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Ali Abdulla, A, Abdulaali Abed, T, Razzaq Abdul-Ameer, W. (1400). Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis. سامانه مدیریت نشریات علمی, 77(1), 81-86. doi: 10.22092/ari.2021.356470.1848
A Ali Abdulla; T Abdulaali Abed; W Razzaq Abdul-Ameer. "Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis". سامانه مدیریت نشریات علمی, 77, 1, 1400, 81-86. doi: 10.22092/ari.2021.356470.1848
Ali Abdulla, A, Abdulaali Abed, T, Razzaq Abdul-Ameer, W. (1400). 'Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis', سامانه مدیریت نشریات علمی, 77(1), pp. 81-86. doi: 10.22092/ari.2021.356470.1848
Ali Abdulla, A, Abdulaali Abed, T, Razzaq Abdul-Ameer, W. Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis. سامانه مدیریت نشریات علمی, 1400; 77(1): 81-86. doi: 10.22092/ari.2021.356470.1848

Impact of IL-21 Gene Polymorphisms (rs2055979) and the Levels of Serum IL-21 on the Risk of Multiple Sclerosis

Archives of Razi Institute
مقاله 12، دوره 77، شماره 1، فروردین و اردیبهشت 2022، صفحه 81-86    اصل مقاله (364.5 K)
نوع مقاله: Original Articles
شناسه دیجیتال (DOI): 10.22092/ari.2021.356470.1848
نویسندگان
A Ali Abdulla* 1؛ T Abdulaali Abed1؛ W Razzaq Abdul-Ameer2
1Department of Biology, College of Sciences, University of Babylon, Babylon, Iraq
2Department of Medicine, Neurology, College of Medicine, University of Babylon, Babylon, Iraq
چکیده
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system. Genetic and environmental factors have important roles in the induction, onset, and progression of MS. In this study, the IL-21 genotype (rs2055979) (G/T) in Iraqi MS patients was compared with a healthy control group to investigate the possible association of any particular genotype or allele with multiple sclerosis. This study included 70 patients with relapsing-remitting MS and 50 healthy individuals as control. Following the extraction of genomic DNA, polymerase chain reaction-restriction fragment length polymorphism, the frequencies of genotypes, and alleles were calculated and statistically analyzed. The results of the study revealed a significant reduction in the distribution of the wild homozygous genotype (GG) in MS patients, in comparison to a healthy control group (14.3% vs. 34 %; 0.0129 at P≤0.05; odds ratio [OR] 3.0909, 95% confidence interval [CI]: 1.2704-7.5203). However, MS cases and controls did not differ significantly in neither GT nor TT genotypes, 62.9% (OR 0.6402, 95% CI: 0.3064-1.3374) and 52% (OR 0.5494, 95% CI: 0.2074-1.4557), respectively. The data of allele frequencies in patients and controls showed that the G allele frequencies were 0.46 vs. 0.60 in patients and controls, respectively, while T allele frequencies were 0.54 vs. 0.40 in patients and controls, respectively. The current conclusions indicated that in the study group, the GG genotype of IL-21(rs2055979) could be related to MS.
کلیدواژه‌ها
IL-21؛ rs2055979؛ Multiple sclerosis؛ PCR-RFLP
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مراجع
  1. Dyment DA, Sadnovich AD, Ebers GC. Genetics of multiple sclerosis. Hum Mol Genet. 1997;6(10):1693-8.
  2. O’Gorman C, Lucas R, Taylor B. Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms. Int J Mol Sci. 2012;13(9):11718-52.
  3. Spolski R, Leonard WJ. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol. 2008;26:57-79.
  4. Shekhar S, Yang X. The darker side of follicular helper T cells: from autoimmunity to immunodeficiency. Cell Mol Immunol. 2012;9(5):380-5.
  5. Vollmer TL, Liu R, Price M, Rhodes S, La Cava A, Shi F-D. Differential effects of IL-21 during initiation and progression of autoimmunity against neuroantigen. J Immunol. 2005;174(5):2696-701.
  6. Suto A, Kashiwakuma D, Kagami S-i, Hirose K, Watanabe N, Yokote K, et al. Development and characterization of IL-21–producing CD4+ T cells. J Exp Med. 2008;205(6):1369-79.
  7. Olsson T. Cytokine-producing cells in experimental autoimmune encephalomyelitis and multiple sclerosis. Neurology. 1995;45(6):11-5.
 

  1. Diaz-Gallo L-M, Simeon CP, Broen JC, Ortego-Centeno N, Beretta L, Vonk MC, et al. Implication of IL-2/IL-21 region in systemic sclerosis genetic susceptibility. Annals of the rheumatic diseases. 2013;72(7):1233-8.
  2. Zhernakova A, Alizadeh BZ, Bevova M, van Leeuwen MA, Coenen MJ, Franke B, et al. Novel association in chromosome 4q27 region with rheumatoid arthritis and confirmation of type 1 diabetes point to a general risk locus for autoimmune diseases. Am J Hum Genet. 2007;81(6):1284-8.
  3. de Wit J, Jorritsma T, Makuch M, Remmerswaal EB, Bos HK, Souwer Y, et al. Human B cells promote T-cell plasticity to optimize antibody response by inducing coexpression of TH1/TFH signatures. J Allergy Clin Immunol. 2015;135(4):1053-60.
  4. Milo R, Miller A. Revised diagnostic criteria of multiple sclerosis. Autoimmun Rev. 2014;13(4-5):518-24.
  5. Gharibi T, Kazemi T, Aliparasti MR, Farhoudi M, Almasi S, Dehghanzadeh R. Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran. Am J Clin Exp Immunol. 2015;4(1):7.
  6. Sambrook J, Russell D. Molecular cloning: A laboratory manual. Mol. Cloning A Lab Man. 2001.
  7. Cary N. Statistical analysis system, User's guide. Statistical. Version 9. SAS Inst Inc USA. 2012.
  8. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983;33(11):1444-.
  9. Gharibi T, Hosseini A, Marofi F, Oraei M, Jahandideh S, Abdollahpour-Alitappeh M, et al. IL-21 and IL-21-producing T cells are involved in multiple sclerosis severity and progression. Immunol Lett. 2019;216:12-20.
  1. Jones JL, Phuah C-L, Cox AL, Thompson SA, Ban M, Shawcross J, et al. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest. 2009;119(7):2052-61.
  2. Zhang X, Tao Y, Chopra M, Ahn M, Marcus KL, Choudhary N, et al. Differential reconstitution of T cell subsets following immunodepleting treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with relapsing–remitting multiple sclerosis. J Immunol. 2013;191(12):5867-74.
  3. Ghalamfarsa G, Mahmoudi M, Mohammadnia-Afrouzi M, Yazdani Y, Anvari E, Hadinia A, et al. IL-21 and IL-21 receptor in the immunopathogenesis of multiple sclerosis. J Immunotoxicol. 2016;13(3):274-85.
  4. Tzartos JS, Craner MJ, Friese MA, Jakobsen KB, Newcombe J, Esiri MM, et al. IL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain. Am J Pathol. 2011;178(2):794-802.
  5. Akesson E, Oturai A, Berg J, Fredrikson S, Andersen O, Harbo H, et al. A genome-wide screen for linkage in Nordic sib-pairs with multiple sclerosis. Genes Immun. 2002;3(5):279-85.
  6. Davis ID, Skak K, Smyth MJ, Kristjansen PE, Miller DM, Sivakumar PV. Interleukin-21 signaling: functions in cancer and autoimmunity. Clin Cancer Res. 2007;13(23):6926-32.
  7. McAlpine D, Compston A. McAlpine's multiple sclerosis: Elsevier Health Sciences; 2005.
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