus in ovarian cancer: a systematic review. Int J Gynecol Cancer. 2013;23(3).
  6. Khalil KH, Al-Hassawi BA, Abdo JM. Correlation of Neuroendocrine Differentiation with Neuroendocrine Cell Hyperplasia and Vascular Endothelial Growth Factor in Colorectal Adenocarcinoma. Baghdad Sci J. 2021;18(1):0018-.
  7. McGregor B, Byrne P, Kirgan D, Albright J, Manalo P, Hall M. Confirmation of the association of human papillomavirus with human colon cancer. Am J Surg. 1993;166(6):738-42.
  8. Młynarczyk B, Malejczyk M, Muszyński J, Majewski S. The occurrence of human papillomavirus--HPV in the biopsies from colon polyps and cancer. Med Dosw Mikrobiol. 2009;61(2):191-6.
  9. Mlynarczyk-Bonikowska B, Muszyński J, Szymanek-Mjchrzak K, Ziółowski B, Mlynarczyk G, Malejczyk M, et al. The prevalence of human papillomaviruses in patients with colon polyps. Med Dosw Mikrobiol. 2017;69(1):49-54.
  10. Bodaghi S, Yamanegi K, Xiao S-Y, Da Costa M, Palefsky JM, Zheng Z-M. Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res. 2005;11(8):2862-7.
  1. Cheng J, Sheu L, Meng C, Lee W, Lin J. Detection of human papillomavirus DNA in colorectal carcinomas by polymerase chain reaction. Gut. 1995;37(1):87-90.
  2. Ghabreau L, Segal ED, Yasmeen A, Kassab A, Akil N, Al Moustafa A-E. High-risk human papillomavirus infections in colorectal cancer in the Syrian population and their association with Fascin, Id-1 and P-cadherin expressions: A tissue microarray study. Clin Cancer Invest J. 2012;1(1):26.
  3. Sun Z-Q, Wang H-J, Zhao Z-L, Wang Q-S, Fan C-W, Kureshi K, et al. Significance of HPV infection and genic mutation of APC and K-ras in patients with rectal cancer. Asian Pac J Cancer Prev. 2013;14(1):121-6.
  4. Picanço-Junior OM, Oliveira ALT, Freire LTM, Brito RB, Villa LL, Matos D. Association between human Papillomavirus and colorectal adenocarcinoma and its influence on tumor staging and degree of cell differentiation. Arq Bras Cir Dig. 2014;27:172-6.
  5. Carneiro FP, Ramalho LNZ, Britto-Garcia S, Ribeiro-Silva A, Zucoloto S. Immunohistochemical expression of p16, p53, and p63 in colorectal adenomas and adenocarcinomas. Dis Colon Rectum. 2006;49(5):588-94.
  6. Guo H-Q, Huang G-L, Liu O-F, Liu Y-Y, Yao Z-H, Yao S-N, et al. p63 Expression is a prognostic factor in colorectal cancer. Int J Biol Markers. 2012;27(3):212-8.
  7. Bahnassy AA, Zekri A-RN, Salem SE, Abou-Bakr AA, Sakr MA, Abdel-Samiaa AG, et al. Differential expression of p53 family proteins in colorectal adenomas and carcinomas: Prognostic and predictive values. Histol Histopathol. 2014.
  8. Albasri AM, Elkablawy MA, Ansari IA, Alhujaily AS, Khalil AA. The prognostic significance of p63 cytoplasmic expression in colorectal cancer: An immunohistochemical study. Saudi Med J. 2019;40(5):432.
  9. Shirendeb U, Hishikawa Y, Moriyama S, Win N, Thu MMM, Mar KS, et al. Human papillomavirus infection and its possible correlation with p63 expression in cervical cancer in Japan, Mongolia, and Myanmar. Acta Histochem Cytochem. 2009;42(6):181-90.
  10. Citro S, Bellini A, Medda A, Sabatini ME, Tagliabue M, Chu F, et al. Human Papilloma Virus Increases ΔNp63α Expression in Head and Neck Squamous Cell Carcinoma. Front Cell Infect Microbiol. 2020;10:143.
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