اخبار و اعلانات

 آمار

تعداد نشریات284
تعداد نشریات سازمان82
تعداد شماره‌ها3,074
تعداد مقالات34,301
تعداد مشاهده مقاله47,138,223
تعداد دریافت فایل اصل مقاله78,044,032
Muqdamal, Ali, Abdulhameed, A, Ali Mansour, A. (1400). Total Testosterone to Estradiol Ratio as a Predictor Marker of Metabolic Syndrome in Males. سامانه مدیریت نشریات علمی, 77(1), 351-357. doi: 10.22092/ari.2021.356607.1878
Ali Hamza Muqdamal; A Abdulhameed; A Ali Mansour. "Total Testosterone to Estradiol Ratio as a Predictor Marker of Metabolic Syndrome in Males". سامانه مدیریت نشریات علمی, 77, 1, 1400, 351-357. doi: 10.22092/ari.2021.356607.1878
Muqdamal, Ali, Abdulhameed, A, Ali Mansour, A. (1400). 'Total Testosterone to Estradiol Ratio as a Predictor Marker of Metabolic Syndrome in Males', سامانه مدیریت نشریات علمی, 77(1), pp. 351-357. doi: 10.22092/ari.2021.356607.1878
Muqdamal, Ali, Abdulhameed, A, Ali Mansour, A. Total Testosterone to Estradiol Ratio as a Predictor Marker of Metabolic Syndrome in Males. سامانه مدیریت نشریات علمی, 1400; 77(1): 351-357. doi: 10.22092/ari.2021.356607.1878

Total Testosterone to Estradiol Ratio as a Predictor Marker of Metabolic Syndrome in Males

Archives of Razi Institute
مقاله 44، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 351-357    اصل مقاله (517.94 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356607.1878
نویسندگان
Ali Hamza Muqdamal* 1؛ A Abdulhameed2؛ A Ali Mansour1
1Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC), University of Basrah, Basrah, Iraq
2College of Medicine, University of Basrah, Basrah, Iraq
چکیده
Nowadays, metabolic syndrome (MetS) represents a global health challenge in developed and developing countries. The sex hormones disorders in males are related to many clinical co-morbidities. This study aimed to evaluate the total testosterone (TT) to estradiol (E2) ratio as a predictor marker of MetS. This case-control study included 88 MetS patients and 88 healthy individuals (control), in the age range of 18-69 years who were selected among patients who were referring to an outpatient clinic, using a convenience sampling method. The study participants were selected based on their medical history and physical examination, which included waist circumference, blood pressure, serum E2, TT, fasting blood glucose (FBG), triglyceride (TG), and high-density lipoprotein-cholesterol (HDL-C). Diagnosis of MetS was confirmed according to the National Cholesterol Education Program Adult Treatment Panel III guidelines. The findings revealed that the mean TT level was significantly lower among patients with MetS (P<0.001), while the mean E2 level was significantly higher among patients with MetS (P<0.001). The mean TT to E2 ratio was significantly lower among patients with MetS (OR=9.6, P<0.001). There was a significant correlation between MetS components and TT to E2 ratio and waist circumference (WC) (r = - 0.49, P<0.0001). The means of weight, WC, blood pressure, and FBG levels were significantly higher in patients with MetS (P<0.001, P<0.001, P<0.001, P=0.04, respectively), and the lipid profile of patients with MetS was abnormal (TG, P<0.001, HDL-C, P<0.001). Eventually, it can be concluded that the TT to E2 ratio can be regarded as a significant predictor of MetS in males.
کلیدواژه‌ها
Estradiol؛ Iraq؛ Metabolic syndrome؛ Testosterone
سایر فایل های مرتبط با مقاله
مراجع
  1. Kassi E, Pervanidou P, Kaltsas G, Chrousos G. Metabolic syndrome: definitions and controversies. BMC Med. 2011;9(1):1-13.
  2. Parikh RM, Mohan V. Changing definitions of metabolic syndrome. Indian J Endocrinol Metab. 2012;16(1):7.
  3. Sliem HA, Ahmed S, Nemr N, El-Sherif I. Metabolic syndrome in the Middle East. Indian J Endocrinol Metab. 2012;16(1):67.
  4. Al-Azzawi OF. Metabolic syndrome; comparing the results of three definition criteria in an Iraqi sample. AL-Kindy College Medical Journal. 2018;14(2):7-12.
  5. Saleh AA, Hayawi AH, Al-Samarrai AY, Lafta RK. Metabolic syndrome among obese adults in Baghdad, Iraq. Saudi J Obesity. 2017;5(1):8.
  6. Maggio M, Ceda GP, Lauretani F, Bandinelli S, Metter EJ, Artoni A, et al. Estradiol and inflammatory markers in older men. J Clin Endocrinol Metab. 2009;94(2):518-22.
  7. Goodpaster BH, Krishnaswami S, Harris TB, Katsiaras A, Kritchevsky SB, Simonsick EM, et al. Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med. 2005;165(7):777-83.
  8. Kupelian V, Page ST, Araujo AB, Travison TG, Bremner WJ, McKinlay JB. Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men. J Clin Endocrinol Metab. 2006;91(3):843-50.
  9. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the international diabetes federation task force on epidemiology and prevention; national heart, lung, and blood institute; American heart association; world heart federation; international atherosclerosis society; and international association for the study of obesity. Circulation. 2009;120(16):1640-5.
  10. Bekaert M, Van Nieuwenhove Y, Calders P, Cuvelier CA, Batens A-H, Kaufman J-M, et al. Determinants of testosterone levels in human male obesity. Endocrine. 2015;50(1):202-11.
  11. Hevener AL, Clegg DJ, Mauvais-Jarvis F. Impaired estrogen receptor action in the pathogenesis of the metabolic syndrome. Mol Cell Endocrinol. 2015;418:306-21.
  12. Alajeely MHJ, Abdulkareem DT, Ghazzay HI, Jasim E. Association between serum testosterone-estradiol ratio and body mass index in obese iraqi men. Ann Trop Med Public Health. 2020;23:23-1028.
  13. Kusuma R, Siregar Y, editors. Estradiol to testosterone ratio in metabolic syndrome men aged started 40 years above. IOP Conference Series: Earth and Environmental Science; 2018: IOP Publishing.
  14. Antonio L, Wu FC, O'Neill TW, Pye SR, Carter EL, Finn JD, et al. Associations between sex steroids and the development of metabolic syndrome: a longitudinal study in European men. J Clin Endocrinol Metab. 2015;100(4):1396-404.
  15. Bhasin S, Jasjua GK, Pencina M, D’Agostino R, Coviello AD, Vasan RS, et al. Sex hormone–binding globulin, but not testosterone, is associated prospectively and independently with incident metabolic syndrome in men: the Framingham heart study. Diabetes care. 2011;34(11):2464-70.
  16. Haring R, Völzke H, Spielhagen C, Nauck M, Wallaschofski H. The role of sex hormone-binding globulin and testosterone in the risk of incident metabolic syndrome. Eur J Prev Cardiol. 2013;20(6):1061-8.
  17. Li C, Ford ES, Li B, Giles WH, Liu S. Association of testosterone and sex hormone–binding globulin with metabolic syndrome and insulin resistance in men. Diabetes care. 2010;33(7):1618-24.
  18. Muraleedharan V, Jones TH. Testosterone and the metabolic syndrome. Therapeutic Advances in Endocrinology and Metabolism. 2010;1(5):207-23.
  19. Ross R, Neeland IJ, Yamashita S, Shai I, Seidell J, Magni P, et al. Waist circumference as a vital sign in clinical practice: a Consensus Statement from the IAS and ICCR Working Group on Visceral Obesity. Nat Rev Endocrinol. 2020;16(3):177-89.
  1. Kurotani K, Miyamoto T, Kochi T, Eguchi M, Imai T, Nishihara A, et al. Metabolic syndrome components and diabetes incidence according to the presence or absence of impaired fasting glucose: The Japan Epidemiology Collaboration on Occupational Health Study. J Epidemiol. 2017;27(9):408-12.
  2. Zidek W, Naditch-Brûlé L, Perlini S, Farsang C, Kjeldsen SE. Blood pressure control and components of the metabolic syndrome: the GOOD survey. Cardiovasc Diabetol. 2009;8(1):1-9.
  3. Tao L-X, Yang K, Liu X-T, Cao K, Zhu H-P, Luo Y-X, et al. Longitudinal associations between triglycerides and metabolic syndrome components in a Beijing adult population, 2007-2012. Int J Med Sci. 2016;13(6):445.
  4. Mani P, Ren H-Y, Neeland IJ, McGuire DK, Ayers CR, Khera A, et al. The association between HDL particle concentration and incident metabolic syndrome in the multi-ethnic Dallas Heart Study. Diabetes Metab Syndr. 2017;11(1):S175-S9.
  5. Rohrmann S, Shiels MS, Lopez DS, Rifai N, Nelson WG, Kanarek N, et al. Body fatness and sex steroid hormone concentrations in US men: results from NHANES III. Cancer Causes & Control. 2011;22(8):1141-51.
  6. Miranda EP, Oliveira C, Carvalho E, Rabelo A, Xavier A, Tiraboschi R, et al. MP91-08 Combination Of Metabolic Syndrome Components To Predict Testosterone Deficiency In Men. Urol J. 2017;197(4S): 1221.
  7. Ahmed IZ, Mahdy MM, El Oraby H, Abdelazeem EM. Association of sex hormones with metabolic syndrome among Egyptian males. Diabetes Metab Syndr. 2017;11:S1059-S64.
27.          Liu PJ, Lou HP, Zhu YN. Screening for metabolic syndrome using an integrated continuous index consisting of waist circumference and triglyceride: A preliminary cross-sectional study. Diabetes Metab Syndr Obes. 2020;13:2899.

آمار
تعداد مشاهده مقاله: 2,428
تعداد دریافت فایل اصل مقاله: 2,752


counter
سامانه مدیریت نشریات علمی. طراحی و پیاده سازی از سیناوب