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Clinical and Genetic characteristics of Preeclampsia | ||
| Archives of Razi Institute | ||
| مقالات آماده انتشار، پذیرفته شده، انتشار آنلاین از تاریخ 18 آبان 1400 | ||
| نوع مقاله: Original Articles | ||
| شناسه دیجیتال (DOI): 10.22092/ari.2021.356481.1852 | ||
| نویسندگان | ||
Oleg V. Golovchenko  ؛ Mariya Yu. Abramova؛ Valentina S. Orlova؛ Irina V. Batlutskaya؛ Inna N. Sorokina
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| Belgorod State University, 308015, Belgorod, Pobeda Street, 85, RUSSIA | ||
| چکیده | ||
| Preeclampsia (PE) is a severe complication of pregnancy that is accompanied by the development of arterial hypertension, edema or proteinuria with impaired functioning of various organs and systems. Preeclampsia is an important medical and social problem. It has long been one of the leading causes of maternal and perinatal mortality and morbidity worldwide. In the course of study examined the clinical characteristics of PE and studied the contribution of the polymorphic loci rs1042838 of the PGR gene and rs8068318 of the TBX2 gene to the development of PE. The sample included 219 women with PE (mean age 26.52 ± 5.51 years) and 329 women with physiological course of pregnancy included in the control group (mean age 26.27 ± 4.88 years). It found that 64.20% of women with PE had an increase in SBP, 68.29% had an increase in normal DBP values, 16.44% had proteinuria, 98.63% had edema, and 35.48% of cases had overweight (BMI = 25). In the control group, 100% of cases had normal SBP values and no proteinuria, 1.53% had their DBP 90 mm Hg, 1.12% developed edema, and 35.48% had overweight (BMI = 25). Women with PE were found to have an association of the CC genotype of the rs8068318 polymorphism of the TBX2 gene with the risk of preeclampsia (OR = 2.12, 95%CI 1.14-3.92, p = 0.02), as well as an association of the rs8068318 TBX2 polymorphic locus with lower SBP (Me = 140, Q25 – Q75 130 – 142.5, p = 0.01) and PBP (Me = 50, Q25 – Q75 40 – 55, p 0.01). According to the GeneCards data (http://www.genecards.org/), the TBX2 gene is located on the long arm of chromosome 17. This gene is a member of a phylogenetically conserved gene family and encodes the TBX2 T-box transcription factor protein, which is a regulator of the transcriptional activity of various genes, i.e. suppresses the expression of CDKN2A (p19ARF), inhibits cyclin-dependent kinase p21 Cip1 (CDKN1A), affects the expression of MYC, RAS, BRCA1 and BRCA2 genes. | ||
| کلیدواژه‌ها | ||
| Preeclampsia؛ Edema؛ Proteinuria؛ Polymorphic locus؛ rs1042838 PGR | ||
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آمار تعداد مشاهده مقاله: 13 |
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