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Jasim, O. H, Mahmood, M. M., Ad’hiah, A. H. (1400). Significance of Lipid Profile Parameters in Predicting Pre-Diabetes. سامانه مدیریت نشریات علمی, 77(1), 277-284. doi: 10.22092/ari.2021.356465.1846
O. H Jasim; M. M. Mahmood; A. H Ad’hiah. "Significance of Lipid Profile Parameters in Predicting Pre-Diabetes". سامانه مدیریت نشریات علمی, 77, 1, 1400, 277-284. doi: 10.22092/ari.2021.356465.1846
Jasim, O. H, Mahmood, M. M., Ad’hiah, A. H. (1400). 'Significance of Lipid Profile Parameters in Predicting Pre-Diabetes', سامانه مدیریت نشریات علمی, 77(1), pp. 277-284. doi: 10.22092/ari.2021.356465.1846
Jasim, O. H, Mahmood, M. M., Ad’hiah, A. H. Significance of Lipid Profile Parameters in Predicting Pre-Diabetes. سامانه مدیریت نشریات علمی, 1400; 77(1): 277-284. doi: 10.22092/ari.2021.356465.1846

Significance of Lipid Profile Parameters in Predicting Pre-Diabetes

Archives of Razi Institute
مقاله 37، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 277-284    اصل مقاله (616.52 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356465.1846
نویسندگان
O. H Jasim1؛ M. M. Mahmood* 1؛ A. H Ad’hiah2
1Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
2Tropical-Biological Research Unit, College of Science, University of Baghdad, Iraq
چکیده
In prediabetes, blood glucose levels are higher than normal; however, they remain below the diabetes threshold. Studies conducted on biomarkers for this disease result in controlling diabetes mellitus (DM) or reducing the risk of developing complications. Lipid profile parameters are considered important predictors of DM. Therefore, this study was conducted on three groups of normoglycemic (n=30), pre-diabetics (n=125), and diabetics (n=30) to recognize the predictive role of lipid parameters in the transition from pre-diabetes to diabetes. In this experiment, in addition to total cholesterol and triglycerides, very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride/HDL ratio, and fasting triglyceride-fasting blood glucose (FBG) index were measured. Based on the results, medians for total cholesterol, LDL, HDL, LDL/HDL ratio, cholesterol/HDL ratio, and LDL/HDL ratio did not differ significantly across the groups of normoglycemia, prediabetes, and diabetes. For triglyceride, the medians were significantly higher in pre-diabetes and also diabetes, compared to normoglycemia (i.e., 127.9 and 129.1 vs. 94.5 mg/dL, respectively [P<0.001]). Moreover, the same results were observed in the case of VLDL (i.e., 25.6 and 30.9 vs. 18.9 mg/dL, respectively). The triglyceride/HDL ratio significantly increased pre-diabetics and diabetics, compared to normoglycemic (2.72 and 2.67 vs. 2.18, respectively). Moreover, the median of the triglyceride-FBG index significantly had an increase in pre-diabetics and diabetics, compared to normoglycemic (8.89 and 9.38 vs. 8.22, respectively). The importance of triglyceride, VLDL, triglyceride/HDL ratio, and triglyceride-FBG index in distinguishing between pre-diabetes and normoglycemia was verified by a receiver operating characteristic curve analysis of the results. Logistic regression analysis confirmed the risk effects of the four parameters on pre-diabetes and diabetes. Therefore, triglyceride, VLDL, triglyceride-FBG index, and triglyceride/HDL ratio are considered promising biomarkers used to predict pre-diabetes and DM in the general population.
کلیدواژه‌ها
Pre-diabetes؛ Diabetes؛ Normoglycemia؛ Lipid profile؛ Triglyceride-glucose index؛ Triglyceride/high-density lipoprotein ratio
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مراجع
  1. Abusaib M, Ahmed M, Nwayyir HA, Alidrisi HA, Al-Abbood M, Al-Bayati A, et al. Iraqi Experts Consensus on the Management of Type 2 Diabetes/Prediabetes in Adults. Clin Med Insights Endocrinol Diabetes. 2020;13:1179551420942232.
  2. Onyango EM, Onyango BM. The Rise of Noncommunicable Diseases in Kenya: An Examination of the Time Trends and Contribution of the Changes in Diet and Physical Inactivity. J Epidemiol Glob Health. 2018;8(1-2):1-7.
  3. Cui J, Liu Y, Li Y, Xu F, Liu Y. Type 2 Diabetes and Myocardial Infarction: Recent Clinical Evidence and Perspective. Front Cardiovasc Med. 2021;8:644189.
  4. Sarría-Santamera A, Orazumbekova B, Maulenkul T, Salustri A, Glushkova N, Makashev D, et al. Macrovascular Complications in Patients with Diabetes Mellitus: Incidence and Impact on Survival in Kazakhstan. Res Sq. 2021.
  5. Hirano T. Pathophysiology of Diabetic Dyslipidemia. J Atheroscler Thromb. 2018;25(9):771-82.
  6. Wu L, Parhofer KG. Diabetic dyslipidemia. Metab Clin Exp. 2014;63(12):1469-79.
  7. Bhowmik B, Siddiquee T, Mujumder A, Afsana F, Ahmed T, Mdala IA, et al. Serum Lipid Profile and Its Association with Diabetes and Prediabetes in a Rural Bangladeshi Population. Int J Environ Res Public Health. 2018;15(9).
  8. Rijkelijkhuizen JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD, Dekker JM. High risk of cardiovascular mortality in individuals with impaired fasting glucose is explained by conversion to diabetes: the Hoorn study. Diabetes Care. 2007;30(2):332-6.
  9. Mooradian AD. Dyslipidemia in type 2 diabetes mellitus. Nat Clin Pract Endocrinol Metab. 2009;5(3):150-9.
  10. Santos-Gallego CG, Rosenson RS. Role of HDL in those with diabetes. Curr Cardiol Rep. 2014;16(8):512.
  11. Wang L, Cong HL, Zhang JX, Hu YC, Wei A, Zhang YY, et al. Triglyceride-glucose index predicts adverse cardiovascular events in patients with diabetes and acute coronary syndrome. Cardiovasc Diabetol. 2020;19(1):80.
  12. Association AD. Standards of Medical Care in Diabetes-2016: Summary of Revisions. Diabetes Care. 2016;39 (1):S4-5.
  13. Guerrero-Romero F, Simental-Mendia LE, Gonzalez-Ortiz M, Martinez-Abundis E, Ramos-Zavala MG, Hernandez-Gonzalez SO, et al. The product of triglycerides and glucose, a simple measure of insulin sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp. J Clin Endocrinol Metab. 2010;95(7):3347-51.
  14. Alexopoulos AS, Qamar A, Hutchins K, Crowley MJ, Batch BC, Guyton JR. Triglycerides: Emerging Targets in Diabetes Care? Review of Moderate Hypertriglyceridemia in Diabetes. Curr Diab Rep. 2019;19(4):13.
  15. Nichols GA, Philip S, Reynolds K, Granowitz CB, Fazio S. Increased Cardiovascular Risk in Hypertriglyceridemic Patients With Statin-Controlled LDL Cholesterol. J Clin Endocrinol Metab. 2018;103(8):3019-27.
  16. Upadhyay RK. Emerging risk biomarkers in cardiovascular diseases and disorders. J Lipids. 2015;2015:971453.
  17. Aarsland A, Chinkes D, Wolfe RR. Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man. J Clin Invest. 1996;98(9):2008-17.
  18. McLaughlin T, Abbasi F, Lamendola C, Yeni-Komshian H, Reaven G. Carbohydrate-induced hypertriglyceridemia: an insight into the link between plasma insulin and triglyceride concentrations. J Clin Endocrinol Metab. 2000;85(9):3085-8.
  19. Cheal KL, Abbasi F, Lamendola C, McLaughlin T, Reaven GM, Ford ES. Relationship to insulin resistance of the adult treatment panel III diagnostic criteria for identification of the metabolic syndrome. Diabetes. 2004;53(5):1195-200.
  20. Lee SJ, Moye LA, Campos H, Williams GH, Sacks FM. Hypertriglyceridemia but not diabetes status is associated with VLDL containing apolipoprotein CIII in patients with coronary heart disease. Atherosclerosis. 2003;167(2):293-302.
  21. Tirosh A, Shai I, Bitzur R, Kochba I, Tekes-Manova D, Israeli E, et al. Changes in triglyceride levels over time and risk of type 2 diabetes in young men. Diabetes Care. 2008;31(10):2032-7.
  22. Emerging Risk Factors C, Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302(18):1993-2000.
  23. Lim J, Kim J, Koo SH, Kwon GC. Comparison of triglyceride glucose index, and related parameters to predict insulin resistance in Korean adults: An analysis of the 2007-2010 Korean National Health and Nutrition Examination Survey. PLoS One. 2019;14(3):0212963.
  24. Cerf ME. Beta cell dysfunction and insulin resistance. Front Endocrinol (Lausanne). 2013;4:37.
  25. Gast KB, Tjeerdema N, Stijnen T, Smit JW, Dekkers OM. Insulin resistance and risk of incident cardiovascular events in adults without diabetes: meta-analysis. PLoS One. 2012;7(12):e52036.
  1. Xia C, Li R, Zhang S, Gong L, Ren W, Wang Z, et al. Lipid accumulation product is a powerful index for recognizing insulin resistance in non-diabetic individuals. Eur J Clin Nutr. 2012;66(9):1035-8.
  2. Tuso P. Prediabetes and lifestyle modification: time to prevent a preventable disease. Perm J. 2014;18(3):88-93.
  3. Reaven G. The metabolic syndrome or the insulin resistance syndrome? Different names, different concepts, and different goals. Endocrinol Metab Clin North Am. 2004;33(2):283-303.
  4. Pihlajamaki J, Gylling H, Miettinen TA, Laakso M. Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men. J Lipid Res. 2004;45(3):507-12.
  5. Kansal S, Kamble TK. Lipid Profile in Prediabetes. J Assoc Physicians India. 2016;64(3):18-21.
  6. Dobiás̆ová M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate inapob-lipoprotein-depleted plasma (FERHDL). Clin Biochem. 2001;34(7):583-8.
  7. González-Chávez A, Simental-Mendía LE, Elizondo-Argueta S. Elevated triglycerides/HDL-cholesterol ratio associated with insulin resistance. Cir Cir. 2011;79(2):126-31.
  8. Keles N, Aksu F, Aciksari G, Yilmaz Y, Demircioglu K, Kostek O, et al. Is triglyceride/HDL ratio a reliable screening test for assessment of atherosclerotic risk in patients with chronic inflammatory disease? North Clin Istanb. 2016;3(1):39-45.
  9. Babic N, Valjevac A, Zaciragic A, Avdagic N, Zukic S, Hasic S. The Triglyceride/HDL Ratio and Triglyceride Glucose Index as Predictors of Glycemic Control in Patients with Diabetes Mellitus Type 2. Med Arch. 2019;73(3):163-8.
35.          Chen Z, Hu H, Chen M, Luo X, Yao W, Liang Q, et al. Association of Triglyceride to high-density lipoprotein cholesterol ratio and incident of diabetes mellitus: a secondary retrospective analysis based on a Chinese cohort study. Lipids Health Dis. 2020;19(1):33.

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